BRD-K77480336_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

179 genes differentially expressed following the BRD-K77480336_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA2 actin, alpha 2, smooth muscle, aorta
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BASP1 brain abundant, membrane attached signal protein 1
BAX BCL2-associated X protein
BCL2A1 BCL2-related protein A1
BIRC3 baculoviral IAP repeat containing 3
BTG2 BTG family, member 2
CCDC92 coiled-coil domain containing 92
CCL2 chemokine (C-C motif) ligand 2
CCL5 chemokine (C-C motif) ligand 5
CCL8 chemokine (C-C motif) ligand 8
CD36 CD36 molecule (thrombospondin receptor)
CD83 CD83 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
CTSZ cathepsin Z
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL8 chemokine (C-X-C motif) ligand 8
CYBB cytochrome b-245, beta polypeptide
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT3 DNA-damage-inducible transcript 3
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DRAM1 DNA-damage regulated autophagy modulator 1
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
EHD1 EH-domain containing 1
ERAP2 endoplasmic reticulum aminopeptidase 2
FADS3 fatty acid desaturase 3
FAS Fas cell surface death receptor
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FDXR ferredoxin reductase
FHL2 four and a half LIM domains 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GCH1 GTP cyclohydrolase 1
GDF15 growth differentiation factor 15
GFPT2 glutamine-fructose-6-phosphate transaminase 2
HMOX1 heme oxygenase 1
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
ICAM1 intercellular adhesion molecule 1
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IL32 interleukin 32
IL6 interleukin 6
JUN jun proto-oncogene
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA0226L KIAA0226-like
LAMB3 laminin, beta 3
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LDB3 LIM domain binding 3
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MIR22HG MIR22 host gene
MKNK2 MAP kinase interacting serine/threonine kinase 2
MMP12 matrix metallopeptidase 12
NEFL neurofilament, light polypeptide
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NINJ1 ninjurin 1
OGFRL1 opioid growth factor receptor-like 1
OPTN optineurin
PDGFA platelet-derived growth factor alpha polypeptide
PHLDA3 pleckstrin homology-like domain, family A, member 3
PLA2G15 phospholipase A2, group XV
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PSAP prosaposin
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTX3 pentraxin 3, long
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RPS27L ribosomal protein S27-like
RRAD Ras-related associated with diabetes
S100A11 S100 calcium binding protein A11
SESN1 sestrin 1
SGPP1 sphingosine-1-phosphate phosphatase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SOD2 superoxide dismutase 2, mitochondrial
SQSTM1 sequestosome 1
STAT1 signal transducer and activator of transcription 1, 91kDa
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TIGAR TP53 induced glycolysis regulatory phosphatase
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNIP1 TNFAIP3 interacting protein 1
TRIAP1 TP53 regulated inhibitor of apoptosis 1
TRIM22 tripartite motif containing 22
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ACP6 acid phosphatase 6, lysophosphatidic
ANXA1 annexin A1
ASPH aspartate beta-hydroxylase
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNB2 cyclin B2
CCNF cyclin F
CDCA3 cell division cycle associated 3
CDCA8 cell division cycle associated 8
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CENPA centromere protein A
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
CP ceruloplasmin (ferroxidase)
DAPK1 death-associated protein kinase 1
DEPDC1 DEP domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
FAM64A family with sequence similarity 64, member A
FXYD5 FXYD domain containing ion transport regulator 5
FZD7 frizzled class receptor 7
GPSM2 G-protein signaling modulator 2
GRWD1 glutamate-rich WD repeat containing 1
GTSE1 G-2 and S-phase expressed 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HJURP Holliday junction recognition protein
HMMR hyaluronan-mediated motility receptor (RHAMM)
IGFBP3 insulin-like growth factor binding protein 3
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGA6 integrin, alpha 6
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KIF14 kinesin family member 14
KIF18A kinesin family member 18A
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF4A kinesin family member 4A
LAMP5 lysosomal-associated membrane protein family, member 5
LBR lamin B receptor
LPAR6 lysophosphatidic acid receptor 6
LUM lumican
MDFIC MyoD family inhibitor domain containing
MEIS2 Meis homeobox 2
MKI67 marker of proliferation Ki-67
NDC80 NDC80 kinetochore complex component
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
PAM peptidylglycine alpha-amidating monooxygenase
PBK PDZ binding kinase
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLK1 polo-like kinase 1
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PSCA prostate stem cell antigen
PSRC1 proline/serine-rich coiled-coil 1
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RGS1 regulator of G-protein signaling 1
RHOBTB3 Rho-related BTB domain containing 3
RPA3 replication protein A3, 14kDa
SDC2 syndecan 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPC25 SPC25, NDC80 kinetochore complex component
SSFA2 sperm specific antigen 2
STK39 serine threonine kinase 39
SYBU syntabulin (syntaxin-interacting)
TBC1D31 TBC1 domain family, member 31
TGFBI transforming growth factor, beta-induced, 68kDa
THY1 Thy-1 cell surface antigen
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TMSB15A thymosin beta 15a
TNC tenascin C
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TOP2A topoisomerase (DNA) II alpha 170kDa
TPBG trophoblast glycoprotein
TPM4 tropomyosin 4
TPX2 TPX2, microtubule-associated
TSEN2 TSEN2 tRNA splicing endonuclease subunit
XYLT1 xylosyltransferase I