BRD-K79390395_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

70 genes differentially expressed following the BRD-K79390395_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD4 abhydrolase domain containing 4
AK4 adenylate kinase 4
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
CBR3 carbonyl reductase 3
COMP cartilage oligomeric matrix protein
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
FOSL1 FOS-like antigen 1
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GCLM glutamate-cysteine ligase, modifier subunit
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
INSIG1 insulin induced gene 1
KDM3A lysine (K)-specific demethylase 3A
LPL lipoprotein lipase
MCL1 myeloid cell leukemia 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MIR22HG MIR22 host gene
MSLN mesothelin
NPR3 natriuretic peptide receptor 3
OBSL1 obscurin-like 1
PIR pirin (iron-binding nuclear protein)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TXN thioredoxin
TXNRD1 thioredoxin reductase 1

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
C1QA complement component 1, q subcomponent, A chain
C7 complement component 7
CCND1 cyclin D1
CXCL9 chemokine (C-X-C motif) ligand 9
CYBA cytochrome b-245, alpha polypeptide
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DENND2D DENN/MADD domain containing 2D
DHRS3 dehydrogenase/reductase (SDR family) member 3
FBLN1 fibulin 1
FHL1 four and a half LIM domains 1
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HES1 hes family bHLH transcription factor 1
HOXA5 homeobox A5
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MEST mesoderm specific transcript
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
NKG7 natural killer cell granule protein 7
NR2F6 nuclear receptor subfamily 2, group F, member 6
PEG10 paternally expressed 10
PRKCD protein kinase C, delta
RGS5 regulator of G-protein signaling 5
RHOBTB3 Rho-related BTB domain containing 3
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SNX10 sorting nexin 10
SOX11 SRY (sex determining region Y)-box 11
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TESC tescalcin
TFF1 trefoil factor 1
TGM2 transglutaminase 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10