BRD-K80348542_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

220 genes differentially expressed following the BRD-K80348542_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ARHGAP29 Rho GTPase activating protein 29
ARID4B AT rich interactive domain 4B (RBP1-like)
ATF3 activating transcription factor 3
BEX1 brain expressed, X-linked 1
BHLHE41 basic helix-loop-helix family, member e41
BIK BCL2-interacting killer (apoptosis-inducing)
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCNL1 cyclin L1
CDK17 cyclin-dependent kinase 17
CDK7 cyclin-dependent kinase 7
CDKN2AIP CDKN2A interacting protein
CHIC2 cysteine-rich hydrophobic domain 2
CLK4 CDC-like kinase 4
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COG2 component of oligomeric golgi complex 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYLD cylindromatosis (turban tumor syndrome)
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DIEXF digestive organ expansion factor homolog (zebrafish)
DPH2 DPH2 homolog (S. cerevisiae)
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP14 dual specificity phosphatase 14
DUSP6 dual specificity phosphatase 6
EFNA1 ephrin-A1
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
ELF1 E74-like factor 1 (ets domain transcription factor)
FAM13A family with sequence similarity 13, member A
FAM179B family with sequence similarity 179, member B
FHL2 four and a half LIM domains 2
FNBP4 formin binding protein 4
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO1 forkhead box O1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA6 GATA binding protein 6
GEM GTP binding protein overexpressed in skeletal muscle
H2BFS H2B histone family, member S (pseudogene)
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BK histone cluster 1, H2bk
HIST1H4H histone cluster 1, H4h
IER2 immediate early response 2
IER3 immediate early response 3
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
ING3 inhibitor of growth family, member 3
INTS6 integrator complex subunit 6
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KLF6 Kruppel-like factor 6
KRT7 keratin 7, type II
LIF leukemia inhibitory factor
LIPG lipase, endothelial
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA12 melanoma antigen family A12
MCL1 myeloid cell leukemia 1
MRPS31 mitochondrial ribosomal protein S31
NEFL neurofilament, light polypeptide
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSPC1 paraspeckle component 1
PTBP2 polypyrimidine tract binding protein 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RBM34 RNA binding motif protein 34
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RLF rearranged L-myc fusion
RNMT RNA (guanine-7-) methyltransferase
RSRC2 arginine/serine-rich coiled-coil 2
SAMD4A sterile alpha motif domain containing 4A
SCYL3 SCY1-like 3 (S. cerevisiae)
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SMAD3 SMAD family member 3
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SOX9 SRY (sex determining region Y)-box 9
SRRM2 serine/arginine repetitive matrix 2
SRSF7 serine/arginine-rich splicing factor 7
STK38L serine/threonine kinase 38 like
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TBCE tubulin folding cofactor E
TFB2M transcription factor B2, mitochondrial
TFF3 trefoil factor 3 (intestinal)
THUMPD2 THUMP domain containing 2
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNIK TRAF2 and NCK interacting kinase
TNPO1 transportin 1
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae)
TSC22D2 TSC22 domain family, member 2
TUFT1 tuftelin 1
TXNL4B thioredoxin-like 4B
UBAP1 ubiquitin associated protein 1
UBAP2 ubiquitin associated protein 2
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VCPKMT valosin containing protein lysine (K) methyltransferase
XIST X inactive specific transcript (non-protein coding)
ZBTB10 zinc finger and BTB domain containing 10
ZCCHC8 zinc finger, CCHC domain containing 8
ZFP36 ZFP36 ring finger protein
ZNF24 zinc finger protein 24
ZNF274 zinc finger protein 274
ZNF432 zinc finger protein 432
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
B3GNT1
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
C6ORF62 chromosome 6 open reading frame 62
CALU calumenin
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV2 caveolin 2
CCNA2 cyclin A2
CCND1 cyclin D1
CCNF cyclin F
CD14 CD14 molecule
CLCA4 chloride channel accessory 4
COL1A2 collagen, type I, alpha 2
COL4A1 collagen, type IV, alpha 1
COL6A1 collagen, type VI, alpha 1
CPT1A carnitine palmitoyltransferase 1A (liver)
CTSZ cathepsin Z
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DBN1 drebrin 1
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPYSL2 dihydropyrimidinase-like 2
DUSP4 dual specificity phosphatase 4
ERBB3 erb-b2 receptor tyrosine kinase 3
FAM20B family with sequence similarity 20, member B
FAM57A family with sequence similarity 57, member A
FGFR3 fibroblast growth factor receptor 3
FSTL1 follistatin-like 1
FTH1 ferritin, heavy polypeptide 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GPNMB glycoprotein (transmembrane) nmb
GSTA1 glutathione S-transferase alpha 1
GSTP1 glutathione S-transferase pi 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGA2 high mobility group AT-hook 2
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDO1 indoleamine 2,3-dioxygenase 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
LAPTM4B lysosomal protein transmembrane 4 beta
LBR lamin B receptor
LPGAT1 lysophosphatidylglycerol acyltransferase 1
MAT2A methionine adenosyltransferase II, alpha
MEF2C myocyte enhancer factor 2C
MLEC malectin
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MME membrane metallo-endopeptidase
MXRA7 matrix-remodelling associated 7
NES nestin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NMU neuromedin U
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PIR pirin (iron-binding nuclear protein)
PLK1 polo-like kinase 1
PLXND1 plexin D1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PSCA prostate stem cell antigen
RPS11 ribosomal protein S11
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A1 secretoglobin, family 2A, member 1
SEC14L1 SEC14-like 1 (S. cerevisiae)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SET SET nuclear proto-oncogene
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SNN stannin
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae)
STARD7 StAR-related lipid transfer (START) domain containing 7
TFDP1 transcription factor Dp-1
TMEM97 transmembrane protein 97
TMSB15A thymosin beta 15a
TSPAN13 tetraspanin 13
TUBB tubulin, beta class I
USP22 ubiquitin specific peptidase 22
WSB2 WD repeat and SOCS box containing 2
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon