BRD-K79090631_CGP-60474_HS578T_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

238 genes differentially expressed following the BRD-K79090631_CGP-60474_HS578T_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AIDA axin interactor, dorsalization associated
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANGPTL2 angiopoietin-like 2
AOX1 aldehyde oxidase 1
AQP1 aquaporin 1 (Colton blood group)
ASPN asporin
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATHL1 ATH1, acid trehalase-like 1 (yeast)
BBX bobby sox homolog (Drosophila)
BLNK B-cell linker
C1R complement component 1, r subcomponent
C3 complement component 3
C7 complement component 7
CADM1 cell adhesion molecule 1
CAMP cathelicidin antimicrobial peptide
CCL20 chemokine (C-C motif) ligand 20
CCL5 chemokine (C-C motif) ligand 5
CCNA1 cyclin A1
CD2 CD2 molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CD4 CD4 molecule
CD84 CD84 molecule
CD9 CD9 molecule
CFB complement factor B
CFD complement factor D (adipsin)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLEC2B C-type lectin domain family 2, member B
CLEC7A C-type lectin domain family 7, member A
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COMP cartilage oligomeric matrix protein
CPE carboxypeptidase E
CSRP2 cysteine and glycine-rich protein 2
CSTA cystatin A (stefin A)
CTSV cathepsin V
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DPT dermatopontin
DSP desmoplakin
DUSP4 dual specificity phosphatase 4
ECM2 extracellular matrix protein 2, female organ and adipocyte specific
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB4 erb-b2 receptor tyrosine kinase 4
ESR1 estrogen receptor 1
EXPH5 exophilin 5
F11R F11 receptor
F13A1 coagulation factor XIII, A1 polypeptide
FBLN1 fibulin 1
FGFR3 fibroblast growth factor receptor 3
FGL2 fibrinogen-like 2
FHL1 four and a half LIM domains 1
FLRT2 fibronectin leucine rich transmembrane protein 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FPR3 formyl peptide receptor 3
FRY furry homolog (Drosophila)
FYB FYN binding protein
GADD45B growth arrest and DNA-damage-inducible, beta
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUK1 guanylate kinase 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HPSE heparanase
IDO1 indoleamine 2,3-dioxygenase 1
IDS iduronate 2-sulfatase
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL7R interleukin 7 receptor
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
ITM2C integral membrane protein 2C
KNG1 kininogen 1
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT19 keratin 19, type I
LCN2 lipocalin 2
LGMN legumain
LPPR4 lipid phosphate phosphatase-related protein type 4
LRRC15 leucine rich repeat containing 15
LSR lipolysis stimulated lipoprotein receptor
LTBP1 latent transforming growth factor beta binding protein 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MDFIC MyoD family inhibitor domain containing
MFAP5 microfibrillar associated protein 5
MMP9 matrix metallopeptidase 9
MOXD1 monooxygenase, DBH-like 1
MXRA5 matrix-remodelling associated 5
NMU neuromedin U
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PARP8 poly (ADP-ribose) polymerase family, member 8
PCSK6 proprotein convertase subtilisin/kexin type 6
PDE2A phosphodiesterase 2A, cGMP-stimulated
PERP PERP, TP53 apoptosis effector
PLAGL1 pleiomorphic adenoma gene-like 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLLP plasmolipin
PRAME preferentially expressed antigen in melanoma
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCQ protein kinase C, theta
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB25 RAB25, member RAS oncogene family
RABGAP1L RAB GTPase activating protein 1-like
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RNF130 ring finger protein 130
RPL31 ribosomal protein L31
RRAGD Ras-related GTP binding D
RSAD2 radical S-adenosyl methionine domain containing 2
S100A8 S100 calcium binding protein A8
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPP1 selenoprotein P, plasma, 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFRP4 secreted frizzled-related protein 4
SH3BGRL SH3 domain binding glutamate-rich protein like
SH3YL1 SH3 and SYLF domain containing 1
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SOD2 superoxide dismutase 2, mitochondrial
SPON1 spondin 1, extracellular matrix protein
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
SYNGR2 synaptogyrin 2
TFPI2 tissue factor pathway inhibitor 2
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TPD52 tumor protein D52
TPP1 tripeptidyl peptidase I
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
TUSC3 tumor suppressor candidate 3
TYROBP TYRO protein tyrosine kinase binding protein
VAV3 vav 3 guanine nucleotide exchange factor
VNN1 vanin 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WASF1 WAS protein family, member 1
XIST X inactive specific transcript (non-protein coding)
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
CALML5 calmodulin-like 5
CCNA2 cyclin A2
CDC20 cell division cycle 20
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CLTA clathrin, light chain A
COA3 cytochrome c oxidase assembly factor 3
CRK v-crk avian sarcoma virus CT10 oncogene homolog
DDIT4 DNA-damage-inducible transcript 4
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
EPS8 epidermal growth factor receptor pathway substrate 8
FABP7 fatty acid binding protein 7, brain
FOSL1 FOS-like antigen 1
FZD7 frizzled class receptor 7
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GLOD4 glyoxalase domain containing 4
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA8 heat shock 70kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
JCHAIN joining chain of multimeric IgA and IgM
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KEAP1 kelch-like ECH-associated protein 1
KIF20A kinesin family member 20A
KLHL41 kelch-like family member 41
KRT15 keratin 15, type I
LASP1 LIM and SH3 protein 1
LBR lamin B receptor
MAPRE1 microtubule-associated protein, RP/EB family, member 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MCAM melanoma cell adhesion molecule
MKNK2 MAP kinase interacting serine/threonine kinase 2
MMP7 matrix metallopeptidase 7
MPRIP myosin phosphatase Rho interacting protein
MYBPC1 myosin binding protein C, slow type
NEB nebulin
NES nestin
NUP62 nucleoporin 62kDa
PACSIN2 protein kinase C and casein kinase substrate in neurons 2
PCNA proliferating cell nuclear antigen
PEX11A peroxisomal biogenesis factor 11 alpha
PLIN2 perilipin 2
PLK1 polo-like kinase 1
POU2AF1 POU class 2 associating factor 1
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PTX3 pentraxin 3, long
PUF60 poly-U binding splicing factor 60KDa
PWP1 PWP1 homolog (S. cerevisiae)
RAE1 ribonucleic acid export 1
RIN2 Ras and Rab interactor 2
SCAND1 SCAN domain containing 1
SCGB2A2 secretoglobin, family 2A, member 2
SMAD3 SMAD family member 3
SMC4 structural maintenance of chromosomes 4
SOX9 SRY (sex determining region Y)-box 9
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRGN serglycin
SRSF1 serine/arginine-rich splicing factor 1
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TPX2 TPX2, microtubule-associated
TRAM2 translocation associated membrane protein 2
TRAPPC3 trafficking protein particle complex 3
TXLNA taxilin alpha
TXNRD1 thioredoxin reductase 1
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
USP22 ubiquitin specific peptidase 22
WSB1 WD repeat and SOCS box containing 1
XBP1 X-box binding protein 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZIC1 Zic family member 1
Funding