BRD-K78062244_STOCK1N-27488_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

167 genes differentially expressed following the BRD-K78062244_STOCK1N-27488_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACAA2 acetyl-CoA acyltransferase 2
ACKR3 atypical chemokine receptor 3
ADGRF5 adhesion G protein-coupled receptor F5
ADM adrenomedullin
AREG amphiregulin
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX2 armadillo repeat containing, X-linked 2
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BLNK B-cell linker
BLVRB biliverdin reductase B
BMP2 bone morphogenetic protein 2
BTG2 BTG family, member 2
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CCNG2 cyclin G2
CD163 CD163 molecule
CD24 CD24 molecule
CD2AP CD2-associated protein
CD40 CD40 molecule, TNF receptor superfamily member 5
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHN2 chimerin 2
CLIC5 chloride intracellular channel 5
COL4A1 collagen, type IV, alpha 1
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL2 chemokine (C-X-C motif) ligand 2
DENND1B DENN/MADD domain containing 1B
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLK1 delta-like 1 homolog (Drosophila)
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
ECM1 extracellular matrix protein 1
EMP1 epithelial membrane protein 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPAS1 endothelial PAS domain protein 1
FOXO3 forkhead box O3
FZD10 frizzled class receptor 10
GDF15 growth differentiation factor 15
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GRB7 growth factor receptor-bound protein 7
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBP1 HMG-box transcription factor 1
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IGF1R insulin-like growth factor 1 receptor
IGL immunoglobulin lambda locus
IL6 interleukin 6
INSIG1 insulin induced gene 1
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
KLHL24 kelch-like family member 24
MAN1A1 mannosidase, alpha, class 1A, member 1
MAN2A1 mannosidase, alpha, class 2A, member 1
MAP7 microtubule-associated protein 7
MDK midkine (neurite growth-promoting factor 2)
MME membrane metallo-endopeptidase
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1HL1 metallothionein 1H-like 1
MYO1D myosin ID
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPIPB3 nuclear pore complex interacting protein family, member B3
NPTX2 neuronal pentraxin II
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
OSBPL10 oxysterol binding protein-like 10
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PLIN2 perilipin 2
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRO protein tyrosine phosphatase, receptor type, O
PXDN peroxidasin
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RGCC regulator of cell cycle
RGS10 regulator of G-protein signaling 10
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SCG5 secretogranin V
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SIK1 salt-inducible kinase 1
SLC16A6 solute carrier family 16, member 6
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THBS1 thrombospondin 1
TMEM30B transmembrane protein 30B
TMSB15A thymosin beta 15a
TP53I3 tumor protein p53 inducible protein 3
UBE2B ubiquitin-conjugating enzyme E2B
UGDH UDP-glucose 6-dehydrogenase
VEGFA vascular endothelial growth factor A
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
B3GNT1
BCLAF1 BCL2-associated transcription factor 1
CAPRIN1 cell cycle associated protein 1
CCDC86 coiled-coil domain containing 86
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN3 cyclin-dependent kinase inhibitor 3
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
CTSH cathepsin H
DCPS decapping enzyme, scavenger
DPH2 DPH2 homolog (S. cerevisiae)
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
EMP3 epithelial membrane protein 3
FBLN1 fibulin 1
GRWD1 glutamate-rich WD repeat containing 1
HEXIM1 hexamethylene bis-acetamide inducible 1
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
KCTD12 potassium channel tetramerization domain containing 12
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KYNU kynureninase
LAMB1 laminin, beta 1
LAPTM4B lysosomal protein transmembrane 4 beta
LOXL1 lysyl oxidase-like 1
LRRC59 leucine rich repeat containing 59
LTF lactotransferrin
MINA MYC induced nuclear antigen
MLEC malectin
NOP16 NOP16 nucleolar protein
PEBP1 phosphatidylethanolamine binding protein 1
PIP prolactin-induced protein
PLK1 polo-like kinase 1
PRKCA protein kinase C, alpha
PRKCH protein kinase C, eta
PRMT1 protein arginine methyltransferase 1
PSAT1 phosphoserine aminotransferase 1
QPCT glutaminyl-peptide cyclotransferase
RRP1B ribosomal RNA processing 1B
S100A10 S100 calcium binding protein A10
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6
SLIT2 slit homolog 2 (Drosophila)
SORD sorbitol dehydrogenase
SPINK1 serine peptidase inhibitor, Kazal type 1
SQLE squalene epoxidase
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STEAP1 six transmembrane epithelial antigen of the prostate 1
TACC3 transforming, acidic coiled-coil containing protein 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGM2 transglutaminase 2
TLR4 toll-like receptor 4
TPX2 TPX2, microtubule-associated
UBE2S ubiquitin-conjugating enzyme E2S
VCAN versican
WBSCR22 Williams Beuren syndrome chromosome region 22
ZWILCH zwilch kinetochore protein