BRD-K78062244_STOCK1N-27488_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

135 genes differentially expressed following the BRD-K78062244_STOCK1N-27488_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD3 abhydrolase domain containing 3
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
AQP3 aquaporin 3 (Gill blood group)
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BMP2 bone morphogenetic protein 2
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C10ORF10 chromosome 10 open reading frame 10
CD163 CD163 molecule
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLIC2 chloride intracellular channel 2
COL9A2 collagen, type IX, alpha 2
CSRP1 cysteine and glycine-rich protein 1
CTSZ cathepsin Z
CXCL2 chemokine (C-X-C motif) ligand 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNASE1L1 deoxyribonuclease I-like 1
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
ENO2 enolase 2 (gamma, neuronal)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM69A family with sequence similarity 69, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGL2 fibrinogen-like 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FTH1 ferritin, heavy polypeptide 1
GCLM glutamate-cysteine ligase, modifier subunit
GPNMB glycoprotein (transmembrane) nmb
HBB hemoglobin, beta
HCAR3 hydroxycarboxylic acid receptor 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IFI27 interferon, alpha-inducible protein 27
INHBA inhibin, beta A
INSR insulin receptor
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLHL24 kelch-like family member 24
LST1 leukocyte specific transcript 1
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MFAP5 microfibrillar associated protein 5
MLF1 myeloid leukemia factor 1
MSLN mesothelin
MSX1 msh homeobox 1
MXI1 MAX interactor 1, dimerization protein
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NKX3-1 NK3 homeobox 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RGCC regulator of cell cycle
RGS10 regulator of G-protein signaling 10
RTN1 reticulon 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SERINC5 serine incorporator 5
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFRP4 secreted frizzled-related protein 4
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNNT1 troponin T type 1 (skeletal, slow)
TSC22D3 TSC22 domain family, member 3
VEGFA vascular endothelial growth factor A
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AGR2 anterior gradient 2
AIM1 absent in melanoma 1
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARMCX2 armadillo repeat containing, X-linked 2
BZW2 basic leucine zipper and W2 domains 2
CADPS2 Ca++-dependent secretion activator 2
CD59 CD59 molecule, complement regulatory protein
CFI complement factor I
CPD carboxypeptidase D
CTSC cathepsin C
FABP4 fatty acid binding protein 4, adipocyte
FABP7 fatty acid binding protein 7, brain
FAM63A family with sequence similarity 63, member A
G0S2 G0/G1 switch 2
GGCT gamma-glutamylcyclotransferase
GSTA4 glutathione S-transferase alpha 4
HES1 hes family bHLH transcription factor 1
HOXC6 homeobox C6
IGFBP4 insulin-like growth factor binding protein 4
JADE2 jade family PHD finger 2
KIF20A kinesin family member 20A
LAMB1 laminin, beta 1
LGALS1 lectin, galactoside-binding, soluble, 1
MET MET proto-oncogene, receptor tyrosine kinase
MGP matrix Gla protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIB nuclear factor I/B
NNMT nicotinamide N-methyltransferase
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLAT plasminogen activator, tissue
PLK1 polo-like kinase 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PRSS3 protease, serine, 3
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS2 regulator of G-protein signaling 2
RHOBTB3 Rho-related BTB domain containing 3
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TNC tenascin C
TPBG trophoblast glycoprotein
TSPAN13 tetraspanin 13
ZWILCH zwilch kinetochore protein