BRD-K80786583_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

155 genes differentially expressed following the BRD-K80786583_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
AREG amphiregulin
ARG2 arginase 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX2 armadillo repeat containing, X-linked 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BEX4 brain expressed, X-linked 4
BHLHE40 basic helix-loop-helix family, member e40
BIK BCL2-interacting killer (apoptosis-inducing)
BMP2 bone morphogenetic protein 2
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CA2 carbonic anhydrase II
CAPG capping protein (actin filament), gelsolin-like
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CCNL1 cyclin L1
CD24 CD24 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHIC2 cysteine-rich hydrophobic domain 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CTH cystathionine gamma-lyase
DDIT3 DNA-damage-inducible transcript 3
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF1 eukaryotic translation initiation factor 1
EIF4A1 eukaryotic translation initiation factor 4A1
EZR ezrin
FAM107A family with sequence similarity 107, member A
FGFR2 fibroblast growth factor receptor 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL2 FOS-like antigen 2
GADD45B growth arrest and DNA-damage-inducible, beta
GPNMB glycoprotein (transmembrane) nmb
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST2H2BE histone cluster 2, H2be
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGFBP5 insulin-like growth factor binding protein 5
IL1R1 interleukin 1 receptor, type I
IL6 interleukin 6
INSIG1 insulin induced gene 1
IRF1 interferon regulatory factor 1
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KDM6A lysine (K)-specific demethylase 6A
KDM6B lysine (K)-specific demethylase 6B
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
LEFTY1 left-right determination factor 1
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MT1E metallothionein 1E
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
PER2 period circadian clock 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
RGS16 regulator of G-protein signaling 16
RPL10 ribosomal protein L10
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SIK1 salt-inducible kinase 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC38A2 solute carrier family 38, member 2
SOD2 superoxide dismutase 2, mitochondrial
SRRM2 serine/arginine repetitive matrix 2
STC2 stanniocalcin 2
STX1A syntaxin 1A (brain)
TBX3 T-box 3
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGIF1 TGFB-induced factor homeobox 1
THBD thrombomodulin
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM2 transmembrane protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TOB1 transducer of ERBB2, 1
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
VEGFA vascular endothelial growth factor A
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
ZC3H12A zinc finger CCCH-type containing 12A
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
AK1 adenylate kinase 1
AKAP7 A kinase (PRKA) anchor protein 7
ALOX5 arachidonate 5-lipoxygenase
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
BIN1 bridging integrator 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAPN2 calpain 2, (m/II) large subunit
CBX3 chromobox homolog 3
CCNA2 cyclin A2
CD59 CD59 molecule, complement regulatory protein
CD99 CD99 molecule
CPVL carboxypeptidase, vitellogenic-like
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DPYSL2 dihydropyrimidinase-like 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
GOLM1 golgi membrane protein 1
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HOPX HOP homeobox
HOXC6 homeobox C6
HSDL2 hydroxysteroid dehydrogenase like 2
KDM5D lysine (K)-specific demethylase 5D
KIF20A kinesin family member 20A
LAPTM4B lysosomal protein transmembrane 4 beta
LMO2 LIM domain only 2 (rhombotin-like 1)
LPGAT1 lysophosphatidylglycerol acyltransferase 1
LYPLA1 lysophospholipase I
MXRA7 matrix-remodelling associated 7
PODXL podocalyxin-like
PON2 paraoxonase 2
PPAP2C phosphatidic acid phosphatase type 2C
PRSS23 protease, serine, 23
PSIP1 PC4 and SFRS1 interacting protein 1
PSPH phosphoserine phosphatase
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
RTN1 reticulon 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STOM stomatin
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TRIM14 tripartite motif containing 14
TSPAN4 tetraspanin 4
TYMS thymidylate synthetase
WWTR1 WW domain containing transcription regulator 1
Funding