BRD-K80970344_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

107 genes differentially expressed following the BRD-K80970344_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ASNS asparagine synthetase (glutamine-hydrolyzing)
AZU1 azurocidin 1
CAST calpastatin
CD99 CD99 molecule
CLC Charcot-Leyden crystal galectin
CLEC2B C-type lectin domain family 2, member B
CLIC5 chloride intracellular channel 5
COL11A1 collagen, type XI, alpha 1
COL5A1 collagen, type V, alpha 1
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
ELANE elastase, neutrophil expressed
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GCLM glutamate-cysteine ligase, modifier subunit
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GPX2 glutathione peroxidase 2
H2BFS H2B histone family, member S (pseudogene)
HBB hemoglobin, beta
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
KDM3A lysine (K)-specific demethylase 3A
KLF4 Kruppel-like factor 4 (gut)
LCN2 lipocalin 2
LOXL2 lysyl oxidase-like 2
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP7 matrix metallopeptidase 7
NDRG1 N-myc downstream regulated 1
NEB nebulin
NQO1 NAD(P)H dehydrogenase, quinone 1
PIR pirin (iron-binding nuclear protein)
PLAU plasminogen activator, urokinase
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRTN3 proteinase 3
PTPRO protein tyrosine phosphatase, receptor type, O
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERTAD2 SERTA domain containing 2
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRGN serglycin
TGFBI transforming growth factor, beta-induced, 68kDa
TRIM16 tripartite motif containing 16
TXNRD1 thioredoxin reductase 1
UPP1 uridine phosphorylase 1
WNT5A wingless-type MMTV integration site family, member 5A

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
AREG amphiregulin
ATF5 activating transcription factor 5
B3GNT1
CA12 carbonic anhydrase XII
CAPG capping protein (actin filament), gelsolin-like
CTSC cathepsin C
FDX1 ferredoxin 1
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GATA3 GATA binding protein 3
GRB14 growth factor receptor-bound protein 14
IGFBP4 insulin-like growth factor binding protein 4
IGFBP5 insulin-like growth factor binding protein 5
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KRT14 keratin 14, type I
LAGE3 L antigen family, member 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MARCKSL1 MARCKS-like 1
MET MET proto-oncogene, receptor tyrosine kinase
MGP matrix Gla protein
MREG melanoregulin
NFIB nuclear factor I/B
NR2F1 nuclear receptor subfamily 2, group F, member 1
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFA platelet-derived growth factor alpha polypeptide
PIP prolactin-induced protein
PLAGL1 pleiomorphic adenoma gene-like 1
POSTN periostin, osteoblast specific factor
PRDX2 peroxiredoxin 2
PRPF4 pre-mRNA processing factor 4
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
SELT selenoprotein T
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPT9 septin 9
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPDEF SAM pointed domain containing ETS transcription factor
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
TFRC transferrin receptor
TNC tenascin C
Funding