BRD-K78167523_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

81 genes differentially expressed following the BRD-K78167523_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTC1 actin, alpha, cardiac muscle 1
ATP11B ATPase, class VI, type 11B
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLTB clathrin, light chain B
DMD dystrophin
ENO2 enolase 2 (gamma, neuronal)
F3 coagulation factor III (thromboplastin, tissue factor)
FBLN1 fibulin 1
IFI16 interferon, gamma-inducible protein 16
IFI6 interferon, alpha-inducible protein 6
KDM5D lysine (K)-specific demethylase 5D
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
LYN LYN proto-oncogene, Src family tyrosine kinase
MBP myelin basic protein
MTCL1 microtubule crosslinking factor 1
NES nestin
NR1H2 nuclear receptor subfamily 1, group H, member 2
NRIP1 nuclear receptor interacting protein 1
P3H2 prolyl 3-hydroxylase 2
PKP1 plakophilin 1
PLAT plasminogen activator, tissue
PRNP prion protein
PTN pleiotrophin
RCAN1 regulator of calcineurin 1
RXRA retinoid X receptor, alpha
SCD5 stearoyl-CoA desaturase 5
SCGB1D2 secretoglobin, family 1D, member 2
SPON2 spondin 2, extracellular matrix protein
TMEM158 transmembrane protein 158 (gene/pseudogene)
TXNIP thioredoxin interacting protein

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
ALDOA aldolase A, fructose-bisphosphate
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
ATM ATM serine/threonine kinase
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
CBR3 carbonyl reductase 3
CD93 CD93 molecule
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CXCL8 chemokine (C-X-C motif) ligand 8
CYTL1 cytokine-like 1
EIF5A eukaryotic translation initiation factor 5A
EIF5B eukaryotic translation initiation factor 5B
ESR1 estrogen receptor 1
FAR2 fatty acyl CoA reductase 2
FGF13 fibroblast growth factor 13
GMDS GDP-mannose 4,6-dehydratase
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IL13RA2 interleukin 13 receptor, alpha 2
LAMP5 lysosomal-associated membrane protein family, member 5
LMO2 LIM domain only 2 (rhombotin-like 1)
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LYZ lysozyme
MPO myeloperoxidase
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MYO1C myosin IC
NFIB nuclear factor I/B
NPTX2 neuronal pentraxin II
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PROM1 prominin 1
PTPRO protein tyrosine phosphatase, receptor type, O
RPL27A ribosomal protein L27a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
STARD7 StAR-related lipid transfer (START) domain containing 7
STOM stomatin
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TRIM33 tripartite motif containing 33
TSPYL5 TSPY-like 5
TXNDC9 thioredoxin domain containing 9