BRD-K77947974_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

79 genes differentially expressed following the BRD-K77947974_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ACSL3 acyl-CoA synthetase long-chain family member 3
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AOX1 aldehyde oxidase 1
C7 complement component 7
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CEP57 centrosomal protein 57kDa
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
DHCR7 7-dehydrocholesterol reductase
DMD dystrophin
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAM46A family with sequence similarity 46, member A
FDPS farnesyl diphosphate synthase
FHL1 four and a half LIM domains 1
FZD7 frizzled class receptor 7
GATA6 GATA binding protein 6
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
LDLR low density lipoprotein receptor
LPIN1 lipin 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MBNL2 muscleblind-like splicing regulator 2
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MGLL monoglyceride lipase
MSMO1 methylsterol monooxygenase 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
PDZK1 PDZ domain containing 1
PTGIS prostaglandin I2 (prostacyclin) synthase
QPRT quinolinate phosphoribosyltransferase
RAB31 RAB31, member RAS oncogene family
RNMT RNA (guanine-7-) methyltransferase
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SQLE squalene epoxidase
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TSPAN8 tetraspanin 8

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
BTG3 BTG family, member 3
CP ceruloplasmin (ferroxidase)
CRABP2 cellular retinoic acid binding protein 2
CXADR coxsackie virus and adenovirus receptor
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCK deoxycytidine kinase
ECM1 extracellular matrix protein 1
EGFL6 EGF-like-domain, multiple 6
EGFR epidermal growth factor receptor
FCGBP Fc fragment of IgG binding protein
GJA1 gap junction protein, alpha 1, 43kDa
H2AFV H2A histone family, member V
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGL immunoglobulin lambda locus
KRT5 keratin 5, type II
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
OLFML2A olfactomedin-like 2A
PEA15 phosphoprotein enriched in astrocytes 15
RGCC regulator of cell cycle
SELENBP1 selenium binding protein 1
SMAD1 SMAD family member 1
SULF1 sulfatase 1
TACSTD2 tumor-associated calcium signal transducer 2
TAGLN transgelin
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
WFDC2 WAP four-disulfide core domain 2
ZNF395 zinc finger protein 395
Funding