BRD-K76674262_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

358 genes differentially expressed following the BRD-K76674262_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ADNP2 ADNP homeobox 2
AKAP12 A kinase (PRKA) anchor protein 12
ARC activity-regulated cytoskeleton-associated protein
AREG amphiregulin
ARFIP2 ADP-ribosylation factor interacting protein 2
ARID4A AT rich interactive domain 4A (RBP1-like)
ARID4B AT rich interactive domain 4B (RBP1-like)
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1
ARL14 ADP-ribosylation factor-like 14
ATF3 activating transcription factor 3
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BAG3 BCL2-associated athanogene 3
BCAS2 breast carcinoma amplified sequence 2
BCL3 B-cell CLL/lymphoma 3
BRD2 bromodomain containing 2
BTG1 B-cell translocation gene 1, anti-proliferative
BTG3 BTG family, member 3
CADM1 cell adhesion molecule 1
CCNL1 cyclin L1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2AIP CDKN2A interacting protein
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CEP192 centrosomal protein 192kDa
CHD1 chromodomain helicase DNA binding protein 1
CHIC2 cysteine-rich hydrophobic domain 2
CHMP1B charged multivesicular body protein 1B
CLDN18 claudin 18
CLK4 CDC-like kinase 4
CNOT4 CCR4-NOT transcription complex, subunit 4
COL11A1 collagen, type XI, alpha 1
COL5A2 collagen, type V, alpha 2
COL9A3 collagen, type IX, alpha 3
COMP cartilage oligomeric matrix protein
COQ10B coenzyme Q10 homolog B (S. cerevisiae)
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYLD cylindromatosis (turban tumor syndrome)
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLX2 distal-less homeobox 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DUSP8 dual specificity phosphatase 8
EGR1 early growth response 1
EGR3 early growth response 3
ELF1 E74-like factor 1 (ets domain transcription factor)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EREG epiregulin
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
EZR ezrin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM13B family with sequence similarity 13, member B
FAM46A family with sequence similarity 46, member A
FAM53C family with sequence similarity 53, member C
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL2 four and a half LIM domains 2
FKBP14 FK506 binding protein 14, 22 kDa
FLRT3 fibronectin leucine rich transmembrane protein 3
FNBP4 formin binding protein 4
FNDC3B fibronectin type III domain containing 3B
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXO3 forkhead box O3
GADD45B growth arrest and DNA-damage-inducible, beta
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSTM3 glutathione S-transferase mu 3 (brain)
GTF2B general transcription factor IIB
GTPBP8 GTP-binding protein 8 (putative)
H1F0 H1 histone family, member 0
H2BFS H2B histone family, member S (pseudogene)
HBP1 HMG-box transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BI histone cluster 1, H2bi
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXA5 homeobox A5
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IL11 interleukin 11
IL6 interleukin 6
IL6ST interleukin 6 signal transducer
ING3 inhibitor of growth family, member 3
INTS6 integrator complex subunit 6
IRF1 interferon regulatory factor 1
ISG20 interferon stimulated exonuclease gene 20kDa
ITCH itchy E3 ubiquitin protein ligase
JMJD1C jumonji domain containing 1C
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM5A lysine (K)-specific demethylase 5A
KDM5B lysine (K)-specific demethylase 5B
KDM6A lysine (K)-specific demethylase 6A
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
LDLR low density lipoprotein receptor
LGALS8 lectin, galactoside-binding, soluble, 8
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MCL1 myeloid cell leukemia 1
MED17 mediator complex subunit 17
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MIR22HG MIR22 host gene
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NMB neuromedin B
NOTCH2NL notch 2 N-terminal like
NR1D2 nuclear receptor subfamily 1, group D, member 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUP98 nucleoporin 98kDa
NUPL1 nucleoporin like 1
NXF1 nuclear RNA export factor 1
ODC1 ornithine decarboxylase 1
OSER1 oxidative stress responsive serine-rich 1
PER1 period circadian clock 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAU plasminogen activator, urokinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSME4 proteasome (prosome, macropain) activator subunit 4
PTBP2 polypyrimidine tract binding protein 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTPN2 protein tyrosine phosphatase, non-receptor type 2
QKI QKI, KH domain containing, RNA binding
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RB1CC1 RB1-inducible coiled-coil 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RLF rearranged L-myc fusion
RND1 Rho family GTPase 1
RNF114 ring finger protein 114
RNMT RNA (guanine-7-) methyltransferase
RPL37A ribosomal protein L37a
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RSRC2 arginine/serine-rich coiled-coil 2
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCAF8 SR-related CTD-associated factor 8
SCYL3 SCY1-like 3 (S. cerevisiae)
SEC24A SEC24 family member A
SFRP4 secreted frizzled-related protein 4
SLC16A4 solute carrier family 16, member 4
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SMAD3 SMAD family member 3
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SON SON DNA binding protein
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPAG9 sperm associated antigen 9
SQSTM1 sequestosome 1
SRPK2 SRSF protein kinase 2
