BRD-K76694128_DCC-2036_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

186 genes differentially expressed following the BRD-K76694128_DCC-2036_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
AHNAK AHNAK nucleoprotein
AIM2 absent in melanoma 2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA1 annexin A1
AP2B1 adaptor-related protein complex 2, beta 1 subunit
ARF1 ADP-ribosylation factor 1
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAG3 BCL2-associated athanogene 3
BBX bobby sox homolog (Drosophila)
BCL10 B-cell CLL/lymphoma 10
BST2 bone marrow stromal cell antigen 2
CAB39 calcium binding protein 39
CD36 CD36 molecule (thrombospondin receptor)
CD48 CD48 molecule
CD52 CD52 molecule
CD53 CD53 molecule
CDC42 cell division cycle 42
CLDN8 claudin 8
CTSL cathepsin L
CTSZ cathepsin Z
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
CXCR4 chemokine (C-X-C motif) receptor 4
DEGS1 delta(4)-desaturase, sphingolipid 1
DUSP14 dual specificity phosphatase 14
DUSP22 dual specificity phosphatase 22
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
FGF13 fibroblast growth factor 13
FLNB filamin B, beta
GLIPR1 GLI pathogenesis-related 1
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GOLM1 golgi membrane protein 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IL7R interleukin 7 receptor
ITGB5 integrin, beta 5
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KCTD9 potassium channel tetramerization domain containing 9
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT6B keratin 6B, type II
LAMC1 laminin, gamma 1 (formerly LAMB2)
LEF1 lymphoid enhancer-binding factor 1
LIMS1 LIM and senescent cell antigen-like domains 1
LPL lipoprotein lipase
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP2K1 mitogen-activated protein kinase kinase 1
MCL1 myeloid cell leukemia 1
MCTP1 multiple C2 domains, transmembrane 1
MMP7 matrix metallopeptidase 7
MPPED2 metallophosphoesterase domain containing 2
MSN moesin
MT1E metallothionein 1E
NOTCH2 notch 2
NPTN neuroplastin
PDIA3 protein disulfide isomerase family A, member 3
PECAM1 platelet/endothelial cell adhesion molecule 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PMEPA1 prostate transmembrane protein, androgen induced 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCH protein kinase C, eta
PRNP prion protein
PRR7 proline rich 7 (synaptic)
PTPRC protein tyrosine phosphatase, receptor type, C
RALB v-ral simian leukemia viral oncogene homolog B
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
RHOC ras homolog family member C
RNF11 ring finger protein 11
RSRP1 arginine/serine-rich protein 1
S100A4 S100 calcium binding protein A4
SDCBP syndecan binding protein (syntenin)
SELE selectin E
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERTAD2 SERTA domain containing 2
SFN stratifin
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SMS spermine synthase
SPARCL1 SPARC-like 1 (hevin)
TARP TCR gamma alternate reading frame protein
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM9SF3 transmembrane 9 superfamily member 3
TOMM34 translocase of outer mitochondrial membrane 34
TXNIP thioredoxin interacting protein
UGCG UDP-glucose ceramide glucosyltransferase
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VGLL4 vestigial-like family member 4

decreased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
AFP alpha-fetoprotein
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHCY adenosylhomocysteinase
AKAP1 A kinase (PRKA) anchor protein 1
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALOX5 arachidonate 5-lipoxygenase
BEX1 brain expressed, X-linked 1
C3 complement component 3
C4BPA complement component 4 binding protein, alpha
CAPN3 calpain 3, (p94)
CBS cystathionine-beta-synthase
CCNA2 cyclin A2
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CDC25B cell division cycle 25B
CDK4 cyclin-dependent kinase 4
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CES1 carboxylesterase 1
CHMP4A charged multivesicular body protein 4A
COA3 cytochrome c oxidase assembly factor 3
COL16A1 collagen, type XVI, alpha 1
COMT catechol-O-methyltransferase
DLK1 delta-like 1 homolog (Drosophila)
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ELN elastin
EPS8L2 EPS8-like 2
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FABP7 fatty acid binding protein 7, brain
FADS1 fatty acid desaturase 1
FAM57A family with sequence similarity 57, member A
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FGFR4 fibroblast growth factor receptor 4
FOLR1 folate receptor 1 (adult)
FTH1 ferritin, heavy polypeptide 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GDF15 growth differentiation factor 15
HMOX1 heme oxygenase 1
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IPO13 importin 13
IPO4 importin 4
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KRT19 keratin 19, type I
KRT7 keratin 7, type II
LCN2 lipocalin 2
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LOC100505650 uncharacterized LOC100505650
MEG3 maternally expressed 3 (non-protein coding)
MRPL12 mitochondrial ribosomal protein L12
MRPL57 mitochondrial ribosomal protein L57
MUC16 mucin 16, cell surface associated
N4BP2L2 NEDD4 binding protein 2-like 2
NEB nebulin
NIPSNAP1 nipsnap homolog 1 (C. elegans)
ORM1 orosomucoid 1
OXA1L oxidase (cytochrome c) assembly 1-like
PDE4DIP phosphodiesterase 4D interacting protein
PNMA2 paraneoplastic Ma antigen 2
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PROM1 prominin 1
PXDN peroxidasin
QPRT quinolinate phosphoribosyltransferase
RPIA ribose 5-phosphate isomerase A
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG5 secretogranin V
SCGB2A1 secretoglobin, family 2A, member 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SPINK1 serine peptidase inhibitor, Kazal type 1
STRA13 stimulated by retinoic acid 13
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIB3 tribbles pseudokinase 3
TRIP6 thyroid hormone receptor interactor 6
TSPYL5 TSPY-like 5
TTN titin
TYMS thymidylate synthetase
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VTCN1 V-set domain containing T cell activation inhibitor 1
ZDHHC13 zinc finger, DHHC-type containing 13
ZIC1 Zic family member 1
Funding