BRD-K80348542_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

262 genes differentially expressed following the BRD-K80348542_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADM adrenomedullin
AKAP8L A kinase (PRKA) anchor protein 8-like
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ATAD2B ATPase family, AAA domain containing 2B
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BCAM basal cell adhesion molecule (Lutheran blood group)
BCAS3 breast carcinoma amplified sequence 3
BCL3 B-cell CLL/lymphoma 3
BHLHE41 basic helix-loop-helix family, member e41
BIRC3 baculoviral IAP repeat containing 3
BST2 bone marrow stromal cell antigen 2
C10ORF10 chromosome 10 open reading frame 10
C8ORF4 chromosome 8 open reading frame 4
CALML5 calmodulin-like 5
CCL2 chemokine (C-C motif) ligand 2
CCNL1 cyclin L1
CDKN2AIP CDKN2A interacting protein
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CGRRF1 cell growth regulator with ring finger domain 1
CLK4 CDC-like kinase 4
CLU clusterin
CNOT4 CCR4-NOT transcription complex, subunit 4
COG4 component of oligomeric golgi complex 4
COL9A3 collagen, type IX, alpha 3
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CROCCP2 ciliary rootlet coiled-coil, rootletin pseudogene 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DIABLO diablo, IAP-binding mitochondrial protein
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
EFNA1 ephrin-A1
FAM179B family with sequence similarity 179, member B
FNTA farnesyltransferase, CAAX box, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GCH1 GTP cyclohydrolase 1
GEM GTP binding protein overexpressed in skeletal muscle
H2BFS H2B histone family, member S (pseudogene)
H3F3B H3 histone, family 3B (H3.3B)
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H4H histone cluster 1, H4h
HOPX HOP homeobox
HP haptoglobin
ICAM1 intercellular adhesion molecule 1
ICAM2 intercellular adhesion molecule 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IRF1 interferon regulatory factor 1
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCTD5 potassium channel tetramerization domain containing 5
KDM3A lysine (K)-specific demethylase 3A
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KLF10 Kruppel-like factor 10
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRCC1 lysine-rich coiled-coil 1
KYNU kynureninase
LPIN2 lipin 2
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
METTL17 methyltransferase like 17
MOAP1 modulator of apoptosis 1
MX2 MX dynamin-like GTPase 2
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NINJ1 ninjurin 1
NOTCH2NL notch 2 N-terminal like
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PDZK1IP1 PDZK1 interacting protein 1
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PRKRIP1 PRKR interacting protein 1 (IL11 inducible)
PRPF3 pre-mRNA processing factor 3
PSPC1 paraspeckle component 1
PTBP2 polypyrimidine tract binding protein 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
RCOR3 REST corepressor 3
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFTN1 raftlin, lipid raft linker 1
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RNF167 ring finger protein 167
RSRC2 arginine/serine-rich coiled-coil 2
SAMD4A sterile alpha motif domain containing 4A
SCYL3 SCY1-like 3 (S. cerevisiae)
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SMIM7 small integral membrane protein 7
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SRSF7 serine/arginine-rich splicing factor 7
STX1A syntaxin 1A (brain)
SUPT7L suppressor of Ty 7 (S. cerevisiae)-like
SYNGR3 synaptogyrin 3
TBL2 transducin (beta)-like 2
TBX2 T-box 2
TERF2IP telomeric repeat binding factor 2, interacting protein
THUMPD2 THUMP domain containing 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLK2 tousled-like kinase 2
TMPRSS3 transmembrane protease, serine 3
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TSC22D3 TSC22 domain family, member 3
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast)
VCPKMT valosin containing protein lysine (K) methyltransferase
ZCCHC8 zinc finger, CCHC domain containing 8
ZFP36 ZFP36 ring finger protein
ZHX2 zinc fingers and homeoboxes 2
ZMYM2 zinc finger, MYM-type 2
ZNF140 zinc finger protein 140

