BRD-K76042595_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

124 genes differentially expressed following the BRD-K76042595_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BTG1 B-cell translocation gene 1, anti-proliferative
CBS cystathionine-beta-synthase
CCNG2 cyclin G2
CD24 CD24 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD44 CD44 molecule (Indian blood group)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEP57 centrosomal protein 57kDa
CFB complement factor B
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHN2 chimerin 2
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL6A3 collagen, type VI, alpha 3
CPE carboxypeptidase E
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
FN1 fibronectin 1
GREM1 gremlin 1, DAN family BMP antagonist
GULP1 GULP, engulfment adaptor PTB domain containing 1
HIST1H1C histone cluster 1, H1c
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HTRA1 HtrA serine peptidase 1
KRT15 keratin 15, type I
L1CAM L1 cell adhesion molecule
LGALS8 lectin, galactoside-binding, soluble, 8
LITAF lipopolysaccharide-induced TNF factor
LYZ lysozyme
MKNK1 MAP kinase interacting serine/threonine kinase 1
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MT1E metallothionein 1E
MTSS1 metastasis suppressor 1
NIT1 nitrilase 1
PDZK1IP1 PDZK1 interacting protein 1
PEG10 paternally expressed 10
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLK2 polo-like kinase 2
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RGS2 regulator of G-protein signaling 2
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RTN2 reticulon 2
SCGB1D2 secretoglobin, family 1D, member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SNX13 sorting nexin 13
SOD2 superoxide dismutase 2, mitochondrial
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SYNGR2 synaptogyrin 2
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFPI2 tissue factor pathway inhibitor 2
THBS2 thrombospondin 2
TMSB15A thymosin beta 15a
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TPD52L1 tumor protein D52-like 1
TRIM2 tripartite motif containing 2
VEGFA vascular endothelial growth factor A
WNT5A wingless-type MMTV integration site family, member 5A
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
AGR2 anterior gradient 2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BHLHE41 basic helix-loop-helix family, member e41
CD36 CD36 molecule (thrombospondin receptor)
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
CST3 cystatin C
CTSG cathepsin G
CXCL3 chemokine (C-X-C motif) ligand 3
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EHD1 EH-domain containing 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FKBP1B FK506 binding protein 1B, 12.6 kDa
FLNA filamin A, alpha
FOLR1 folate receptor 1 (adult)
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GPX2 glutathione peroxidase 2
GPX3 glutathione peroxidase 3
HAS2 hyaluronan synthase 2
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
ITGB1BP1 integrin beta 1 binding protein 1
KDM5D lysine (K)-specific demethylase 5D
LY6D lymphocyte antigen 6 complex, locus D
MALL mal, T-cell differentiation protein-like
MCUR1 mitochondrial calcium uniporter regulator 1
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NRN1 neuritin 1
PLEC plectin
PNMA2 paraneoplastic Ma antigen 2
PODXL podocalyxin-like
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RBMS1 RNA binding motif, single stranded interacting protein 1
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAGD Ras-related GTP binding D
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SATB1 SATB homeobox 1
SPTBN1 spectrin, beta, non-erythrocytic 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRPX sushi-repeat containing protein, X-linked
SRSF6 serine/arginine-rich splicing factor 6
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
THBD thrombomodulin
TLR4 toll-like receptor 4
TNS1 tensin 1
UPK1B uroplakin 1B