BRD-K74761218_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

338 genes differentially expressed following the BRD-K74761218_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABAT 4-aminobutyrate aminotransferase
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ACAA1 acetyl-CoA acyltransferase 1
ACOT7 acyl-CoA thioesterase 7
ADRB2 adrenoceptor beta 2, surface
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTPBP1 ATP/GTP binding protein 1
AKTIP AKT interacting protein
ALAS1 5'-aminolevulinate synthase 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDOB aldolase B, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANKRD46 ankyrin repeat domain 46
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
APAF1 apoptotic peptidase activating factor 1
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARMCX3 armadillo repeat containing, X-linked 3
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ATG2A autophagy related 2A
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BCL3 B-cell CLL/lymphoma 3
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C14ORF132 chromosome 14 open reading frame 132
C2CD2L C2CD2-like
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALU calumenin
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CCND3 cyclin D3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CLDND1 claudin domain containing 1
CLIC4 chloride intracellular channel 4
CLPTM1 cleft lip and palate associated transmembrane protein 1
CLU clusterin
CMC2 C-x(9)-C motif containing 2
COG5 component of oligomeric golgi complex 5
COMP cartilage oligomeric matrix protein
CORO1A coronin, actin binding protein, 1A
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSRP1 cysteine and glycine-rich protein 1
CTSA cathepsin A
CYB5R1 cytochrome b5 reductase 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYLD cylindromatosis (turban tumor syndrome)
DAAM1 dishevelled associated activator of morphogenesis 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DCTN3 dynactin 3 (p22)
DGKA diacylglycerol kinase, alpha 80kDa
DHCR7 7-dehydrocholesterol reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DSTN destrin (actin depolymerizing factor)
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFNB2 ephrin-B2
EPHB2 EPH receptor B2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EZR ezrin
FABP1 fatty acid binding protein 1, liver
FADS3 fatty acid desaturase 3
FAM102A family with sequence similarity 102, member A
FBLN5 fibulin 5
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FOXF1 forkhead box F1
FOXO4 forkhead box O4
FYB FYN binding protein
G0S2 G0/G1 switch 2
GCA grancalcin, EF-hand calcium binding protein
GLRX glutaredoxin (thioltransferase)
GM2A GM2 ganglioside activator
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GSN gelsolin
HEBP1 heme binding protein 1
HECA headcase homolog (Drosophila)
HN1 hematological and neurological expressed 1
HSPA1A heat shock 70kDa protein 1A
IDI1 isopentenyl-diphosphate delta isomerase 1
IDS iduronate 2-sulfatase
IFI6 interferon, alpha-inducible protein 6
IGFBP5 insulin-like growth factor binding protein 5
IL32 interleukin 32
ISG15 ISG15 ubiquitin-like modifier
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCNK3 potassium channel, two pore domain subfamily K, member 3
KCTD5 potassium channel tetramerization domain containing 5
KIF5C kinesin family member 5C
LBH limb bud and heart development
LIMA1 LIM domain and actin binding 1
LIPA lipase A, lysosomal acid, cholesterol esterase
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
LRRN3 leucine rich repeat neuronal 3
LTA4H leukotriene A4 hydrolase
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAST3 microtubule associated serine/threonine kinase 3
MCOLN1 mucolipin 1
MGP matrix Gla protein
MGST3 microsomal glutathione S-transferase 3
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MLEC malectin
MPC1 mitochondrial pyruvate carrier 1
MSMO1 methylsterol monooxygenase 1
MSRB1 methionine sulfoxide reductase B1
MT1X metallothionein 1X
MVP major vault protein
NAGK N-acetylglucosamine kinase
NDRG1 N-myc downstream regulated 1
NFIL3 nuclear factor, interleukin 3 regulated
NME7 NME/NM23 family member 7
NMT2 N-myristoyltransferase 2
NOSIP nitric oxide synthase interacting protein
NPC1 Niemann-Pick disease, type C1
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
OLFM4 olfactomedin 4
OPN3 opsin 3
OSTF1 osteoclast stimulating factor 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PALLD palladin, cytoskeletal associated protein
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PDPK1 3-phosphoinositide dependent protein kinase 1
PEG10 paternally expressed 10
PEX3 peroxisomal biogenesis factor 3
PHKG2 phosphorylase kinase, gamma 2 (testis)
PLA2G15 phospholipase A2, group XV
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLXNA3 plexin A3
POLR2J polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa
POR P450 (cytochrome) oxidoreductase
PRDM2 PR domain containing 2, with ZNF domain
PRKCD protein kinase C, delta
PRSS2 protease, serine, 2 (trypsin 2)
PRSS3 protease, serine, 3
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPRD protein tyrosine phosphatase, receptor type, D
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RABAC1 Rab acceptor 1 (prenylated)
RAD9A RAD9 homolog A (S. pombe)
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RBP1 retinol binding protein 1, cellular
RGS13 regulator of G-protein signaling 13
RHOB ras homolog family member B
RIMS3 regulating synaptic membrane exocytosis 3
RND1 Rho family GTPase 1
S100A11 S100 calcium binding protein A11
SC5D sterol-C5-desaturase
SCRG1 stimulator of chondrogenesis 1
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SEPT6 septin 6
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SH3GLB2 SH3-domain GRB2-like endophilin B2
