BRD-K76401790_JNK-IN-5A_HCC515_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

89 genes differentially expressed following the BRD-K76401790_JNK-IN-5A_HCC515_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTG2 actin, gamma 2, smooth muscle, enteric
APOD apolipoprotein D
AQP1 aquaporin 1 (Colton blood group)
AREG amphiregulin
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
AZGP1 alpha-2-glycoprotein 1, zinc-binding
C6ORF62 chromosome 6 open reading frame 62
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCNA2 cyclin A2
CCNB2 cyclin B2
CDA cytidine deaminase
CDC20 cell division cycle 20
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CLTB clathrin, light chain B
CRIP2 cysteine-rich protein 2
CSRP1 cysteine and glycine-rich protein 1
CUX2 cut-like homeobox 2
CXCL12 chemokine (C-X-C motif) ligand 12
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DKK3 dickkopf WNT signaling pathway inhibitor 3
FKBP5 FK506 binding protein 5
FOSL1 FOS-like antigen 1
HEPH hephaestin
HOXB6 homeobox B6
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP6 insulin-like growth factor binding protein 6
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IKZF1 IKAROS family zinc finger 1 (Ikaros)
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
LMO3 LIM domain only 3 (rhombotin-like 2)
METTL7A methyltransferase like 7A
MYH11 myosin, heavy chain 11, smooth muscle
NDC80 NDC80 kinetochore complex component
PBK PDZ binding kinase
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLK1 polo-like kinase 1
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SMTN smoothelin
SORBS1 sorbin and SH3 domain containing 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TPM1 tropomyosin 1 (alpha)
TXNIP thioredoxin interacting protein
UBE2S ubiquitin-conjugating enzyme E2S
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZNF185 zinc finger protein 185 (LIM domain)

decreased expression

Symbol Name
ADGRL2 adhesion G protein-coupled receptor L2
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATM ATM serine/threonine kinase
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
CCL20 chemokine (C-C motif) ligand 20
CFB complement factor B
COL3A1 collagen, type III, alpha 1
CSTA cystatin A (stefin A)
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
GATA6 GATA binding protein 6
GJA1 gap junction protein, alpha 1, 43kDa
HBB hemoglobin, beta
HES1 hes family bHLH transcription factor 1
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
KRT19 keratin 19, type I
LCN2 lipocalin 2
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MFSD10 major facilitator superfamily domain containing 10
MX1 MX dynamin-like GTPase 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NUPR1 nuclear protein, transcriptional regulator, 1
PLA2G16 phospholipase A2, group XVI
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
TACSTD2 tumor-associated calcium signal transducer 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPD52L1 tumor protein D52-like 1
VAV3 vav 3 guanine nucleotide exchange factor
ZNF652 zinc finger protein 652
Funding