BRD-K77947974_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

58 genes differentially expressed following the BRD-K77947974_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
C14ORF1 chromosome 14 open reading frame 1
CD59 CD59 molecule, complement regulatory protein
CHPT1 choline phosphotransferase 1
CKS2 CDC28 protein kinase regulatory subunit 2
CLU clusterin
CST3 cystatin C
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
EMP3 epithelial membrane protein 3
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FASN fatty acid synthase
FDPS farnesyl diphosphate synthase
FTH1 ferritin, heavy polypeptide 1
GSTP1 glutathione S-transferase pi 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI27 interferon, alpha-inducible protein 27
INSIG1 insulin induced gene 1
LCN2 lipocalin 2
LDLR low density lipoprotein receptor
LPIN1 lipin 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAP7 microtubule-associated protein 7
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MSMO1 methylsterol monooxygenase 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NSDHL NAD(P) dependent steroid dehydrogenase-like
PGD phosphogluconate dehydrogenase
PTGDS prostaglandin D2 synthase 21kDa (brain)
RCN1 reticulocalbin 1, EF-hand calcium binding domain
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SQLE squalene epoxidase
SQSTM1 sequestosome 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TOB1 transducer of ERBB2, 1

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
CD93 CD93 molecule
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUOX2 dual oxidase 2
EDNRA endothelin receptor type A
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFR epidermal growth factor receptor
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
INA internexin neuronal intermediate filament protein, alpha
LRRN3 leucine rich repeat neuronal 3
MMP10 matrix metallopeptidase 10
NCAM1 neural cell adhesion molecule 1
SCGB1D2 secretoglobin, family 1D, member 2
TFPI2 tissue factor pathway inhibitor 2
TMSB15A thymosin beta 15a
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