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ADIRF adipogenesis regulatory factor
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AQP1 aquaporin 1 (Colton blood group)
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
AUTS2 autism susceptibility candidate 2
B3GNT1
BAALC brain and acute leukemia, cytoplasmic
BEX4 brain expressed, X-linked 4
BLCAP bladder cancer associated protein
C6ORF62 chromosome 6 open reading frame 62
CA2 carbonic anhydrase II
CALU calumenin
CAV1 caveolin 1, caveolae protein, 22kDa
CCNA2 cyclin A2
CCNE2 cyclin E2
CCNG1 cyclin G1
CD200 CD200 molecule
CDK1 cyclin-dependent kinase 1
CLCA4 chloride channel accessory 4
COL15A1 collagen, type XV, alpha 1
CRABP2 cellular retinoic acid binding protein 2
CTSZ cathepsin Z
CXADR coxsackie virus and adenovirus receptor
CXCL12 chemokine (C-X-C motif) ligand 12
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DPYSL2 dihydropyrimidinase-like 2
DSP desmoplakin
EBP emopamil binding protein (sterol isomerase)
EID1 EP300 interacting inhibitor of differentiation 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5A eukaryotic translation initiation factor 5A
EMX2 empty spiracles homeobox 2
ENDOD1 endonuclease domain containing 1
ENO1 enolase 1, (alpha)
EYA2 EYA transcriptional coactivator and phosphatase 2
FAM20B family with sequence similarity 20, member B
FGL2 fibrinogen-like 2
FHL1 four and a half LIM domains 1
FKBP1A FK506 binding protein 1A, 12kDa
GDI2 GDP dissociation inhibitor 2
GJA1 gap junction protein, alpha 1, 43kDa
GLUD1 glutamate dehydrogenase 1
GLUD2 glutamate dehydrogenase 2
GLUL glutamate-ammonia ligase
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
HLA-F major histocompatibility complex, class I, F
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HRSP12 heat-responsive protein 12
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IGF1R insulin-like growth factor 1 receptor
IGFBP5 insulin-like growth factor binding protein 5
IGFBP6 insulin-like growth factor binding protein 6
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
IPO7 importin 7
ITGA6 integrin, alpha 6
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
LAPTM4B lysosomal protein transmembrane 4 beta
LIPA lipase A, lysosomal acid, cholesterol esterase
LMO2 LIM domain only 2 (rhombotin-like 1)
MAN1A1 mannosidase, alpha, class 1A, member 1
MAT2A methionine adenosyltransferase II, alpha
MDK midkine (neurite growth-promoting factor 2)
METTL9 methyltransferase like 9
MFAP5 microfibrillar associated protein 5
MME membrane metallo-endopeptidase
MPPED2 metallophosphoesterase domain containing 2
MPZL2 myelin protein zero-like 2
MRPL11 mitochondrial ribosomal protein L11
MSMO1 methylsterol monooxygenase 1
MXRA7 matrix-remodelling associated 7
MYO1D myosin ID
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NMU neuromedin U
NT5DC2 5'-nucleotidase domain containing 2
OLFML3 olfactomedin-like 3
PBK PDZ binding kinase
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PGAM1 phosphoglycerate mutase 1 (brain)
PLA2G12A phospholipase A2, group XIIA
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PRDX4 peroxiredoxin 4
PRSS23 protease, serine, 23
PSAT1 phosphoserine aminotransferase 1
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PTDSS1 phosphatidylserine synthase 1
RAB3B RAB3B, member RAS oncogene family
RALGDS ral guanine nucleotide dissociation stimulator
RCN2 reticulocalbin 2, EF-hand calcium binding domain
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC2 syndecan 2
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SEPP1 selenoprotein P, plasma, 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SNN stannin
SPON1 spondin 1, extracellular matrix protein
STIP1 stress-induced phosphoprotein 1
STMN1 stathmin 1
TCF4 transcription factor 4
TFDP1 transcription factor Dp-1
TGFBR3 transforming growth factor, beta receptor III
TMEM230 transmembrane protein 230
TMEM30B transmembrane protein 30B
TMSB15A thymosin beta 15a
TPD52L1 tumor protein D52-like 1
TSPAN13 tetraspanin 13
TUBB tubulin, beta class I
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WSB2 WD repeat and SOCS box containing 2
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon