BRD-K74710236_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

116 genes differentially expressed following the BRD-K74710236_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ALDOC aldolase C, fructose-bisphosphate
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG2 BTG family, member 2
CCNG2 cyclin G2
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CKB creatine kinase, brain
COL11A1 collagen, type XI, alpha 1
DDIT4 DNA-damage-inducible transcript 4
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL2 dihydropyrimidinase-like 2
EGLN3 egl-9 family hypoxia-inducible factor 3
ENO1 enolase 1, (alpha)
ENO2 enolase 2 (gamma, neuronal)
FAM162A family with sequence similarity 162, member A
FAS Fas cell surface death receptor
FLG filaggrin
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL1 FOS-like antigen 1
FSD1 fibronectin type III and SPRY domain containing 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GBE1 glucan (1,4-alpha-), branching enzyme 1
GLUL glutamate-ammonia ligase
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
ISG20 interferon stimulated exonuclease gene 20kDa
KDM3A lysine (K)-specific demethylase 3A
KDM4B lysine (K)-specific demethylase 4B
KLF10 Kruppel-like factor 10
LGALS8 lectin, galactoside-binding, soluble, 8
LY96 lymphocyte antigen 96
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MT1X metallothionein 1X
MXI1 MAX interactor 1, dimerization protein
NARF nuclear prelamin A recognition factor
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NREP neuronal regeneration related protein
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNMA2 paraneoplastic Ma antigen 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRUNE2 prune homolog 2 (Drosophila)
QPCT glutaminyl-peptide cyclotransferase
RAB38 RAB38, member RAS oncogene family
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RIOK3 RIO kinase 3
SGK1 serum/glucocorticoid regulated kinase 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPAG4 sperm associated antigen 4
STC1 stanniocalcin 1
TMEM45A transmembrane protein 45A
TNIP1 TNFAIP3 interacting protein 1
TOX3 TOX high mobility group box family member 3
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
YPEL5 yippee-like 5 (Drosophila)
ZNF12 zinc finger protein 12

decreased expression

Symbol Name
AQP3 aquaporin 3 (Gill blood group)
ARFIP2 ADP-ribosylation factor interacting protein 2
ATF5 activating transcription factor 5
AURKA aurora kinase A
CCNA2 cyclin A2
CCNF cyclin F
CDC25B cell division cycle 25B
CDCA3 cell division cycle associated 3
CENPA centromere protein A
COL3A1 collagen, type III, alpha 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DEPDC1 DEP domain containing 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GATA3 GATA binding protein 3
GTSE1 G-2 and S-phase expressed 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1A heat shock 70kDa protein 1A
HSPD1 heat shock 60kDa protein 1 (chaperonin)
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KRT7 keratin 7, type II
LTF lactotransferrin
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM10 minichromosome maintenance complex component 10
MRPS12 mitochondrial ribosomal protein S12
PLK1 polo-like kinase 1
PODXL podocalyxin-like
POSTN periostin, osteoblast specific factor
PRMT1 protein arginine methyltransferase 1
TACSTD2 tumor-associated calcium signal transducer 2
TARP TCR gamma alternate reading frame protein
TGFB1 transforming growth factor, beta 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
UBE2C ubiquitin-conjugating enzyme E2C
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1