BRD-K78373679_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

76 genes differentially expressed following the BRD-K78373679_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
CBS cystathionine-beta-synthase
CD163 CD163 molecule
CD9 CD9 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLIC4 chloride intracellular channel 4
CST3 cystatin C
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
EMP1 epithelial membrane protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM129A family with sequence similarity 129, member A
GCH1 GTP cyclohydrolase 1
GLUL glutamate-ammonia ligase
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOA monoamine oxidase A
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1M metallothionein 1M
MYC v-myc avian myelocytomatosis viral oncogene homolog
NRGN neurogranin (protein kinase C substrate, RC3)
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PRUNE2 prune homolog 2 (Drosophila)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
SCG2 secretogranin II
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
STC2 stanniocalcin 2
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ACP5 acid phosphatase 5, tartrate resistant
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
BASP1 brain abundant, membrane attached signal protein 1
BLNK B-cell linker
BTK Bruton agammaglobulinemia tyrosine kinase
CD24 CD24 molecule
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
FLRT3 fibronectin leucine rich transmembrane protein 3
FZD7 frizzled class receptor 7
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
KRT18 keratin 18, type I
MGLL monoglyceride lipase
NRIP1 nuclear receptor interacting protein 1
PDHX pyruvate dehydrogenase complex, component X
PHACTR2 phosphatase and actin regulator 2
RPS11 ribosomal protein S11
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
STK17A serine/threonine kinase 17a
STOM stomatin
TFPI2 tissue factor pathway inhibitor 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TPM1 tropomyosin 1 (alpha)
TRIP6 thyroid hormone receptor interactor 6
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
WWTR1 WW domain containing transcription regulator 1