BRD-K76401790_JNK-IN-5A_PC3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

159 genes differentially expressed following the BRD-K76401790_JNK-IN-5A_PC3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACP5 acid phosphatase 5, tartrate resistant
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ATHL1 ATH1, acid trehalase-like 1 (yeast)
AURKA aurora kinase A
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCND2 cyclin D2
CHIC2 cysteine-rich hydrophobic domain 2
COL9A3 collagen, type IX, alpha 3
CTGF connective tissue growth factor
CTSZ cathepsin Z
CXCL2 chemokine (C-X-C motif) ligand 2
CXCR4 chemokine (C-X-C motif) receptor 4
DLC1 DLC1 Rho GTPase activating protein
DLK1 delta-like 1 homolog (Drosophila)
DSG3 desmoglein 3
DSP desmoplakin
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FXYD5 FXYD domain containing ion transport regulator 5
GAL galanin/GMAP prepropeptide
GAS6 growth arrest-specific 6
GLS glutaminase
HEPH hephaestin
HIST1H2BK histone cluster 1, H2bk
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IFITM1 interferon induced transmembrane protein 1
IGHM immunoglobulin heavy constant mu
INHBA inhibin, beta A
ITGA6 integrin, alpha 6
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
LAPTM4B lysosomal protein transmembrane 4 beta
MLXIP MLX interacting protein
MMP7 matrix metallopeptidase 7
MPP1 membrane protein, palmitoylated 1, 55kDa
MYO1D myosin ID
OLFM4 olfactomedin 4
OSBPL3 oxysterol binding protein-like 3
PCDH9 protocadherin 9
PIEZO1 piezo-type mechanosensitive ion channel component 1
PLK1 polo-like kinase 1
PODXL podocalyxin-like
PSME4 proteasome (prosome, macropain) activator subunit 4
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
SFRP4 secreted frizzled-related protein 4
SIRT3 sirtuin 3
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
TAL1 T-cell acute lymphocytic leukemia 1
TATDN2 TatD DNase domain containing 2
TCL1A T-cell leukemia/lymphoma 1A
TEX10 testis expressed 10
THBS1 thrombospondin 1
TRPS1 trichorhinophalangeal syndrome I
UBE2S ubiquitin-conjugating enzyme E2S
XPO7 exportin 7
ZDHHC11 zinc finger, DHHC-type containing 11

decreased expression

Symbol Name
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANXA10 annexin A10
ANXA9 annexin A9
ARHGAP29 Rho GTPase activating protein 29
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
AZGP1 alpha-2-glycoprotein 1, zinc-binding
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BCL6 B-cell CLL/lymphoma 6
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CANT1 calcium activated nucleotidase 1
CASP7 caspase 7, apoptosis-related cysteine peptidase
CD36 CD36 molecule (thrombospondin receptor)
CD58 CD58 molecule
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDK1 cyclin-dependent kinase 1
CLU clusterin
COL3A1 collagen, type III, alpha 1
CPD carboxypeptidase D
CRIP1 cysteine-rich protein 1 (intestinal)
CYB5A cytochrome b5 type A (microsomal)
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP6 dual specificity phosphatase 6
ECHDC2 enoyl CoA hydratase domain containing 2
EMP1 epithelial membrane protein 1
ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative)
ETV1 ets variant 1
FAM3C family with sequence similarity 3, member C
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FXYD3 FXYD domain containing ion transport regulator 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GDF15 growth differentiation factor 15
GINS1 GINS complex subunit 1 (Psf1 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
GPX3 glutathione peroxidase 3
GSTA4 glutathione S-transferase alpha 4
GSTT1 glutathione S-transferase theta 1
HBB hemoglobin, beta
HILPDA hypoxia inducible lipid droplet-associated
HNMT histamine N-methyltransferase
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFI6 interferon, alpha-inducible protein 6
IL1B interleukin 1, beta
KDM5D lysine (K)-specific demethylase 5D
KLF4 Kruppel-like factor 4 (gut)
KRT13 keratin 13, type I
KRT19 keratin 19, type I
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LRRC17 leucine rich repeat containing 17
MAGED1 melanoma antigen family D1
MCM6 minichromosome maintenance complex component 6
MDK midkine (neurite growth-promoting factor 2)
MMD monocyte to macrophage differentiation-associated
NAMPT nicotinamide phosphoribosyltransferase
NID1 nidogen 1
NREP neuronal regeneration related protein
OSBPL1A oxysterol binding protein-like 1A
PALMD palmdelphin
PCNA proliferating cell nuclear antigen
PEG10 paternally expressed 10
PLA2G16 phospholipase A2, group XVI
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLIN2 perilipin 2
PPIC peptidylprolyl isomerase C (cyclophilin C)
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RNASE4 ribonuclease, RNase A family, 4
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SPAG4 sperm associated antigen 4
SPATS2L spermatogenesis associated, serine-rich 2-like
SRSF7 serine/arginine-rich splicing factor 7
STEAP1 six transmembrane epithelial antigen of the prostate 1
TF transferrin
TMEM14A transmembrane protein 14A
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TMEM45A transmembrane protein 45A
TMX4 thioredoxin-related transmembrane protein 4
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
TOPBP1 topoisomerase (DNA) II binding protein 1
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
VCAM1 vascular cell adhesion molecule 1
WWTR1 WW domain containing transcription regulator 1
YME1L1 YME1-like 1 ATPase
ZWINT ZW10 interacting kinetochore protein
Funding