BRD-K77908580_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

158 genes differentially expressed following the BRD-K77908580_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADGRG1 adhesion G protein-coupled receptor G1
ADGRL2 adhesion G protein-coupled receptor L2
ADM adrenomedullin
AIM1 absent in melanoma 1
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA1 annexin A1
ANXA2 annexin A2
ANXA4 annexin A4
APOD apolipoprotein D
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BCL6 B-cell CLL/lymphoma 6
BMP4 bone morphogenetic protein 4
CAT catalase
CCNA1 cyclin A1
CD14 CD14 molecule
CD1D CD1d molecule
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CD93 CD93 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
COLEC12 collectin sub-family member 12
CRABP2 cellular retinoic acid binding protein 2
CRYAB crystallin, alpha B
CST1 cystatin SN
CTGF connective tissue growth factor
CTSZ cathepsin Z
DMD dystrophin
EDNRA endothelin receptor type A
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
ERMP1 endoplasmic reticulum metallopeptidase 1
EZR ezrin
FABP4 fatty acid binding protein 4, adipocyte
FAM13A family with sequence similarity 13, member A
FAM63A family with sequence similarity 63, member A
FHL1 four and a half LIM domains 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GATA6 GATA binding protein 6
GDF15 growth differentiation factor 15
GJA1 gap junction protein, alpha 1, 43kDa
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GPRC5B G protein-coupled receptor, class C, group 5, member B
GSN gelsolin
H2BFS H2B histone family, member S (pseudogene)
HBB hemoglobin, beta
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
IL33 interleukin 33
INHBB inhibin, beta B
ITGA6 integrin, alpha 6
JCHAIN joining chain of multimeric IgA and IgM
KCNK1 potassium channel, two pore domain subfamily K, member 1
KIAA1598
KRT18 keratin 18, type I
KRT19 keratin 19, type I
KRT23 keratin 23, type I
KRT8 keratin 8, type II
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS4 lectin, galactoside-binding, soluble, 4
LYZ lysozyme
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MARCKSL1 MARCKS-like 1
MATN2 matrilin 2
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MGP matrix Gla protein
MMP1 matrix metallopeptidase 1
MMP7 matrix metallopeptidase 7
MYH11 myosin, heavy chain 11, smooth muscle
MYLK myosin light chain kinase
MYOF myoferlin
NCALD neurocalcin delta
NCF2 neutrophil cytosolic factor 2
NFIL3 nuclear factor, interleukin 3 regulated
NR2F1 nuclear receptor subfamily 2, group F, member 1
NRCAM neuronal cell adhesion molecule
NRGN neurogranin (protein kinase C substrate, RC3)
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
P3H2 prolyl 3-hydroxylase 2
PALLD palladin, cytoskeletal associated protein
PDGFC platelet derived growth factor C
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLAT plasminogen activator, tissue
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLIN2 perilipin 2
PLN phospholamban
PRAME preferentially expressed antigen in melanoma
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTCH1 patched 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBP1 retinol binding protein 1, cellular
RGCC regulator of cell cycle
RGS10 regulator of G-protein signaling 10
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RNASE6 ribonuclease, RNase A family, k6
RTN2 reticulon 2
S100A8 S100 calcium binding protein A8
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SMAD3 SMAD family member 3
SORBS1 sorbin and SH3 domain containing 1
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPP1 secreted phosphoprotein 1
SRPX sushi-repeat containing protein, X-linked
SYNM synemin, intermediate filament protein
TACSTD2 tumor-associated calcium signal transducer 2
TBX3 T-box 3
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM45A transmembrane protein 45A
TPD52 tumor protein D52
TPD52L1 tumor protein D52-like 1
TPM2 tropomyosin 2 (beta)
TRIB2 tribbles pseudokinase 2
TUBA1A tubulin, alpha 1a
VCAN versican
WWTR1 WW domain containing transcription regulator 1

decreased expression

Symbol Name
AKAP8 A kinase (PRKA) anchor protein 8
CCND1 cyclin D1
CCND2 cyclin D2
CDC25A cell division cycle 25A
DICER1 dicer 1, ribonuclease type III
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DPT dermatopontin
HMGA2 high mobility group AT-hook 2
HSPA1A heat shock 70kDa protein 1A
IGF1R insulin-like growth factor 1 receptor
JADE2 jade family PHD finger 2
KIAA1033 KIAA1033
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
OLFML2B olfactomedin-like 2B
PURA purine-rich element binding protein A
SCEL sciellin
SPRR2B small proline-rich protein 2B
SRP72 signal recognition particle 72kDa