BRD-K78062244_STOCK1N-27488_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

213 genes differentially expressed following the BRD-K78062244_STOCK1N-27488_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAA2 acetyl-CoA acyltransferase 2
ADGRL4 adhesion G protein-coupled receptor L4
ADM adrenomedullin
AHCYL2 adenosylhomocysteinase-like 2
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
ALB albumin
ANK2 ankyrin 2, neuronal
ARMCX1 armadillo repeat containing, X-linked 1
ASRGL1 asparaginase like 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CA2 carbonic anhydrase II
CBR3 carbonyl reductase 3
CCND2 cyclin D2
CD93 CD93 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDH3 cadherin 3, type 1, P-cadherin (placental)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC2B C-type lectin domain family 2, member B
COL8A2 collagen, type VIII, alpha 2
CPQ carboxypeptidase Q
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CSRNP2 cysteine-serine-rich nuclear protein 2
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYB5R2 cytochrome b5 reductase 2
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DOK5 docking protein 5
DSP desmoplakin
DUSP6 dual specificity phosphatase 6
EFHD1 EF-hand domain family, member D1
EFS embryonal Fyn-associated substrate
EMP1 epithelial membrane protein 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPAS1 endothelial PAS domain protein 1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FAM129A family with sequence similarity 129, member A
FCGBP Fc fragment of IgG binding protein
GADD45B growth arrest and DNA-damage-inducible, beta
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GCLM glutamate-cysteine ligase, modifier subunit
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
HMOX1 heme oxygenase 1
HOMER3 homer scaffolding protein 3
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IFI16 interferon, gamma-inducible protein 16
IGFBP5 insulin-like growth factor binding protein 5
INSR insulin receptor
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KRT19 keratin 19, type I
KRT6B keratin 6B, type II
LAMA4 laminin, alpha 4
LGMN legumain
LOC100505650 uncharacterized LOC100505650
LXN latexin
LY96 lymphocyte antigen 96
LYN LYN proto-oncogene, Src family tyrosine kinase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MCL1 myeloid cell leukemia 1
MDFIC MyoD family inhibitor domain containing
MFAP5 microfibrillar associated protein 5
MMP3 matrix metallopeptidase 3
MSN moesin
MT1E metallothionein 1E
MTMR11 myotubularin related protein 11
NOX4 NADPH oxidase 4
NQO1 NAD(P)H dehydrogenase, quinone 1
NRCAM neuronal cell adhesion molecule
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCSK1 proprotein convertase subtilisin/kexin type 1
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDE4B phosphodiesterase 4B, cAMP-specific
PEG3 paternally expressed 3
PLIN2 perilipin 2
POSTN periostin, osteoblast specific factor
PPAP2B phosphatidic acid phosphatase type 2B
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTHLH parathyroid hormone-like hormone
PTPRD protein tyrosine phosphatase, receptor type, D
PTPRE protein tyrosine phosphatase, receptor type, E
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PXDN peroxidasin
RAB27A RAB27A, member RAS oncogene family
RAP2B RAP2B, member of RAS oncogene family
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A6 S100 calcium binding protein A6
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD5 stearoyl-CoA desaturase 5
SCG5 secretogranin V
SCGB2A2 secretoglobin, family 2A, member 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFRP4 secreted frizzled-related protein 4
SGK1 serum/glucocorticoid regulated kinase 1
SLC35G2 solute carrier family 35, member G2
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOCS2 suppressor of cytokine signaling 2
STC1 stanniocalcin 1
STC2 stanniocalcin 2
STX3 syntaxin 3
SULF1 sulfatase 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
TCEAL2 transcription elongation factor A (SII)-like 2
TF transferrin
THBD thrombomodulin
THBS1 thrombospondin 1
TPBG trophoblast glycoprotein
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIB2 tribbles pseudokinase 2
TRPS1 trichorhinophalangeal syndrome I
TULP3 tubby like protein 3
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VLDLR very low density lipoprotein receptor
WSCD1 WSC domain containing 1

decreased expression

Symbol Name
ACACA acetyl-CoA carboxylase alpha
ACOT7 acyl-CoA thioesterase 7
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA3 annexin A3
BAD BCL2-associated agonist of cell death
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC2 baculoviral IAP repeat containing 2
BST2 bone marrow stromal cell antigen 2
C9ORF16 chromosome 9 open reading frame 16
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CD24 CD24 molecule
CD47 CD47 molecule
CDC42 cell division cycle 42
CETN2 centrin, EF-hand protein, 2
CHSY1 chondroitin sulfate synthase 1
CMC2 C-x(9)-C motif containing 2
CTPS1 CTP synthase 1
CTSH cathepsin H
DCXR dicarbonyl/L-xylulose reductase
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial
FADS1 fatty acid desaturase 1
FASN fatty acid synthase
FBLN1 fibulin 1
GATA2 GATA binding protein 2
GRB14 growth factor receptor-bound protein 14
GRSF1 G-rich RNA sequence binding factor 1
GRWD1 glutamate-rich WD repeat containing 1
HADH hydroxyacyl-CoA dehydrogenase
HPRT1 hypoxanthine phosphoribosyltransferase 1
IFI6 interferon, alpha-inducible protein 6
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
LAGE3 L antigen family, member 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LUC7L3 LUC7-like 3 (S. cerevisiae)
LY6E lymphocyte antigen 6 complex, locus E
LYPLA1 lysophospholipase I
MAGED1 melanoma antigen family D1
MRPS16 mitochondrial ribosomal protein S16
MSMB microseminoprotein, beta-
MTA1 metastasis associated 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH10 myosin, heavy chain 10, non-muscle
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NME4 NME/NM23 nucleoside diphosphate kinase 4
NPY neuropeptide Y
NUTF2 nuclear transport factor 2
OXCT1 3-oxoacid CoA transferase 1
PCNA proliferating cell nuclear antigen
PDGFC platelet derived growth factor C
PRKCZ protein kinase C, zeta
PRMT1 protein arginine methyltransferase 1
PRPF4 pre-mRNA processing factor 4
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPN3 protein tyrosine phosphatase, non-receptor type 3
RAB4A RAB4A, member RAS oncogene family
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERF2 small EDRK-rich factor 2
SLC35F2 solute carrier family 35, member F2
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SMS spermine synthase
SORD sorbitol dehydrogenase
SOX9 SRY (sex determining region Y)-box 9
SREBF1 sterol regulatory element binding transcription factor 1
ST7 suppression of tumorigenicity 7
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TARBP1 TAR (HIV-1) RNA binding protein 1
TECR trans-2,3-enoyl-CoA reductase
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TRIM14 tripartite motif containing 14
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X
WDR61 WD repeat domain 61
YME1L1 YME1-like 1 ATPase
ZBTB18 zinc finger and BTB domain containing 18