BRD-K79090631_CGP-60474_LNCAP_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

166 genes differentially expressed following the BRD-K79090631_CGP-60474_LNCAP_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANXA10 annexin A10
BCHE butyrylcholinesterase
CCL20 chemokine (C-C motif) ligand 20
CD36 CD36 molecule (thrombospondin receptor)
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CSRP1 cysteine and glycine-rich protein 1
CSTA cystatin A (stefin A)
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DOK5 docking protein 5
EYA1 EYA transcriptional coactivator and phosphatase 1
FAM171A1 family with sequence similarity 171, member A1
GPM6A glycoprotein M6A
HOXC10 homeobox C10
HOXC6 homeobox C6
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ITM2C integral membrane protein 2C
LAMP5 lysosomal-associated membrane protein family, member 5
MAB21L2 mab-21-like 2 (C. elegans)
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAOA monoamine oxidase A
MLF1 myeloid leukemia factor 1
MX2 MX dynamin-like GTPase 2
NTS neurotensin
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic)
PAM peptidylglycine alpha-amidating monooxygenase
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDE10A phosphodiesterase 10A
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCA protein kinase C, alpha
RAB31 RAB31, member RAS oncogene family
RBP1 retinol binding protein 1, cellular
RGS10 regulator of G-protein signaling 10
ROGDI rogdi homolog (Drosophila)
SCG5 secretogranin V
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SMYD3 SET and MYND domain containing 3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STAR steroidogenic acute regulatory protein
SYNM synemin, intermediate filament protein
SYT1 synaptotagmin I
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
THBS2 thrombospondin 2
THBS4 thrombospondin 4
TLR4 toll-like receptor 4
TMEM100 transmembrane protein 100
TMEM45A transmembrane protein 45A
TRIB2 tribbles pseudokinase 2
YBX1 Y box binding protein 1

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADM adrenomedullin
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADRB2 adrenoceptor beta 2, surface
AHNAK2 AHNAK nucleoprotein 2
AMOTL2 angiomotin like 2
APOLD1 apolipoprotein L domain containing 1
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BAG5 BCL2-associated athanogene 5
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
BCL10 B-cell CLL/lymphoma 10
BHLHE40 basic helix-loop-helix family, member e40
BTG1 B-cell translocation gene 1, anti-proliferative
CAV1 caveolin 1, caveolae protein, 22kDa
CBR3 carbonyl reductase 3
CCNF cyclin F
CCNG2 cyclin G2
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CKS2 CDC28 protein kinase regulatory subunit 2
COL15A1 collagen, type XV, alpha 1
CXCL9 chemokine (C-X-C motif) ligand 9
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP5 dual specificity phosphatase 5
EGFR epidermal growth factor receptor
EIF5 eukaryotic translation initiation factor 5
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FOSL1 FOS-like antigen 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HILPDA hypoxia inducible lipid droplet-associated
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER5 immediate early response 5
IGF1R insulin-like growth factor 1 receptor
JADE2 jade family PHD finger 2
KAT6A K(lysine) acetyltransferase 6A
KLF10 Kruppel-like factor 10
KLHL9 kelch-like family member 9
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK6 mitogen-activated protein kinase 6
MARCKS myristoylated alanine-rich protein kinase C substrate
MAT2A methionine adenosyltransferase II, alpha
MCL1 myeloid cell leukemia 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRIP1 nuclear receptor interacting protein 1
NRN1 neuritin 1
NUP62 nucleoporin 62kDa
PDZRN3 PDZ domain containing ring finger 3
PEG10 paternally expressed 10
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PLAGL2 pleiomorphic adenoma gene-like 2
PPAP2B phosphatidic acid phosphatase type 2B
PROM1 prominin 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAP2B RAP2B, member of RAS oncogene family
RBM15 RNA binding motif protein 15
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIK1 salt-inducible kinase 1
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMAD7 SMAD family member 7
SOX4 SRY (sex determining region Y)-box 4
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TBP TATA box binding protein
TBX3 T-box 3
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGFBR3 transforming growth factor, beta receptor III
TGIF1 TGFB-induced factor homeobox 1
TICAM1 toll-like receptor adaptor molecule 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM70 transmembrane protein 70
TMSB15A thymosin beta 15a
TOB2 transducer of ERBB2, 2
TPSB2 tryptase beta 2 (gene/pseudogene)
VEGFA vascular endothelial growth factor A
WEE1 WEE1 G2 checkpoint kinase
ZFAND5 zinc finger, AN1-type domain 5
ZFP36L2 ZFP36 ring finger protein-like 2
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF217 zinc finger protein 217
ZNF232 zinc finger protein 232
Funding