BRD-K77547920_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

111 genes differentially expressed following the BRD-K77547920_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANXA3 annexin A3
ASNS asparagine synthetase (glutamine-hydrolyzing)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CA1 carbonic anhydrase I
CAV1 caveolin 1, caveolae protein, 22kDa
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CORO1C coronin, actin binding protein, 1C
CSTA cystatin A (stefin A)
CTSL cathepsin L
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DSG3 desmoglein 3
DST dystonin
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EGR3 early growth response 3
ELOVL6 ELOVL fatty acid elongase 6
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GCLM glutamate-cysteine ligase, modifier subunit
GUSBP11 glucuronidase, beta pseudogene 11
HBB hemoglobin, beta
HBD hemoglobin, delta
HBEGF heparin-binding EGF-like growth factor
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB1 heat shock 27kDa protein 1
HSPB8 heat shock 22kDa protein 8
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
IGKC immunoglobulin kappa constant
IRF4 interferon regulatory factor 4
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP3 matrix metallopeptidase 3
MT1F metallothionein 1F
NAMPT nicotinamide phosphoribosyltransferase
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NR4A1 nuclear receptor subfamily 4, group A, member 1
OSER1 oxidative stress responsive serine-rich 1
PDLIM5 PDZ and LIM domain 5
PPIF peptidylprolyl isomerase F
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTPRE protein tyrosine phosphatase, receptor type, E
RHOB ras homolog family member B
S100A12 S100 calcium binding protein A12
S100A2 S100 calcium binding protein A2
S100P S100 calcium binding protein P
SFN stratifin
SIK1 salt-inducible kinase 1
SORD sorbitol dehydrogenase
STK17A serine/threonine kinase 17a
TES testin LIM domain protein
TFF3 trefoil factor 3 (intestinal)
THBD thrombomodulin
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRIP6 thyroid hormone receptor interactor 6
TUFT1 tuftelin 1
UGCG UDP-glucose ceramide glucosyltransferase
UGDH UDP-glucose 6-dehydrogenase

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALDOB aldolase B, fructose-bisphosphate
BMP4 bone morphogenetic protein 4
CFI complement factor I
EDNRA endothelin receptor type A
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FAP fibroblast activation protein, alpha
FBLN1 fibulin 1
GATA2 GATA binding protein 2
GNS glucosamine (N-acetyl)-6-sulfatase
GPRC5B G protein-coupled receptor, class C, group 5, member B
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HOXA10 homeobox A10
HOXA5 homeobox A5
LRRC17 leucine rich repeat containing 17
MDK midkine (neurite growth-promoting factor 2)
MEIS1 Meis homeobox 1
MEIS2 Meis homeobox 2
NTS neurotensin
NUP107 nucleoporin 107kDa
NUSAP1 nucleolar and spindle associated protein 1
PEG10 paternally expressed 10
PRKCA protein kinase C, alpha
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SCD5 stearoyl-CoA desaturase 5
SFRP1 secreted frizzled-related protein 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPON1 spondin 1, extracellular matrix protein
VDAC1 voltage-dependent anion channel 1
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)
Funding