BRD-K79090631_CGP-60474_HME1_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

195 genes differentially expressed following the BRD-K79090631_CGP-60474_HME1_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACKR3 atypical chemokine receptor 3
ADD3 adducin 3 (gamma)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANKRD36B ankyrin repeat domain 36B
APCS amyloid P component, serum
AQP1 aquaporin 1 (Colton blood group)
ASRGL1 asparaginase like 1
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
C9ORF16 chromosome 9 open reading frame 16
CADM1 cell adhesion molecule 1
CCL8 chemokine (C-C motif) ligand 8
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD4 CD4 molecule
CD84 CD84 molecule
CECR1 cat eye syndrome chromosome region, candidate 1
CERS6 ceramide synthase 6
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLEC7A C-type lectin domain family 7, member A
CLU clusterin
CNOT4 CCR4-NOT transcription complex, subunit 4
COL3A1 collagen, type III, alpha 1
CRP C-reactive protein, pentraxin-related
CTSB cathepsin B
CTSV cathepsin V
CXCL10 chemokine (C-X-C motif) ligand 10
DMXL2 Dmx-like 2
E2F2 E2F transcription factor 2
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
EPHB2 EPH receptor B2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERAP1 endoplasmic reticulum aminopeptidase 1
ESR1 estrogen receptor 1
FGL2 fibrinogen-like 2
FRY furry homolog (Drosophila)
GC group-specific component (vitamin D binding protein)
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GLT8D2 glycosyltransferase 8 domain containing 2
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GRB14 growth factor receptor-bound protein 14
GRN granulin
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HRG histidine-rich glycoprotein
IDS iduronate 2-sulfatase
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IL17RB interleukin 17 receptor B
IL1R1 interleukin 1 receptor, type I
IQCK IQ motif containing K
ITM2A integral membrane protein 2A
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KNG1 kininogen 1
KRAS Kirsten rat sarcoma viral oncogene homolog
LBP lipopolysaccharide binding protein
LDHB lactate dehydrogenase B
LEFTY1 left-right determination factor 1
LGALS3 lectin, galactoside-binding, soluble, 3
LOC100505650 uncharacterized LOC100505650
LRRC17 leucine rich repeat containing 17
LTBP1 latent transforming growth factor beta binding protein 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MATN2 matrilin 2
MEF2C myocyte enhancer factor 2C
MEIS1 Meis homeobox 1
METTL7A methyltransferase like 7A
MFAP2 microfibrillar-associated protein 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MXI1 MAX interactor 1, dimerization protein
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NGRN neugrin, neurite outgrowth associated
NUP210 nucleoporin 210kDa
OVGP1 oviductal glycoprotein 1, 120kDa
PCBP2 poly(rC) binding protein 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDE1A phosphodiesterase 1A, calmodulin-dependent
PEX11A peroxisomal biogenesis factor 11 alpha
PLAGL1 pleiomorphic adenoma gene-like 1
PLBD1 phospholipase B domain containing 1
PLD3 phospholipase D family, member 3
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTCH1 patched 1
PTPRD protein tyrosine phosphatase, receptor type, D
PTPRO protein tyrosine phosphatase, receptor type, O
RBP1 retinol binding protein 1, cellular
RGS5 regulator of G-protein signaling 5
RSAD2 radical S-adenosyl methionine domain containing 2
SCD5 stearoyl-CoA desaturase 5
SCGB2A1 secretoglobin, family 2A, member 1
SEPP1 selenoprotein P, plasma, 1
SERINC5 serine incorporator 5
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP1 secreted frizzled-related protein 1
SFRP4 secreted frizzled-related protein 4
SH3BGRL SH3 domain binding glutamate-rich protein like
SH3GL3 SH3-domain GRB2-like 3
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SOD2 superoxide dismutase 2, mitochondrial
SOX17 SRY (sex determining region Y)-box 17
STC1 stanniocalcin 1
STMN2 stathmin 2
TCF4 transcription factor 4
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPD52L1 tumor protein D52-like 1
TSPAN7 tetraspanin 7
TUSC3 tumor suppressor candidate 3
TYROBP TYRO protein tyrosine kinase binding protein
VNN1 vanin 1
VTCN1 V-set domain containing T cell activation inhibitor 1
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ATMIN ATM interactor
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAG3 BCL2-associated athanogene 3
BLCAP bladder cancer associated protein
BUB3 BUB3 mitotic checkpoint protein
CAB39 calcium binding protein 39
CCNA2 cyclin A2
CDC20 cell division cycle 20
CDK1 cyclin-dependent kinase 1
CLTC clathrin, heavy chain (Hc)
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
EPHA2 EPH receptor A2
FABP7 fatty acid binding protein 7, brain
FCGBP Fc fragment of IgG binding protein
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GRWD1 glutamate-rich WD repeat containing 1
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA8 heat shock 70kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
INHBB inhibin, beta B
ITGA6 integrin, alpha 6
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT7 keratin 7, type II
LASP1 LIM and SH3 protein 1
LDLR low density lipoprotein receptor
MALL mal, T-cell differentiation protein-like
MCAM melanoma cell adhesion molecule
MKI67 marker of proliferation Ki-67
MYBPC1 myosin binding protein C, slow type
MYOF myoferlin
NNMT nicotinamide N-methyltransferase
PCNA proliferating cell nuclear antigen
PDGFA platelet-derived growth factor alpha polypeptide
PLK1 polo-like kinase 1
PMP22 peripheral myelin protein 22
PNP purine nucleoside phosphorylase
PTX3 pentraxin 3, long
PUF60 poly-U binding splicing factor 60KDa
RPS4Y1 ribosomal protein S4, Y-linked 1
S100P S100 calcium binding protein P
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SOX9 SRY (sex determining region Y)-box 9
SPINK1 serine peptidase inhibitor, Kazal type 1
STIP1 stress-induced phosphoprotein 1
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TACC2 transforming, acidic coiled-coil containing protein 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TRAM2 translocation associated membrane protein 2
TRIM29 tripartite motif containing 29
TUBA4A tubulin, alpha 4a
TUBB3 tubulin, beta 3 class III
TUBB6 tubulin, beta 6 class V
TXLNA taxilin alpha
TYMS thymidylate synthetase
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2C ubiquitin-conjugating enzyme E2C
UPP1 uridine phosphorylase 1
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast)
ZDHHC6 zinc finger, DHHC-type containing 6
Funding