BRD-K79090631_CGP-60474_LNCAP_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

251 genes differentially expressed following the BRD-K79090631_CGP-60474_LNCAP_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
AAMDC adipogenesis associated, Mth938 domain containing
ACP1 acid phosphatase 1, soluble
ADD3 adducin 3 (gamma)
AHCY adenosylhomocysteinase
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALOX5 arachidonate 5-lipoxygenase
ANKRD36B ankyrin repeat domain 36B
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
APOE apolipoprotein E
AQP1 aquaporin 1 (Colton blood group)
AQP9 aquaporin 9
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
BSG basigin (Ok blood group)
C5AR1 complement component 5a receptor 1
CADM1 cell adhesion molecule 1
CCL4 chemokine (C-C motif) ligand 4
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CFLAR CASP8 and FADD-like apoptosis regulator
CKB creatine kinase, brain
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
COL6A3 collagen, type VI, alpha 3
CPB1 carboxypeptidase B1 (tissue)
CRABP2 cellular retinoic acid binding protein 2
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CTTN cortactin
CXCL10 chemokine (C-X-C motif) ligand 10
CYBRD1 cytochrome b reductase 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DPYSL3 dihydropyrimidinase-like 3
DST dystonin
ECM1 extracellular matrix protein 1
EGR1 early growth response 1
ENO2 enolase 2 (gamma, neuronal)
ENPEP glutamyl aminopeptidase (aminopeptidase A)
EPCAM epithelial cell adhesion molecule
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ESR1 estrogen receptor 1
FAXDC2 fatty acid hydroxylase domain containing 2
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FGFR3 fibroblast growth factor receptor 3
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
GFOD1 glucose-fructose oxidoreductase domain containing 1
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
GSTP1 glutathione S-transferase pi 1
GUK1 guanylate kinase 1
GUSBP3 glucuronidase, beta pseudogene 3
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-E major histocompatibility complex, class I, E
HLA-G major histocompatibility complex, class I, G
HMGN5 high mobility group nucleosome binding domain 5
HRSP12 heat-responsive protein 12
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDS iduronate 2-sulfatase
IFI27 interferon, alpha-inducible protein 27
IFI30 interferon, gamma-inducible protein 30
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IFITM3 interferon induced transmembrane protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
INHBA inhibin, beta A
ISG15 ISG15 ubiquitin-like modifier
JADE2 jade family PHD finger 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
LAMP3 lysosomal-associated membrane protein 3
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LOC100272216 uncharacterized LOC100272216
LRRC17 leucine rich repeat containing 17
LTA4H leukotriene A4 hydrolase
LYN LYN proto-oncogene, Src family tyrosine kinase
MAN1A1 mannosidase, alpha, class 1A, member 1
MDFIC MyoD family inhibitor domain containing
METRN meteorin, glial cell differentiation regulator
MMP1 matrix metallopeptidase 1
MMP19 matrix metallopeptidase 19
MMP9 matrix metallopeptidase 9
MPP1 membrane protein, palmitoylated 1, 55kDa
MSRB1 methionine sulfoxide reductase B1
MT1F metallothionein 1F
MX1 MX dynamin-like GTPase 1
MXRA7 matrix-remodelling associated 7
NPIPB3 nuclear pore complex interacting protein family, member B3
NQO2 NAD(P)H dehydrogenase, quinone 2
NR2F1 nuclear receptor subfamily 2, group F, member 1
NTAN1 N-terminal asparagine amidase
OSBPL10 oxysterol binding protein-like 10
PAM peptidylglycine alpha-amidating monooxygenase
PAWR PRKC, apoptosis, WT1, regulator
PLAGL1 pleiomorphic adenoma gene-like 1
PRSS21 protease, serine, 21 (testisin)
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTN pleiotrophin
RAP2C RAP2C, member of RAS oncogene family
RBP1 retinol binding protein 1, cellular
RGCC regulator of cell cycle
RSAD2 radical S-adenosyl methionine domain containing 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SMYD3 SET and MYND domain containing 3
SNX10 sorting nexin 10
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STC1 stanniocalcin 1
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TCL1A T-cell leukemia/lymphoma 1A
TGFBI transforming growth factor, beta-induced, 68kDa
