BRD-K79090631_CGP-60474_LNCAP_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

308 genes differentially expressed following the BRD-K79090631_CGP-60474_LNCAP_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACAA2 acetyl-CoA acyltransferase 2
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALDOC aldolase C, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANXA9 annexin A9
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
APOE apolipoprotein E
AQP1 aquaporin 1 (Colton blood group)
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
ATG12 autophagy related 12
ATP5E ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit
BCL2L1 BCL2-like 1
BEX1 brain expressed, X-linked 1
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
C5AR1 complement component 5a receptor 1
C6ORF62 chromosome 6 open reading frame 62
CAPZB capping protein (actin filament) muscle Z-line, beta
CCL4 chemokine (C-C motif) ligand 4
CD47 CD47 molecule
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFLAR CASP8 and FADD-like apoptosis regulator
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COCH cochlin
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
COL6A3 collagen, type VI, alpha 3
CPB1 carboxypeptidase B1 (tissue)
CPE carboxypeptidase E
CST3 cystatin C
CTSS cathepsin S
CTTN cortactin
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL8 chemokine (C-X-C motif) ligand 8
CYBB cytochrome b-245, beta polypeptide
CYBRD1 cytochrome b reductase 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYR61 cysteine-rich, angiogenic inducer, 61
DCTD dCMP deaminase
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DEFB1 defensin, beta 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DPYSL3 dihydropyrimidinase-like 3
DST dystonin
ECHDC2 enoyl CoA hydratase domain containing 2
EGR1 early growth response 1
EGR2 early growth response 2
EPCAM epithelial cell adhesion molecule
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ESR1 estrogen receptor 1
EZR ezrin
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM46A family with sequence similarity 46, member A
FAM50A family with sequence similarity 50, member A
FAM63A family with sequence similarity 63, member A
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FGFR3 fibroblast growth factor receptor 3
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
G0S2 G0/G1 switch 2
GDF15 growth differentiation factor 15
GDI1 GDP dissociation inhibitor 1
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GOLGA8B golgin A8 family, member B
GPM6A glycoprotein M6A
GPX3 glutathione peroxidase 3
GSTP1 glutathione S-transferase pi 1
GUK1 guanylate kinase 1
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HMGN5 high mobility group nucleosome binding domain 5
HP haptoglobin
HRSP12 heat-responsive protein 12
IDS iduronate 2-sulfatase
IFI27 interferon, alpha-inducible protein 27
IFI30 interferon, gamma-inducible protein 30
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IL2RB interleukin 2 receptor, beta
ISG15 ISG15 ubiquitin-like modifier
LAMP1 lysosomal-associated membrane protein 1
LAPTM5 lysosomal protein transmembrane 5
LARS leucyl-tRNA synthetase
LDHB lactate dehydrogenase B
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LTA4H leukotriene A4 hydrolase
LYN LYN proto-oncogene, Src family tyrosine kinase
MAN2B1 mannosidase, alpha, class 2B, member 1
MEF2C myocyte enhancer factor 2C
METRN meteorin, glial cell differentiation regulator
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MME membrane metallo-endopeptidase
MMP1 matrix metallopeptidase 1
MPP1 membrane protein, palmitoylated 1, 55kDa
MXRA7 matrix-remodelling associated 7
NPIPB3 nuclear pore complex interacting protein family, member B3
NR2F1 nuclear receptor subfamily 2, group F, member 1
NUCB1 nucleobindin 1
ORAI2 ORAI calcium release-activated calcium modulator 2
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDGFC platelet derived growth factor C
PDZD2 PDZ domain containing 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLBD1 phospholipase B domain containing 1
PLTP phospholipid transfer protein
PNMAL1 paraneoplastic Ma antigen family-like 1
PTN pleiotrophin
RAP2C RAP2C, member of RAS oncogene family
RBP1 retinol binding protein 1, cellular
RGCC regulator of cell cycle
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RIOK3 RIO kinase 3
S100A10 S100 calcium binding protein A10
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFTPC surfactant protein C
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SH3BGRL SH3 domain binding glutamate-rich protein like
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SNX10 sorting nexin 10
SPAG16 sperm associated antigen 16
SPON1 spondin 1, extracellular matrix protein
SYNGR3 synaptogyrin 3
TCF4 transcription factor 4
TGFB1 transforming growth factor, beta 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMBIM6 transmembrane BAX inhibitor motif containing 6
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPGS2 tubulin polyglutamylase complex subunit 2
TPM4 tropomyosin 4
TPP1 tripeptidyl peptidase I
TRIB2 tribbles pseudokinase 2
TTC3 tetratricopeptide repeat domain 3
TUSC3 tumor suppressor candidate 3
TYROBP TYRO protein tyrosine kinase binding protein
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WFDC2 WAP four-disulfide core domain 2
WIF1 WNT inhibitory factor 1
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZMAT3 zinc finger, matrin-type 3
ZNF264 zinc finger protein 264

