BRD-K74486276_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

68 genes differentially expressed following the BRD-K74486276_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
BLNK B-cell linker
C3ORF14 chromosome 3 open reading frame 14
CCL4 chemokine (C-C motif) ligand 4
CD38 CD38 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CLDN3 claudin 3
CLTC clathrin, heavy chain (Hc)
DST dystonin
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FBN2 fibrillin 2
G0S2 G0/G1 switch 2
GLRX glutaredoxin (thioltransferase)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
IDO1 indoleamine 2,3-dioxygenase 1
IGLL1 immunoglobulin lambda-like polypeptide 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KANK1 KN motif and ankyrin repeat domains 1
KDM5D lysine (K)-specific demethylase 5D
KRT81 keratin 81, type II
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MME membrane metallo-endopeptidase
NEFH neurofilament, heavy polypeptide
NEFL neurofilament, light polypeptide
NTS neurotensin
OLFM1 olfactomedin 1
OLFM4 olfactomedin 4
OLFML2A olfactomedin-like 2A
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PLAU plasminogen activator, urokinase
PLXNC1 plexin C1
QPCT glutaminyl-peptide cyclotransferase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
REG1B regenerating islet-derived 1 beta
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SFN stratifin
SOX9 SRY (sex determining region Y)-box 9
SYT1 synaptotagmin I
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFF3 trefoil factor 3 (intestinal)
TPD52 tumor protein D52
TRIM2 tripartite motif containing 2
VLDLR very low density lipoprotein receptor
WARS tryptophanyl-tRNA synthetase
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
BPIFA1 BPI fold containing family A, member 1
CLEC11A C-type lectin domain family 11, member A
CRIP1 cysteine-rich protein 1 (intestinal)
DHRS2 dehydrogenase/reductase (SDR family) member 2
ELANE elastase, neutrophil expressed
ERBB4 erb-b2 receptor tyrosine kinase 4
FST follistatin
GAL galanin/GMAP prepropeptide
GTPBP8 GTP-binding protein 8 (putative)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAOB monoamine oxidase B
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MSLN mesothelin
PTGDS prostaglandin D2 synthase 21kDa (brain)
PWP1 PWP1 homolog (S. cerevisiae)
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
Funding