BRD-K79090631_CGP-60474_MCF7_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

110 genes differentially expressed following the BRD-K79090631_CGP-60474_MCF7_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRF5 adhesion G protein-coupled receptor F5
AGTR1 angiotensin II receptor, type 1
AMACR alpha-methylacyl-CoA racemase
ANOS1 anosmin 1
ANXA3 annexin A3
AOX1 aldehyde oxidase 1
CD320 CD320 molecule
CNN3 calponin 3, acidic
CXCL14 chemokine (C-X-C motif) ligand 14
EPCAM epithelial cell adhesion molecule
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
F13A1 coagulation factor XIII, A1 polypeptide
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GHR growth hormone receptor
GLRX glutaredoxin (thioltransferase)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPC3 glypican 3
H2AFY H2A histone family, member Y
IFI6 interferon, alpha-inducible protein 6
LGALS1 lectin, galactoside-binding, soluble, 1
LIMCH1 LIM and calponin homology domains 1
MAP2K5 mitogen-activated protein kinase kinase 5
MDFIC MyoD family inhibitor domain containing
MECOM MDS1 and EVI1 complex locus
MGLL monoglyceride lipase
NELL2 NEL-like 2 (chicken)
NES nestin
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PLAT plasminogen activator, tissue
PLS3 plastin 3
PRSS21 protease, serine, 21 (testisin)
PSD3 pleckstrin and Sec7 domain containing 3
PTPRK protein tyrosine phosphatase, receptor type, K
S100A9 S100 calcium binding protein A9
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SORD sorbitol dehydrogenase
SPINT2 serine peptidase inhibitor, Kunitz type, 2
STEAP1 six transmembrane epithelial antigen of the prostate 1
TARBP1 TAR (HIV-1) RNA binding protein 1
THBS1 thrombospondin 1
TSPAN8 tetraspanin 8
TXN thioredoxin
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

decreased expression

Symbol Name
ADM adrenomedullin
ADNP activity-dependent neuroprotector homeobox
ARID4B AT rich interactive domain 4B (RBP1-like)
ATF1 activating transcription factor 1
ATF3 activating transcription factor 3
AUTS2 autism susceptibility candidate 2
B3GNT1
BAMBI BMP and activin membrane-bound inhibitor
BHLHE40 basic helix-loop-helix family, member e40
CADM1 cell adhesion molecule 1
CD24 CD24 molecule
CDC25A cell division cycle 25A
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CEMIP cell migration inducing protein, hyaluronan binding
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
EED embryonic ectoderm development
EGR1 early growth response 1
EGR2 early growth response 2
ELF4 E74-like factor 4 (ets domain transcription factor)
FZD7 frizzled class receptor 7
HEXIM1 hexamethylene bis-acetamide inducible 1
HOXA1 homeobox A1
IER2 immediate early response 2
IER5 immediate early response 5
JADE2 jade family PHD finger 2
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KLF10 Kruppel-like factor 10
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MCL1 myeloid cell leukemia 1
MFAP5 microfibrillar associated protein 5
NCK1 NCK adaptor protein 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR2F6 nuclear receptor subfamily 2, group F, member 6
OSR2 odd-skipped related transciption factor 2
PER2 period circadian clock 2
PNN pinin, desmosome associated protein
PPP1R12A protein phosphatase 1, regulatory subunit 12A
RHOB ras homolog family member B
RPP38 ribonuclease P/MRP 38kDa subunit
SCGB2A1 secretoglobin, family 2A, member 1
SESN1 sestrin 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC38A1 solute carrier family 38, member 1
SOX4 SRY (sex determining region Y)-box 4
SPINK1 serine peptidase inhibitor, Kazal type 1
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGIF1 TGFB-induced factor homeobox 1
TLE4 transducin-like enhancer of split 4
TOB1 transducer of ERBB2, 1
TUFT1 tuftelin 1
USP1 ubiquitin specific peptidase 1
VEZF1 vascular endothelial zinc finger 1
WTAP Wilms tumor 1 associated protein
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2
ZFPM2 zinc finger protein, FOG family member 2
Funding