BRD-K78062244_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

186 genes differentially expressed following the BRD-K78062244_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ACAN aggrecan
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BCL3 B-cell CLL/lymphoma 3
BGN biglycan
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
BTG3 BTG family, member 3
CCL20 chemokine (C-C motif) ligand 20
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CLU clusterin
COL2A1 collagen, type II, alpha 1
COL6A2 collagen, type VI, alpha 2
COMP cartilage oligomeric matrix protein
CTH cystathionine gamma-lyase
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CYLD cylindromatosis (turban tumor syndrome)
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EFNA1 ephrin-A1
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FADS1 fatty acid desaturase 1
FMOD fibromodulin
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FTH1 ferritin, heavy polypeptide 1
FXYD6 FXYD domain containing ion transport regulator 6
GLUL glutamate-ammonia ligase
GPI glucose-6-phosphate isomerase
HCAR3 hydroxycarboxylic acid receptor 3
HILPDA hypoxia inducible lipid droplet-associated
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IL6 interleukin 6
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLF5 Kruppel-like factor 5 (intestinal)
KLHL24 kelch-like family member 24
KTN1 kinectin 1 (kinesin receptor)
LRRC15 leucine rich repeat containing 15
LTB lymphotoxin beta (TNF superfamily, member 3)
MFAP5 microfibrillar associated protein 5
MMP1 matrix metallopeptidase 1
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
NDNF neuron-derived neurotrophic factor
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEFL neurofilament, light polypeptide
NEFM neurofilament, medium polypeptide
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
OLFML2A olfactomedin-like 2A
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PLAU plasminogen activator, urokinase
PLD3 phospholipase D family, member 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRUNE2 prune homolog 2 (Drosophila)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS16 regulator of G-protein signaling 16
SAT1 spermidine/spermine N1-acetyltransferase 1
SELE selectin E
SELENBP1 selenium binding protein 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SERTAD2 SERTA domain containing 2
SFN stratifin
SOCS2 suppressor of cytokine signaling 2
SOD2 superoxide dismutase 2, mitochondrial
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SQSTM1 sequestosome 1
STC1 stanniocalcin 1
STC2 stanniocalcin 2
TCEAL2 transcription elongation factor A (SII)-like 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNNT1 troponin T type 1 (skeletal, slow)
TSPYL5 TSPY-like 5
VEGFA vascular endothelial growth factor A
ZC3H12A zinc finger CCCH-type containing 12A
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACP6 acid phosphatase 6, lysophosphatidic
AIM1 absent in melanoma 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA6 annexin A6
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
ARF4 ADP-ribosylation factor 4
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
AURKA aurora kinase A
B3GNT1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCNA2 cyclin A2
CCNF cyclin F
CCR7 chemokine (C-C motif) receptor 7
CD200 CD200 molecule
CD59 CD59 molecule, complement regulatory protein
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDCA4 cell division cycle associated 4
CENPA centromere protein A
CHD7 chromodomain helicase DNA binding protein 7
COPS7A COP9 signalosome subunit 7A
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAAF2 dynein, axonemal, assembly factor 2
EIF4E eukaryotic translation initiation factor 4E
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FAM208A family with sequence similarity 208, member A
HES1 hes family bHLH transcription factor 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HOXA10 homeobox A10
IGHM immunoglobulin heavy constant mu
JADE2 jade family PHD finger 2
KCTD12 potassium channel tetramerization domain containing 12
LAMB1 laminin, beta 1
LGALS1 lectin, galactoside-binding, soluble, 1
LMO2 LIM domain only 2 (rhombotin-like 1)
LYPLA1 lysophospholipase I
MARCKSL1 MARCKS-like 1
MOK MOK protein kinase
MREG melanoregulin
MRPL15 mitochondrial ribosomal protein L15
MYH10 myosin, heavy chain 10, non-muscle
NAV3 neuron navigator 3
NPC2 Niemann-Pick disease, type C2
NRIP1 nuclear receptor interacting protein 1
NUSAP1 nucleolar and spindle associated protein 1
OXTR oxytocin receptor
PCGF2 polycomb group ring finger 2
PLAC8 placenta-specific 8
PLAT plasminogen activator, tissue
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PON2 paraoxonase 2
PPARG peroxisome proliferator-activated receptor gamma
PRSS23 protease, serine, 23
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SLIRP SRA stem-loop interacting RNA binding protein
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRY2 sprouty homolog 2 (Drosophila)
SRPX sushi-repeat containing protein, X-linked
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNC tenascin C
UPK1B uroplakin 1B
VCAN versican