BRD-K78122587_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

60 genes differentially expressed following the BRD-K78122587_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG1 adhesion G protein-coupled receptor G1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
BHLHE41 basic helix-loop-helix family, member e41
BTG2 BTG family, member 2
CCL20 chemokine (C-C motif) ligand 20
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COLEC12 collectin sub-family member 12
DDIT4 DNA-damage-inducible transcript 4
DLK1 delta-like 1 homolog (Drosophila)
DOK5 docking protein 5
DUSP4 dual specificity phosphatase 4
ETV1 ets variant 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
H1F0 H1 histone family, member 0
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IGHM immunoglobulin heavy constant mu
IGLJ3 immunoglobulin lambda joining 3
IGLV3-19 immunoglobulin lambda variable 3-19
INSIG1 insulin induced gene 1
KRT15 keratin 15, type I
LDLR low density lipoprotein receptor
MB myoglobin
MSMO1 methylsterol monooxygenase 1
NFIB nuclear factor I/B
NUPR1 nuclear protein, transcriptional regulator, 1
PDGFRL platelet-derived growth factor receptor-like
PEG3 paternally expressed 3
PHGDH phosphoglycerate dehydrogenase
PTN pleiotrophin
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SFN stratifin
SHB Src homology 2 domain containing adaptor protein B
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQLE squalene epoxidase
SQSTM1 sequestosome 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
CCND1 cyclin D1
CD59 CD59 molecule, complement regulatory protein
CIAPIN1 cytokine induced apoptosis inhibitor 1
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
FGFR3 fibroblast growth factor receptor 3
GJA1 gap junction protein, alpha 1, 43kDa
GPATCH8 G patch domain containing 8
IGFBP7 insulin-like growth factor binding protein 7
LTF lactotransferrin
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
PODXL podocalyxin-like
PRSS23 protease, serine, 23
SRSF6 serine/arginine-rich splicing factor 6
TUBB2A tubulin, beta 2A class IIa