BRD-K77547920_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

128 genes differentially expressed following the BRD-K77547920_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
AQP1 aquaporin 1 (Colton blood group)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BMP2 bone morphogenetic protein 2
C6ORF62 chromosome 6 open reading frame 62
CBS cystathionine-beta-synthase
CCND2 cyclin D2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CLC Charcot-Leyden crystal galectin
CLIC4 chloride intracellular channel 4
CLU clusterin
COL9A2 collagen, type IX, alpha 2
CXCL8 chemokine (C-X-C motif) ligand 8
DCN decorin
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DOK5 docking protein 5
EGFR epidermal growth factor receptor
EMP1 epithelial membrane protein 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FOLR1 folate receptor 1 (adult)
FXYD6 FXYD domain containing ion transport regulator 6
GPM6B glycoprotein M6B
HCAR3 hydroxycarboxylic acid receptor 3
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFITM1 interferon induced transmembrane protein 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLF4 Kruppel-like factor 4 (gut)
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
LTBP1 latent transforming growth factor beta binding protein 1
MAOB monoamine oxidase B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MMP1 matrix metallopeptidase 1
MMP3 matrix metallopeptidase 3
MMP7 matrix metallopeptidase 7
MT1M metallothionein 1M
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NPC1 Niemann-Pick disease, type C1
ODC1 ornithine decarboxylase 1
PAX8 paired box 8
PDGFA platelet-derived growth factor alpha polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEA15 phosphoprotein enriched in astrocytes 15
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PPAP2B phosphatidic acid phosphatase type 2B
PTN pleiotrophin
PTPRD protein tyrosine phosphatase, receptor type, D
RAB6A RAB6A, member RAS oncogene family
RBP4 retinol binding protein 4, plasma
RGS2 regulator of G-protein signaling 2
S100A9 S100 calcium binding protein A9
SERTAD2 SERTA domain containing 2
SFN stratifin
SLPI secretory leukocyte peptidase inhibitor
SOD2 superoxide dismutase 2, mitochondrial
TRIM29 tripartite motif containing 29
TSC22D1 TSC22 domain family, member 1
TXNRD1 thioredoxin reductase 1
UFM1 ubiquitin-fold modifier 1
WSB1 WD repeat and SOCS box containing 1

decreased expression

Symbol Name
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASPH aspartate beta-hydroxylase
AURKA aurora kinase A
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CA12 carbonic anhydrase XII
CALD1 caldesmon 1
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDK1 cyclin-dependent kinase 1
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
ERBB3 erb-b2 receptor tyrosine kinase 3
FLT3 fms-related tyrosine kinase 3
FZD2 frizzled class receptor 2
GTSE1 G-2 and S-phase expressed 1
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ICMT isoprenylcysteine carboxyl methyltransferase
IER3 immediate early response 3
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LAMB1 laminin, beta 1
MKI67 marker of proliferation Ki-67
MLEC malectin
MOK MOK protein kinase
NEK2 NIMA-related kinase 2
PLK1 polo-like kinase 1
PRC1 protein regulator of cytokinesis 1
PRSS23 protease, serine, 23
PSPH phosphoserine phosphatase
PTTG1 pituitary tumor-transforming 1
RACGAP1 Rac GTPase activating protein 1
RHOBTB3 Rho-related BTB domain containing 3
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SHCBP1 SHC SH2-domain binding protein 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S