BRD-K76964878_EX-527_HA1E_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

115 genes differentially expressed following the BRD-K76964878_EX-527_HA1E_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADAM28 ADAM metallopeptidase domain 28
ALAS1 5'-aminolevulinate synthase 1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANOS1 anosmin 1
ASPN asporin
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BTG2 BTG family, member 2
CD36 CD36 molecule (thrombospondin receptor)
CD38 CD38 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CES1 carboxylesterase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC2B C-type lectin domain family 2, member B
CORO1A coronin, actin binding protein, 1A
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CTTN cortactin
CXCR4 chemokine (C-X-C motif) receptor 4
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
EPAS1 endothelial PAS domain protein 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FABP4 fatty acid binding protein 4, adipocyte
FAM107A family with sequence similarity 107, member A
FAM198B family with sequence similarity 198, member B
FBN1 fibrillin 1
FLRT2 fibronectin leucine rich transmembrane protein 2
FLRT3 fibronectin leucine rich transmembrane protein 3
GATA6 GATA binding protein 6
GPRC5B G protein-coupled receptor, class C, group 5, member B
GUSBP11 glucuronidase, beta pseudogene 11
HBB hemoglobin, beta
HCLS1 hematopoietic cell-specific Lyn substrate 1
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IL6ST interleukin 6 signal transducer
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KANK1 KN motif and ankyrin repeat domains 1
LAMP3 lysosomal-associated membrane protein 3
LAMP5 lysosomal-associated membrane protein family, member 5
LRRC17 leucine rich repeat containing 17
MEF2C myocyte enhancer factor 2C
MFAP5 microfibrillar associated protein 5
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
NMU neuromedin U
OGN osteoglycin
POSTN periostin, osteoblast specific factor
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RFTN1 raftlin, lipid raft linker 1
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
SCARB2 scavenger receptor class B, member 2
SDC1 syndecan 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLAMF7 SLAM family member 7
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLPI secretory leukocyte peptidase inhibitor
SNAI2 snail family zinc finger 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TACSTD2 tumor-associated calcium signal transducer 2
TCF4 transcription factor 4
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGFB3 transforming growth factor, beta 3
VDAC1 voltage-dependent anion channel 1
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
VWF von Willebrand factor
ZFP36 ZFP36 ring finger protein
ZNF318 zinc finger protein 318

decreased expression

Symbol Name
ACOX2 acyl-CoA oxidase 2, branched chain
AK4 adenylate kinase 4
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AP2M1 adaptor-related protein complex 2, mu 1 subunit
ARF3 ADP-ribosylation factor 3
ARMCX6 armadillo repeat containing, X-linked 6
CAPZB capping protein (actin filament) muscle Z-line, beta
CDC123 cell division cycle 123
CHN2 chimerin 2
CST1 cystatin SN
CXCL5 chemokine (C-X-C motif) ligand 5
CYB5A cytochrome b5 type A (microsomal)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
ENO1 enolase 1, (alpha)
ENO2 enolase 2 (gamma, neuronal)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ESR1 estrogen receptor 1
FAM162A family with sequence similarity 162, member A
GPRC5A G protein-coupled receptor, class C, group 5, member A
H1F0 H1 histone family, member 0
IFITM1 interferon induced transmembrane protein 1
MT1G metallothionein 1G
NDN necdin, melanoma antigen (MAGE) family member
NME1 NME/NM23 nucleoside diphosphate kinase 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
PDLIM5 PDZ and LIM domain 5
PGAM1 phosphoglycerate mutase 1 (brain)
PKM pyruvate kinase, muscle
PLAU plasminogen activator, urokinase
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
S100A10 S100 calcium binding protein A10
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
TGFBI transforming growth factor, beta-induced, 68kDa
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TNC tenascin C
TPI1 triosephosphate isomerase 1
WBP5 WW domain binding protein 5
Funding