BRD-K79131428_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

109 genes differentially expressed following the BRD-K79131428_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACP5 acid phosphatase 5, tartrate resistant
ACPP acid phosphatase, prostate
ALOX5 arachidonate 5-lipoxygenase
APP amyloid beta (A4) precursor protein
AQP3 aquaporin 3 (Gill blood group)
ARG2 arginase 2
ARMCX1 armadillo repeat containing, X-linked 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
BLNK B-cell linker
CCND2 cyclin D2
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL1A2 collagen, type I, alpha 2
CREM cAMP responsive element modulator
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYTIP cytohesin 1 interacting protein
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EVI2B ecotropic viral integration site 2B
FAM129A family with sequence similarity 129, member A
FKBP11 FK506 binding protein 11, 19 kDa
FKBP14 FK506 binding protein 14, 22 kDa
GDF15 growth differentiation factor 15
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GLRX glutaredoxin (thioltransferase)
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA13 heat shock protein 70kDa family, member 13
HYOU1 hypoxia up-regulated 1
IL1R1 interleukin 1 receptor, type I
IL7R interleukin 7 receptor
INSIG1 insulin induced gene 1
KDM5D lysine (K)-specific demethylase 5D
KLRB1 killer cell lectin-like receptor subfamily B, member 1
KRT13 keratin 13, type I
LPAR6 lysophosphatidic acid receptor 6
LTB lymphotoxin beta (TNF superfamily, member 3)
LUM lumican
MACF1 microtubule-actin crosslinking factor 1
MMD monocyte to macrophage differentiation-associated
MSMO1 methylsterol monooxygenase 1
NEFL neurofilament, light polypeptide
NEU1 sialidase 1 (lysosomal sialidase)
NPTX2 neuronal pentraxin II
NUCB2 nucleobindin 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDZK1IP1 PDZK1 interacting protein 1
PID1 phosphotyrosine interaction domain containing 1
PPIB peptidylprolyl isomerase B (cyclophilin B)
PSPH phosphoserine phosphatase
RND3 Rho family GTPase 3
RNF167 ring finger protein 167
RPS4Y1 ribosomal protein S4, Y-linked 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SOAT1 sterol O-acyltransferase 1
SPP1 secreted phosphoprotein 1
SQLE squalene epoxidase
SSR1 signal sequence receptor, alpha
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TBX3 T-box 3
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM100 transmembrane protein 100
TMEM45A transmembrane protein 45A
VEGFA vascular endothelial growth factor A
VIM vimentin

decreased expression

Symbol Name
AHCYL1 adenosylhomocysteinase-like 1
AKR1C3 aldo-keto reductase family 1, member C3
AREG amphiregulin
ASCL1 achaete-scute family bHLH transcription factor 1
CCND1 cyclin D1
CDA cytidine deaminase
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COMP cartilage oligomeric matrix protein
CXCL9 chemokine (C-X-C motif) ligand 9
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
EGR3 early growth response 3
FERMT1 fermitin family member 1
FOSL1 FOS-like antigen 1
FST follistatin
GSE1 Gse1 coiled-coil protein
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
KRT19 keratin 19, type I
LAMC1 laminin, gamma 1 (formerly LAMB2)
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MTA1 metastasis associated 1
MYB v-myb avian myeloblastosis viral oncogene homolog
MYO6 myosin VI
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NFIB nuclear factor I/B
NPR3 natriuretic peptide receptor 3
PIP prolactin-induced protein
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
PRKCD protein kinase C, delta
SEPT11 septin 11
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF3 trefoil factor 3 (intestinal)
TRIM44 tripartite motif containing 44
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
UBA1 ubiquitin-like modifier activating enzyme 1