BRD-K76401790_JNK-IN-5A_A375_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

142 genes differentially expressed following the BRD-K76401790_JNK-IN-5A_A375_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADRB2 adrenoceptor beta 2, surface
ANXA3 annexin A3
ATF3 activating transcription factor 3
BMP2 bone morphogenetic protein 2
BTG3 BTG family, member 3
CAV1 caveolin 1, caveolae protein, 22kDa
CCND1 cyclin D1
CDC25A cell division cycle 25A
CSRP1 cysteine and glycine-rich protein 1
CUX2 cut-like homeobox 2
CXCL11 chemokine (C-X-C motif) ligand 11
CYR61 cysteine-rich, angiogenic inducer, 61
DUSP7 dual specificity phosphatase 7
EGR1 early growth response 1
ESR1 estrogen receptor 1
EZR ezrin
F3 coagulation factor III (thromboplastin, tissue factor)
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GBP1 guanylate binding protein 1, interferon-inducible
H2BFS H2B histone family, member S (pseudogene)
HACD1 3-hydroxyacyl-CoA dehydratase 1
HBEGF heparin-binding EGF-like growth factor
HDAC9 histone deacetylase 9
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H4H histone cluster 1, H4h
HIST3H2A histone cluster 3, H2a
HSPA4L heat shock 70kDa protein 4-like
KCTD5 potassium channel tetramerization domain containing 5
KLHL21 kelch-like family member 21
LAMC2 laminin, gamma 2
LAPTM4B lysosomal protein transmembrane 4 beta
LMO4 LIM domain only 4
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
MEIS1 Meis homeobox 1
MMP9 matrix metallopeptidase 9
MT1E metallothionein 1E
MYC v-myc avian myelocytomatosis viral oncogene homolog
ODC1 ornithine decarboxylase 1
OXSR1 oxidative stress responsive 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PODXL podocalyxin-like
RGS2 regulator of G-protein signaling 2
SCGB1D2 secretoglobin, family 1D, member 2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SESN1 sestrin 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC35F2 solute carrier family 35, member F2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPM4 tropomyosin 4
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
XIST X inactive specific transcript (non-protein coding)
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZNF652 zinc finger protein 652
ZW10 zw10 kinetochore protein

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
AHR aryl hydrocarbon receptor
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDOA aldolase A, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
ASPH aspartate beta-hydroxylase
BICC1 BicC family RNA binding protein 1
CADM1 cell adhesion molecule 1
CAT catalase
CD24 CD24 molecule
CD58 CD58 molecule
CFI complement factor I
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A3 collagen, type VI, alpha 3
CXCL12 chemokine (C-X-C motif) ligand 12
CYB5A cytochrome b5 type A (microsomal)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPYSL3 dihydropyrimidinase-like 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB3 erb-b2 receptor tyrosine kinase 3
FABP7 fatty acid binding protein 7, brain
FGG fibrinogen gamma chain
FXYD2 FXYD domain containing ion transport regulator 2
FZD7 frizzled class receptor 7
GLRX glutaredoxin (thioltransferase)
GNAS GNAS complex locus
GPX2 glutathione peroxidase 2
HOXA5 homeobox A5
HSPA1A heat shock 70kDa protein 1A
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IGFBP4 insulin-like growth factor binding protein 4
JAG1 jagged 1
LAMB1 laminin, beta 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MAN1A1 mannosidase, alpha, class 1A, member 1
MARCKSL1 MARCKS-like 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NRP1 neuropilin 1
PGM1 phosphoglucomutase 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PON2 paraoxonase 2
PPAP2B phosphatidic acid phosphatase type 2B
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRDX2 peroxiredoxin 2
PSD3 pleckstrin and Sec7 domain containing 3
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A7 S100 calcium binding protein A7
SFRP1 secreted frizzled-related protein 1
SKAP2 src kinase associated phosphoprotein 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK1 serine peptidase inhibitor, Kazal type 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TF transferrin
THBS2 thrombospondin 2
TMEM2 transmembrane protein 2
TMEM255A transmembrane protein 255A
TMX4 thioredoxin-related transmembrane protein 4
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIM2 tripartite motif containing 2
TTC9 tetratricopeptide repeat domain 9
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UGP2 UDP-glucose pyrophosphorylase 2
WWTR1 WW domain containing transcription regulator 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
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