BRD-K78062244_STOCK1N-27488_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

112 genes differentially expressed following the BRD-K78062244_STOCK1N-27488_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADIRF adipogenesis regulatory factor
AEBP1 AE binding protein 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
APOD apolipoprotein D
AQP1 aquaporin 1 (Colton blood group)
ATF3 activating transcription factor 3
C1QB complement component 1, q subcomponent, B chain
CA4 carbonic anhydrase IV
CADM1 cell adhesion molecule 1
CAV1 caveolin 1, caveolae protein, 22kDa
CD24 CD24 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CFD complement factor D (adipsin)
CLU clusterin
CPE carboxypeptidase E
CXCL9 chemokine (C-X-C motif) ligand 9
DHRS2 dehydrogenase/reductase (SDR family) member 2
EFHD1 EF-hand domain family, member D1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EXPH5 exophilin 5
FXYD6 FXYD domain containing ion transport regulator 6
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GBP2 guanylate binding protein 2, interferon-inducible
GLUL glutamate-ammonia ligase
GPM6B glycoprotein M6B
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HK1 hexokinase 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HTRA1 HtrA serine peptidase 1
IGFBP5 insulin-like growth factor binding protein 5
INSR insulin receptor
JUN jun proto-oncogene
KLHL21 kelch-like family member 21
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LMO3 LIM domain only 3 (rhombotin-like 2)
MFAP2 microfibrillar-associated protein 2
MT1X metallothionein 1X
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM1 olfactomedin 1
PLAU plasminogen activator, urokinase
PPAP2B phosphatidic acid phosphatase type 2B
PRKX protein kinase, X-linked
PTN pleiotrophin
RGCC regulator of cell cycle
S100A14 S100 calcium binding protein A14
SCGB2A1 secretoglobin, family 2A, member 1
SFN stratifin
SPARCL1 SPARC-like 1 (hevin)
STC1 stanniocalcin 1
STC2 stanniocalcin 2
TCF4 transcription factor 4
TIMP3 TIMP metallopeptidase inhibitor 3
TNIP1 TNFAIP3 interacting protein 1
TSKU tsukushi, small leucine rich proteoglycan

decreased expression

Symbol Name
ACSL5 acyl-CoA synthetase long-chain family member 5
ACTN1 actinin, alpha 1
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
BMI1 BMI1 proto-oncogene, polycomb ring finger
BST2 bone marrow stromal cell antigen 2
C8ORF4 chromosome 8 open reading frame 4
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCND1 cyclin D1
CDC25A cell division cycle 25A
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
CTSH cathepsin H
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
DUSP6 dual specificity phosphatase 6
ECI2 enoyl-CoA delta isomerase 2
F12 coagulation factor XII (Hageman factor)
FGA fibrinogen alpha chain
FGB fibrinogen beta chain
FXYD2 FXYD domain containing ion transport regulator 2
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
INPP1 inositol polyphosphate-1-phosphatase
ITGA6 integrin, alpha 6
LAMC1 laminin, gamma 1 (formerly LAMB2)
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MMD monocyte to macrophage differentiation-associated
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NNMT nicotinamide N-methyltransferase
PLAC8 placenta-specific 8
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PON2 paraoxonase 2
PPIF peptidylprolyl isomerase F
PRAME preferentially expressed antigen in melanoma
PRR7 proline rich 7 (synaptic)
PSPH phosphoserine phosphatase
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SRSF6 serine/arginine-rich splicing factor 6
TLE4 transducin-like enhancer of split 4
TMC5 transmembrane channel-like 5
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOX3 TOX high mobility group box family member 3