BRD-K76401790_JNK-IN-5A_A375_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

160 genes differentially expressed following the BRD-K76401790_JNK-IN-5A_A375_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADRB2 adrenoceptor beta 2, surface
AREG amphiregulin
ARL4A ADP-ribosylation factor-like 4A
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BTG3 BTG family, member 3
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CLGN calmegin
CLTB clathrin, light chain B
CTSG cathepsin G
CYR61 cysteine-rich, angiogenic inducer, 61
DUSP2 dual specificity phosphatase 2
EGR1 early growth response 1
EGR3 early growth response 3
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GSPT1 G1 to S phase transition 1
H2BFS H2B histone family, member S (pseudogene)
HBEGF heparin-binding EGF-like growth factor
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
HSPA4L heat shock 70kDa protein 4-like
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGHD immunoglobulin heavy constant delta
IGKC immunoglobulin kappa constant
KLHL21 kelch-like family member 21
LAPTM4B lysosomal protein transmembrane 4 beta
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MT1E metallothionein 1E
MT1H metallothionein 1H
MYC v-myc avian myelocytomatosis viral oncogene homolog
NR4A3 nuclear receptor subfamily 4, group A, member 3
ODC1 ornithine decarboxylase 1
OLFM4 olfactomedin 4
PAWR PRKC, apoptosis, WT1, regulator
PLAC8 placenta-specific 8
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
REXO2 RNA exonuclease 2
RGS2 regulator of G-protein signaling 2
SCGB1D2 secretoglobin, family 1D, member 2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SESN1 sestrin 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SOX9 SRY (sex determining region Y)-box 9
TARP TCR gamma alternate reading frame protein
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
XK X-linked Kx blood group
ZNHIT6 zinc finger, HIT-type containing 6
ZW10 zw10 kinetochore protein

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ACOX2 acyl-CoA oxidase 2, branched chain
ACTA1 actin, alpha 1, skeletal muscle
AGTR1 angiotensin II receptor, type 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANGPT1 angiopoietin 1
AQP3 aquaporin 3 (Gill blood group)
ASPH aspartate beta-hydroxylase
ATXN1 ataxin 1
BCL6 B-cell CLL/lymphoma 6
BIN1 bridging integrator 1
BPIFA1 BPI fold containing family A, member 1
C1RL complement component 1, r subcomponent-like
C3 complement component 3
CD58 CD58 molecule
CD9 CD9 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CES1 carboxylesterase 1
CFI complement factor I
CLDN10 claudin 10
CXCL14 chemokine (C-X-C motif) ligand 14
CYBA cytochrome b-245, alpha polypeptide
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DHRS3 dehydrogenase/reductase (SDR family) member 3
DMBT1 deleted in malignant brain tumors 1
DPYSL3 dihydropyrimidinase-like 3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB3 erb-b2 receptor tyrosine kinase 3
ETV1 ets variant 1
FXYD3 FXYD domain containing ion transport regulator 3
FZD7 frizzled class receptor 7
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GLRX glutaredoxin (thioltransferase)
GSTT1 glutathione S-transferase theta 1
HMGA2 high mobility group AT-hook 2
HSPA1A heat shock 70kDa protein 1A
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
KANK1 KN motif and ankyrin repeat domains 1
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
LAMB1 laminin, beta 1
LPAR1 lysophosphatidic acid receptor 1
MDH1 malate dehydrogenase 1, NAD (soluble)
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MPZL2 myelin protein zero-like 2
NDN necdin, melanoma antigen (MAGE) family member
NES nestin
NPY neuropeptide Y
NUSAP1 nucleolar and spindle associated protein 1
OXA1L oxidase (cytochrome c) assembly 1-like
PACSIN2 protein kinase C and casein kinase substrate in neurons 2
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PGM1 phosphoglucomutase 1
PLIN2 perilipin 2
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRDX2 peroxiredoxin 2
PRUNE2 prune homolog 2 (Drosophila)
QPCT glutaminyl-peptide cyclotransferase
RGL1 ral guanine nucleotide dissociation stimulator-like 1
SCAND1 SCAN domain containing 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SHB Src homology 2 domain containing adaptor protein B
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPRR3 small proline-rich protein 3
SPTSSA serine palmitoyltransferase, small subunit A
STATH statherin
SYT1 synaptotagmin I
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TF transferrin
TGFBI transforming growth factor, beta-induced, 68kDa
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TMEM100 transmembrane protein 100
TMEM2 transmembrane protein 2
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIB2 tribbles pseudokinase 2
UBE2A ubiquitin-conjugating enzyme E2A
VCAM1 vascular cell adhesion molecule 1
WFDC2 WAP four-disulfide core domain 2
WNT5A wingless-type MMTV integration site family, member 5A
WWTR1 WW domain containing transcription regulator 1
Funding