THY1 Thy-1 cell surface antigen
TIMP1 TIMP metallopeptidase inhibitor 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMBIM6 transmembrane BAX inhibitor motif containing 6
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRIB2 tribbles pseudokinase 2
TUBB2B tubulin, beta 2B class IIb
TYROBP TYRO protein tyrosine kinase binding protein
VAMP7 vesicle-associated membrane protein 7
WIF1 WNT inhibitory factor 1

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ADGRG6 adhesion G protein-coupled receptor G6
ADRB2 adrenoceptor beta 2, surface
AKAP1 A kinase (PRKA) anchor protein 1
ALCAM activated leukocyte cell adhesion molecule
AMD1 adenosylmethionine decarboxylase 1
ARF6 ADP-ribosylation factor 6
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ATMIN ATM interactor
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
AUTS2 autism susceptibility candidate 2
B3GNT1
BAG3 BCL2-associated athanogene 3
CA12 carbonic anhydrase XII
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CANT1 calcium activated nucleotidase 1
CCNA2 cyclin A2
CCNB2 cyclin B2
CD164 CD164 molecule, sialomucin
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CKS2 CDC28 protein kinase regulatory subunit 2
CNOT7 CCR4-NOT transcription complex, subunit 7
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL5 chemokine (C-X-C motif) ligand 5
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DDIT4 DNA-damage-inducible transcript 4
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DEPDC1 DEP domain containing 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP7 dual specificity phosphatase 7
EIF4E eukaryotic translation initiation factor 4E
ERBB2 erb-b2 receptor tyrosine kinase 2
GAS1 growth arrest-specific 1
GATA2 GATA binding protein 2
GCH1 GTP cyclohydrolase 1
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GRB10 growth factor receptor-bound protein 10
GSPT2 G1 to S phase transition 2
H2AFX H2A histone family, member X
HMGB2 high mobility group box 2
HNRNPF heterogeneous nuclear ribonucleoprotein F
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
JCHAIN joining chain of multimeric IgA and IgM
KRT7 keratin 7, type II
LIMCH1 LIM and calponin homology domains 1
MAK16 MAK16 homolog (S. cerevisiae)
MAPK6 mitogen-activated protein kinase 6
MB myoglobin
MED1 mediator complex subunit 1
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MTUS1 microtubule associated tumor suppressor 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYBPC1 myosin binding protein C, slow type
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH10 myosin, heavy chain 10, non-muscle
NEK2 NIMA-related kinase 2
NET1 neuroepithelial cell transforming 1
NFIB nuclear factor I/B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGDN neuroguidin, EIF4E binding protein
NKX3-1 NK3 homeobox 1
NOP56 NOP56 ribonucleoprotein
NR2F6 nuclear receptor subfamily 2, group F, member 6
NUP62 nucleoporin 62kDa
NXT1 nuclear transport factor 2-like export factor 1
PCNA proliferating cell nuclear antigen
PLCB4 phospholipase C, beta 4
PLK1 polo-like kinase 1
PRPF4B pre-mRNA processing factor 4B
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RAB14 RAB14, member RAS oncogene family
RFK riboflavin kinase
RNPS1 RNA binding protein S1, serine-rich domain
RPL39L ribosomal protein L39-like
SCAND1 SCAN domain containing 1
SIK1 salt-inducible kinase 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SNAP25 synaptosomal-associated protein, 25kDa
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5)
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SOX4 SRY (sex determining region Y)-box 4
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TACC2 transforming, acidic coiled-coil containing protein 2
TFAM transcription factor A, mitochondrial
TMEM70 transmembrane protein 70
TMEM97 transmembrane protein 97
TMPO thymopoietin
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOB1 transducer of ERBB2, 1
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOX3 TOX high mobility group box family member 3
TSPYL1 TSPY-like 1
TXLNA taxilin alpha
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2C ubiquitin-conjugating enzyme E2C
USP22 ubiquitin specific peptidase 22
WDR82 WD repeat domain 82
XBP1 X-box binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZNF217 zinc finger protein 217
Funding