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC46A3 solute carrier family 46, member 3
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SLC9A6 solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6
SPTAN1 spectrin, alpha, non-erythrocytic 1
SRPK2 SRSF protein kinase 2
SST somatostatin
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STAB1 stabilin 1
STK17A serine/threonine kinase 17a
STX12 syntaxin 12
STX1A syntaxin 1A (brain)
STX7 syntaxin 7
SYNDIG1 synapse differentiation inducing 1
TCL1A T-cell leukemia/lymphoma 1A
TIMP3 TIMP metallopeptidase inhibitor 3
TKT transketolase
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPST2 tyrosylprotein sulfotransferase 2
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
TUBA4A tubulin, alpha 4a
TUFT1 tuftelin 1
TYROBP TYRO protein tyrosine kinase binding protein
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAT1 vesicle amine transport 1
VCL vinculin
VNN1 vanin 1
VWA5A von Willebrand factor A domain containing 5A
WDR47 WD repeat domain 47
WFS1 Wolfram syndrome 1 (wolframin)
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKAP8 A kinase (PRKA) anchor protein 8
ALCAM activated leukocyte cell adhesion molecule
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
APOL3 apolipoprotein L, 3
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ATF1 activating transcription factor 1
ATF5 activating transcription factor 5
AURKA aurora kinase A
BCLAF1 BCL2-associated transcription factor 1
BEX1 brain expressed, X-linked 1
CBR3 carbonyl reductase 3
CCND1 cyclin D1
CD58 CD58 molecule
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CXCL3 chemokine (C-X-C motif) ligand 3
CYFIP1 cytoplasmic FMR1 interacting protein 1
DCLK1 doublecortin-like kinase 1
DCTD dCMP deaminase
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DEAF1 DEAF1 transcription factor
DEK DEK proto-oncogene
DFNA5 deafness, autosomal dominant 5
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPYD dihydropyrimidine dehydrogenase
DRAM1 DNA-damage regulated autophagy modulator 1
DUSP4 dual specificity phosphatase 4
DUT deoxyuridine triphosphatase
ELOVL6 ELOVL fatty acid elongase 6
EMG1 EMG1 N1-specific pseudouridine methyltransferase
EMP3 epithelial membrane protein 3
EXOSC4 exosome component 4
FAM57A family with sequence similarity 57, member A
FAM60A family with sequence similarity 60, member A
FBN1 fibrillin 1
FEN1 flap structure-specific endonuclease 1
FOSL1 FOS-like antigen 1
FOXM1 forkhead box M1
GABPB1 GA binding protein transcription factor, beta subunit 1
GLUL glutamate-ammonia ligase
GMPR guanosine monophosphate reductase
GRWD1 glutamate-rich WD repeat containing 1
GSAP gamma-secretase activating protein
GSTO1 glutathione S-transferase omega 1
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HDGFRP3 hepatoma-derived growth factor, related protein 3
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIST1H2BG histone cluster 1, H2bg
HMGA2 high mobility group AT-hook 2
HNMT histamine N-methyltransferase
HOXA10 homeobox A10
HOXA5 homeobox A5
HOXB2 homeobox B2
HOXB7 homeobox B7
HOXC6 homeobox C6
IDO1 indoleamine 2,3-dioxygenase 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IRAK1 interleukin-1 receptor-associated kinase 1
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
KEAP1 kelch-like ECH-associated protein 1
KHNYN KH and NYN domain containing
KIF18B kinesin family member 18B
KLF9 Kruppel-like factor 9
KRT5 keratin 5, type II
KYNU kynureninase
LAMC1 laminin, gamma 1 (formerly LAMB2)
LCMT2 leucine carboxyl methyltransferase 2
LRRC41 leucine rich repeat containing 41
LY6E lymphocyte antigen 6 complex, locus E
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAPK6 mitogen-activated protein kinase 6
MCTP1 multiple C2 domains, transmembrane 1
MDK midkine (neurite growth-promoting factor 2)
MECOM MDS1 and EVI1 complex locus
MOK MOK protein kinase
MSLN mesothelin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NID1 nidogen 1
NMI N-myc (and STAT) interactor
NREP neuronal regeneration related protein
NRIP1 nuclear receptor interacting protein 1
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUP50 nucleoporin 50kDa
OBSL1 obscurin-like 1
OTUD4 OTU deubiquitinase 4
PAN2 PAN2 poly(A) specific ribonuclease subunit
PARVB parvin, beta
PAXIP1 PAX interacting (with transcription-activation domain) protein 1
PDE4A phosphodiesterase 4A, cAMP-specific
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIR pirin (iron-binding nuclear protein)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PON2 paraoxonase 2
PRC1 protein regulator of cytokinesis 1
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RAB13 RAB13, member RAS oncogene family
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RRM2 ribonucleotide reductase M2
RTP4 receptor (chemosensory) transporter protein 4
SCGB2A1 secretoglobin, family 2A, member 1
SENP6 SUMO1/sentrin specific peptidase 6
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SNRPE small nuclear ribonucleoprotein polypeptide E
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SPRY2 sprouty homolog 2 (Drosophila)
SRSF5 serine/arginine-rich splicing factor 5
SUMO3 small ubiquitin-like modifier 3
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TCERG1 transcription elongation regulator 1
THBS1 thrombospondin 1
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TLR4 toll-like receptor 4
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TSPAN8 tetraspanin 8
TWIST1 twist family bHLH transcription factor 1
TYMS thymidylate synthetase
UBE2E3 ubiquitin-conjugating enzyme E2E 3
USP22 ubiquitin specific peptidase 22
VCAN versican
ZBED1 zinc finger, BED-type containing 1
ZC3H4 zinc finger CCCH-type containing 4
ZMYND11 zinc finger, MYND-type containing 11
ZNF512B zinc finger protein 512B