BRD-K75302809_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

102 genes differentially expressed following the BRD-K75302809_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADI1 acireductone dioxygenase 1
ANXA3 annexin A3
APOD apolipoprotein D
AREG amphiregulin
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
C6ORF62 chromosome 6 open reading frame 62
CAPRIN2 caprin family member 2
CCDC47 coiled-coil domain containing 47
CCNB2 cyclin B2
CD59 CD59 molecule, complement regulatory protein
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHMP4A charged multivesicular body protein 4A
CRYZ crystallin, zeta (quinone reductase)
DCK deoxycytidine kinase
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DEGS1 delta(4)-desaturase, sphingolipid 1
DLD dihydrolipoamide dehydrogenase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DST dystonin
EBNA1BP2 EBNA1 binding protein 2
EGFR epidermal growth factor receptor
G0S2 G0/G1 switch 2
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
GTPBP8 GTP-binding protein 8 (putative)
HOXA10 homeobox A10
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPB11 heat shock protein family B (small), member 11
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1
ITGB5 integrin, beta 5
KIF2C kinesin family member 2C
KRT14 keratin 14, type I
KRT15 keratin 15, type I
LCN2 lipocalin 2
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LXN latexin
LYPLA1 lysophospholipase I
MAN1A1 mannosidase, alpha, class 1A, member 1
MARCKSL1 MARCKS-like 1
MGLL monoglyceride lipase
MPZL1 myelin protein zero-like 1
NAMPT nicotinamide phosphoribosyltransferase
NANS N-acetylneuraminic acid synthase
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
OLFM4 olfactomedin 4
OSBPL8 oxysterol binding protein-like 8
PPAT phosphoribosyl pyrophosphate amidotransferase
PRPF4 pre-mRNA processing factor 4
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTN pleiotrophin
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RAB40B RAB40B, member RAS oncogene family
RECQL RecQ helicase-like
RHOBTB3 Rho-related BTB domain containing 3
RNF6 ring finger protein (C3H2C3 type) 6
RPS11 ribosomal protein S11
S100A13 S100 calcium binding protein A13
SFN stratifin
SMS spermine synthase
SRPK2 SRSF protein kinase 2
SSR1 signal sequence receptor, alpha
TM4SF1 transmembrane 4 L six family member 1
TMEM165 transmembrane protein 165
TOP2A topoisomerase (DNA) II alpha 170kDa
TPR translocated promoter region, nuclear basket protein
TSNAX translin-associated factor X
TVP23B trans-golgi network vesicle protein 23 homolog B (S. cerevisiae)
UFM1 ubiquitin-fold modifier 1
USP1 ubiquitin specific peptidase 1
USP22 ubiquitin specific peptidase 22
XBP1 X-box binding protein 1

decreased expression

Symbol Name
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
BCHE butyrylcholinesterase
CA2 carbonic anhydrase II
CA9 carbonic anhydrase IX
CALR calreticulin
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CLDN18 claudin 18
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSE cathepsin E
ELANE elastase, neutrophil expressed
F2RL1 coagulation factor II (thrombin) receptor-like 1
GAL galanin/GMAP prepropeptide
GRB7 growth factor receptor-bound protein 7
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
LDOC1 leucine zipper, down-regulated in cancer 1
MAN2A1 mannosidase, alpha, class 2A, member 1
NID1 nidogen 1
PGC progastricsin (pepsinogen C)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SPON1 spondin 1, extracellular matrix protein
SRC SRC proto-oncogene, non-receptor tyrosine kinase
WNT5A wingless-type MMTV integration site family, member 5A
XIST X inactive specific transcript (non-protein coding)
Funding