decreased expression

Symbol Name
ACSL3 acyl-CoA synthetase long-chain family member 3
ACTA1 actin, alpha 1, skeletal muscle
ADGRG2 adhesion G protein-coupled receptor G2
ADGRG6 adhesion G protein-coupled receptor G6
ADRB2 adrenoceptor beta 2, surface
AKAP1 A kinase (PRKA) anchor protein 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALCAM activated leukocyte cell adhesion molecule
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AMD1 adenosylmethionine decarboxylase 1
ASS1 argininosuccinate synthase 1
ATMIN ATM interactor
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AUTS2 autism susceptibility candidate 2
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BRD3 bromodomain containing 3
C10ORF10 chromosome 10 open reading frame 10
C2CD5 C2 calcium-dependent domain containing 5
CA12 carbonic anhydrase XII
CANT1 calcium activated nucleotidase 1
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND1 cyclin D1
CD24 CD24 molecule
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHMP7 charged multivesicular body protein 7
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CKS2 CDC28 protein kinase regulatory subunit 2
CNOT7 CCR4-NOT transcription complex, subunit 7
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTBP2 C-terminal binding protein 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPH2 DPH2 homolog (S. cerevisiae)
DUOX2 dual oxidase 2
DUSP3 dual specificity phosphatase 3
DUSP5 dual specificity phosphatase 5
EIF4A3 eukaryotic translation initiation factor 4A3
ERBB2 erb-b2 receptor tyrosine kinase 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM57A family with sequence similarity 57, member A
FEN1 flap structure-specific endonuclease 1
FNDC3B fibronectin type III domain containing 3B
FOXO3 forkhead box O3
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
GCH1 GTP cyclohydrolase 1
GLOD4 glyoxalase domain containing 4
GPX2 glutathione peroxidase 2
H1F0 H1 histone family, member 0
H2AFX H2A histone family, member X
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA2 heat shock 70kDa protein 2
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IGF1R insulin-like growth factor 1 receptor
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ISG20 interferon stimulated exonuclease gene 20kDa
JCHAIN joining chain of multimeric IgA and IgM
KEAP1 kelch-like ECH-associated protein 1
KLHL9 kelch-like family member 9
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT7 keratin 7, type II
KRT81 keratin 81, type II
LBR lamin B receptor
LIMCH1 LIM and calponin homology domains 1
MAT2A methionine adenosyltransferase II, alpha
MB myoglobin
MCM10 minichromosome maintenance complex component 10
MED1 mediator complex subunit 1
MELK maternal embryonic leucine zipper kinase
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MPZL1 myelin protein zero-like 1
MREG melanoregulin
MTUS1 microtubule associated tumor suppressor 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYBPC1 myosin binding protein C, slow type
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NET1 neuroepithelial cell transforming 1
NFIB nuclear factor I/B
NKX3-1 NK3 homeobox 1
NOV nephroblastoma overexpressed
NRN1 neuritin 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PARP2 poly (ADP-ribose) polymerase 2
PCNA proliferating cell nuclear antigen
PHACTR2 phosphatase and actin regulator 2
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
PIP prolactin-induced protein
PNP purine nucleoside phosphorylase
PPAP2B phosphatidic acid phosphatase type 2B
PRKCD protein kinase C, delta
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PTPN12 protein tyrosine phosphatase, non-receptor type 12
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SCAND1 SCAN domain containing 1
SDC1 syndecan 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMAD1 SMAD family member 1
SORBS2 sorbin and SH3 domain containing 2
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TACC2 transforming, acidic coiled-coil containing protein 2
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TM4SF1 transmembrane 4 L six family member 1
TMEM97 transmembrane protein 97
TMPO thymopoietin
TNC tenascin C
TOB1 transducer of ERBB2, 1
TRIM16 tripartite motif containing 16
TRIM29 tripartite motif containing 29
TUBB4B tubulin, beta 4B class IVb
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2C ubiquitin-conjugating enzyme E2C
USP10 ubiquitin specific peptidase 10
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VGLL4 vestigial-like family member 4
VPS26A vacuolar protein sorting 26 homolog A (S. pombe)
XBP1 X-box binding protein 1
ZDHHC6 zinc finger, DHHC-type containing 6
ZFP36L2 ZFP36 ring finger protein-like 2
ZHX2 zinc fingers and homeoboxes 2
Funding