BRD-K75532464_FTI-276 Trifluoroacetate_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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59 genes differentially expressed following the BRD-K75532464_FTI-276 Trifluoroacetate_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
BEX4 brain expressed, X-linked 4
CPE carboxypeptidase E
DSC2 desmocollin 2
FAM69A family with sequence similarity 69, member A
FRZB frizzled-related protein
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H2BG histone cluster 1, H2bg
IL32 interleukin 32
NVL nuclear VCP-like
NXN nucleoredoxin
OPN3 opsin 3
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PELI1 pellino E3 ubiquitin protein ligase 1
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RGCC regulator of cell cycle
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SYT1 synaptotagmin I
TPD52 tumor protein D52
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
AKAP12 A kinase (PRKA) anchor protein 12
BCL6 B-cell CLL/lymphoma 6
CDCA4 cell division cycle associated 4
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CTSB cathepsin B
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
DHRS2 dehydrogenase/reductase (SDR family) member 2
DIRAS3 DIRAS family, GTP-binding RAS-like 3
ETV1 ets variant 1
FCGBP Fc fragment of IgG binding protein
GPX1 glutathione peroxidase 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
IFI16 interferon, gamma-inducible protein 16
IL6ST interleukin 6 signal transducer
LAMC1 laminin, gamma 1 (formerly LAMB2)
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MATN2 matrilin 2
MT1E metallothionein 1E
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MXRA5 matrix-remodelling associated 5
PLAT plasminogen activator, tissue
RPS11 ribosomal protein S11
SORD sorbitol dehydrogenase
SRPX sushi-repeat containing protein, X-linked
STC1 stanniocalcin 1
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
ZDHHC6 zinc finger, DHHC-type containing 6