BRD-K79090631_CGP-60474_SKBR3_3_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

79 genes differentially expressed following the BRD-K79090631_CGP-60474_SKBR3_3_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
CASP2 caspase 2, apoptosis-related cysteine peptidase
CFB complement factor B
CHL1 cell adhesion molecule L1-like
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLDN10 claudin 10
COL15A1 collagen, type XV, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
COL6A3 collagen, type VI, alpha 3
CP ceruloplasmin (ferroxidase)
CST3 cystatin C
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
DDAH1 dimethylarginine dimethylaminohydrolase 1
ELOVL2 ELOVL fatty acid elongase 2
FAM134B family with sequence similarity 134, member B
GAS7 growth arrest-specific 7
GRB14 growth factor receptor-bound protein 14
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HOXC6 homeobox C6
IFI44 interferon-induced protein 44
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
MEF2C myocyte enhancer factor 2C
MYLK myosin light chain kinase
MYO5C myosin VC
NYNRIN NYN domain and retroviral integrase containing
PDZK1 PDZ domain containing 1
PECR peroxisomal trans-2-enoyl-CoA reductase
PLS3 plastin 3
PLSCR1 phospholipid scramblase 1
PRAME preferentially expressed antigen in melanoma
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SPON1 spondin 1, extracellular matrix protein
TNC tenascin C
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
ADM adrenomedullin
C6ORF62 chromosome 6 open reading frame 62
CD24 CD24 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CXCL14 chemokine (C-X-C motif) ligand 14
DEGS1 delta(4)-desaturase, sphingolipid 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
HES1 hes family bHLH transcription factor 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IGHM immunoglobulin heavy constant mu
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
JAG1 jagged 1
KANK1 KN motif and ankyrin repeat domains 1
KRT23 keratin 23, type I
LYPLA1 lysophospholipase I
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
RPP38 ribonuclease P/MRP 38kDa subunit
S100A9 S100 calcium binding protein A9
SDC1 syndecan 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLPI secretory leukocyte peptidase inhibitor
SST somatostatin
TES testin LIM domain protein
TRIM29 tripartite motif containing 29
TUBA4A tubulin, alpha 4a
ZFP36L2 ZFP36 ring finger protein-like 2
Funding