BRD-K74486276_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

94 genes differentially expressed following the BRD-K74486276_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRE5 adhesion G protein-coupled receptor E5
ADGRF5 adhesion G protein-coupled receptor F5
ADGRG6 adhesion G protein-coupled receptor G6
ADIRF adipogenesis regulatory factor
AKR1C3 aldo-keto reductase family 1, member C3
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANXA1 annexin A1
ANXA4 annexin A4
APOD apolipoprotein D
AQP1 aquaporin 1 (Colton blood group)
ARHGAP29 Rho GTPase activating protein 29
BTG1 B-cell translocation gene 1, anti-proliferative
C3ORF14 chromosome 3 open reading frame 14
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCNG2 cyclin G2
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CKLF chemokine-like factor
CRABP1 cellular retinoic acid binding protein 1
CRABP2 cellular retinoic acid binding protein 2
CSRP1 cysteine and glycine-rich protein 1
CTGF connective tissue growth factor
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DPYSL2 dihydropyrimidinase-like 2
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
FABP4 fatty acid binding protein 4, adipocyte
FAM63A family with sequence similarity 63, member A
FZD6 frizzled class receptor 6
GPRC5A G protein-coupled receptor, class C, group 5, member A
HIST1H1C histone cluster 1, H1c
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IL1B interleukin 1, beta
INHBB inhibin, beta B
ISG15 ISG15 ubiquitin-like modifier
KRT7 keratin 7, type II
LGALS1 lectin, galactoside-binding, soluble, 1
LMCD1 LIM and cysteine-rich domains 1
LMO3 LIM domain only 3 (rhombotin-like 2)
MCAM melanoma cell adhesion molecule
METRN meteorin, glial cell differentiation regulator
MGP matrix Gla protein
MLPH melanophilin
MX1 MX dynamin-like GTPase 1
MYO1B myosin IB
NLGN4X neuroligin 4, X-linked
PLIN2 perilipin 2
PLS1 plastin 1
PNMA2 paraneoplastic Ma antigen 2
PRSS3 protease, serine, 3
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
RCAN1 regulator of calcineurin 1
RHOB ras homolog family member B
S100A4 S100 calcium binding protein A4
SCGB2A2 secretoglobin, family 2A, member 2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SMAD3 SMAD family member 3
SNCA synuclein, alpha (non A4 component of amyloid precursor)
TCTA T-cell leukemia translocation altered
TFRC transferrin receptor
TMBIM1 transmembrane BAX inhibitor motif containing 1
TPD52L1 tumor protein D52-like 1
TSC22D1 TSC22 domain family, member 1
TUBB2B tubulin, beta 2B class IIb
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
AKAP8 A kinase (PRKA) anchor protein 8
C1S complement component 1, s subcomponent
CLU clusterin
CRTC3 CREB regulated transcription coactivator 3
DLK1 delta-like 1 homolog (Drosophila)
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
EGFR epidermal growth factor receptor
FBN2 fibrillin 2
FLRT2 fibronectin leucine rich transmembrane protein 2
HMG20B high mobility group 20B
KCTD5 potassium channel tetramerization domain containing 5
KLHL21 kelch-like family member 21
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MCL1 myeloid cell leukemia 1
PLTP phospholipid transfer protein
RGS1 regulator of G-protein signaling 1
SET SET nuclear proto-oncogene
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC52A2 solute carrier family 52 (riboflavin transporter), member 2
SPON1 spondin 1, extracellular matrix protein
Funding