SRSF7 serine/arginine-rich splicing factor 7
SSFA2 sperm specific antigen 2
STAR steroidogenic acute regulatory protein
STK17A serine/threonine kinase 17a
STK38L serine/threonine kinase 38 like
STX1A syntaxin 1A (brain)
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
THUMPD2 THUMP domain containing 2
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TMF1 TATA element modulatory factor 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRA2A transformer 2 alpha homolog (Drosophila)
TSC22D2 TSC22 domain family, member 2
TSG101 tumor susceptibility 101
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
UBAP1 ubiquitin associated protein 1
UBE2B ubiquitin-conjugating enzyme E2B
UBE2H ubiquitin-conjugating enzyme E2H
UBXN7 UBX domain protein 7
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
WSB1 WD repeat and SOCS box containing 1
XIST X inactive specific transcript (non-protein coding)
YTHDC1 YTH domain containing 1
ZBTB43 zinc finger and BTB domain containing 43
ZFP36 ZFP36 ring finger protein
ZNF165 zinc finger protein 165
ZNF222 zinc finger protein 222
ZNF274 zinc finger protein 274
ZNF432 zinc finger protein 432
ZNF451 zinc finger protein 451
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ACTC1 actin, alpha, cardiac muscle 1
ADIRF adipogenesis regulatory factor
AHNAK2 AHNAK nucleoprotein 2
AIDA axin interactor, dorsalization associated
AIM1 absent in melanoma 1
AKAP1 A kinase (PRKA) anchor protein 1
ALG6 ALG6, alpha-1,3-glucosyltransferase
ALOX5 arachidonate 5-lipoxygenase
ANPEP alanyl (membrane) aminopeptidase
ARF3 ADP-ribosylation factor 3
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
B3GNT1
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BCAP31 B-cell receptor-associated protein 31
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BMP4 bone morphogenetic protein 4
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CANT1 calcium activated nucleotidase 1
CBX6 chromobox homolog 6
CCNA2 cyclin A2
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CDK4 cyclin-dependent kinase 4
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CLCA4 chloride channel accessory 4
CP ceruloplasmin (ferroxidase)
CRABP2 cellular retinoic acid binding protein 2
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
DEFB1 defensin, beta 1
DES desmin
DHRS1 dehydrogenase/reductase (SDR family) member 1
DPYSL2 dihydropyrimidinase-like 2
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1
EIF4B eukaryotic translation initiation factor 4B
ERBB2 erb-b2 receptor tyrosine kinase 2
ESD esterase D
ESR1 estrogen receptor 1
FAM129A family with sequence similarity 129, member A
FAM134A family with sequence similarity 134, member A
FBLN1 fibulin 1
FCGBP Fc fragment of IgG binding protein
FHL1 four and a half LIM domains 1
G6PD glucose-6-phosphate dehydrogenase
GAS1 growth arrest-specific 1
GCLM glutamate-cysteine ligase, modifier subunit
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GNAS GNAS complex locus
GPC4 glypican 4
GPNMB glycoprotein (transmembrane) nmb
GSN gelsolin
GTF3A general transcription factor IIIA
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HMGB3 high mobility group box 3
HMGN4 high mobility group nucleosomal binding domain 4
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ICMT isoprenylcysteine carboxyl methyltransferase
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDO1 indoleamine 2,3-dioxygenase 1
IFI16 interferon, gamma-inducible protein 16
IPO5 importin 5
IRAK1 interleukin-1 receptor-associated kinase 1
JAG2 jagged 2
KANK2 KN motif and ankyrin repeat domains 2
KAZN kazrin, periplakin interacting protein
KCTD12 potassium channel tetramerization domain containing 12
LAMP1 lysosomal-associated membrane protein 1
LBR lamin B receptor
LRP10 low density lipoprotein receptor-related protein 10
MFSD5 major facilitator superfamily domain containing 5
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
MGLL monoglyceride lipase
MLEC malectin
MME membrane metallo-endopeptidase
MPZL2 myelin protein zero-like 2
MREG melanoregulin
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
NDRG2 NDRG family member 2
NEFH neurofilament, heavy polypeptide
NMU neuromedin U
NUP62 nucleoporin 62kDa
NXN nucleoredoxin
OLFM4 olfactomedin 4
PARP1 poly (ADP-ribose) polymerase 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCP4 Purkinje cell protein 4
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PDZK1IP1 PDZK1 interacting protein 1
PEBP1 phosphatidylethanolamine binding protein 1
PEG10 paternally expressed 10
PKP4 plakophilin 4
PLBD1 phospholipase B domain containing 1
PODXL podocalyxin-like
PPL periplakin
PRUNE2 prune homolog 2 (Drosophila)
PSAT1 phosphoserine aminotransferase 1
PTGIS prostaglandin I2 (prostacyclin) synthase
RAB15 RAB15, member RAS oncogene family
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RNF130 ring finger protein 130
RPA1 replication protein A1, 70kDa
RPIA ribose 5-phosphate isomerase A
RPS4Y1 ribosomal protein S4, Y-linked 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SFN stratifin
SH3BGRL SH3 domain binding glutamate-rich protein like
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SMAD1 SMAD family member 1
SPON2 spondin 2, extracellular matrix protein
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D16 TBC1 domain family, member 16
TKT transketolase
TMEM109 transmembrane protein 109
TMEM97 transmembrane protein 97
TMPO thymopoietin
TNS1 tensin 1
TPD52L1 tumor protein D52-like 1
TRIM14 tripartite motif containing 14
TUBB tubulin, beta class I
UBAC1 UBA domain containing 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
Funding