BRD-K78385490_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

137 genes differentially expressed following the BRD-K78385490_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
ADM adrenomedullin
AEBP1 AE binding protein 1
ALDOC aldolase C, fructose-bisphosphate
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG2 BTG family, member 2
CADM1 cell adhesion molecule 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L2 chitinase 3-like 2
CHIC2 cysteine-rich hydrophobic domain 2
COL9A3 collagen, type IX, alpha 3
COMP cartilage oligomeric matrix protein
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
FOSB FBJ murine osteosarcoma viral oncogene homolog B
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GLRX glutaredoxin (thioltransferase)
GSE1 Gse1 coiled-coil protein
HBEGF heparin-binding EGF-like growth factor
HEPH hephaestin
HIST1H2BG histone cluster 1, H2bg
HK2 hexokinase 2
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IER2 immediate early response 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
LGALS8 lectin, galactoside-binding, soluble, 8
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MT1M metallothionein 1M
NAMPT nicotinamide phosphoribosyltransferase
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRN1 neuritin 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PDGFA platelet-derived growth factor alpha polypeptide
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGK1 phosphoglycerate kinase 1
PLAU plasminogen activator, urokinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RAB20 RAB20, member RAS oncogene family
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RNMT RNA (guanine-7-) methyltransferase
SEPP1 selenoprotein P, plasma, 1
SERTAD2 SERTA domain containing 2
SFN stratifin
SIK1 salt-inducible kinase 1
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
STAR steroidogenic acute regulatory protein
STC1 stanniocalcin 1
STC2 stanniocalcin 2
TFF3 trefoil factor 3 (intestinal)
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNIP1 TNFAIP3 interacting protein 1
TP53 tumor protein p53
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
WISP2 WNT1 inducible signaling pathway protein 2
XBP1 X-box binding protein 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AHR aryl hydrocarbon receptor
AURKA aurora kinase A
CCNA2 cyclin A2
CCNF cyclin F
CCR7 chemokine (C-C motif) receptor 7
CD200 CD200 molecule
CDCA4 cell division cycle associated 4
COL3A1 collagen, type III, alpha 1
DEFB1 defensin, beta 1
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
FABP4 fatty acid binding protein 4, adipocyte
FBLN1 fibulin 1
FZD7 frizzled class receptor 7
GMNN geminin, DNA replication inhibitor
GNAS GNAS complex locus
HHEX hematopoietically expressed homeobox
HMGA2 high mobility group AT-hook 2
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFITM3 interferon induced transmembrane protein 3
IL27RA interleukin 27 receptor, alpha
ITGB1BP1 integrin beta 1 binding protein 1
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LAPTM4B lysosomal protein transmembrane 4 beta
LBR lamin B receptor
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MEIS2 Meis homeobox 2
MMP7 matrix metallopeptidase 7
MRPS12 mitochondrial ribosomal protein S12
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NR2F6 nuclear receptor subfamily 2, group F, member 6
NRP1 neuropilin 1
NUP107 nucleoporin 107kDa
PCDH7 protocadherin 7
PEG10 paternally expressed 10
PLEKHA5 pleckstrin homology domain containing, family A member 5
PON2 paraoxonase 2
PPARG peroxisome proliferator-activated receptor gamma
PRPF4 pre-mRNA processing factor 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TMEM147 transmembrane protein 147
TMEM2 transmembrane protein 2
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
ZNF706 zinc finger protein 706