BRD-K81418486_vorinostat_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

107 genes differentially expressed following the BRD-K81418486_vorinostat_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADD3 adducin 3 (gamma)
AKAP12 A kinase (PRKA) anchor protein 12
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARMCX3 armadillo repeat containing, X-linked 3
BAMBI BMP and activin membrane-bound inhibitor
C8ORF4 chromosome 8 open reading frame 4
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CDC42 cell division cycle 42
CTSV cathepsin V
DUSP6 dual specificity phosphatase 6
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EZR ezrin
F13A1 coagulation factor XIII, A1 polypeptide
FKSG49 FKSG49
FOXO4 forkhead box O4
FRMD4B FERM domain containing 4B
FXYD2 FXYD domain containing ion transport regulator 2
GCA grancalcin, EF-hand calcium binding protein
GPC3 glypican 3
GULP1 GULP, engulfment adaptor PTB domain containing 1
H1F0 H1 histone family, member 0
HMG20B high mobility group 20B
ICAM1 intercellular adhesion molecule 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
ISOC1 isochorismatase domain containing 1
JUNB jun B proto-oncogene
LIPA lipase A, lysosomal acid, cholesterol esterase
LRP10 low density lipoprotein receptor-related protein 10
LTB lymphotoxin beta (TNF superfamily, member 3)
LYPD1 LY6/PLAUR domain containing 1
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MEGF9 multiple EGF-like-domains 9
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MTSS1 metastasis suppressor 1
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
OAT ornithine aminotransferase
OPHN1 oligophrenin 1
PERP PERP, TP53 apoptosis effector
RBP1 retinol binding protein 1, cellular
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RPL27A ribosomal protein L27a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SGCE sarcoglycan, epsilon
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SNAP23 synaptosomal-associated protein, 23kDa
SOX9 SRY (sex determining region Y)-box 9
SPP1 secreted phosphoprotein 1
STOM stomatin
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TUBB2B tubulin, beta 2B class IIb
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WBP5 WW domain binding protein 5
WSB1 WD repeat and SOCS box containing 1

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
ATMIN ATM interactor
C1QBP complement component 1, q subcomponent binding protein
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNB2 cyclin B2
CD38 CD38 molecule
CDC25A cell division cycle 25A
CXCL12 chemokine (C-X-C motif) ligand 12
DLK1 delta-like 1 homolog (Drosophila)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
FOXM1 forkhead box M1
FXYD3 FXYD domain containing ion transport regulator 3
GREB1 growth regulation by estrogen in breast cancer 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IRAK1 interleukin-1 receptor-associated kinase 1
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
MAOA monoamine oxidase A
MSMB microseminoprotein, beta-
PLAGL1 pleiomorphic adenoma gene-like 1
PRC1 protein regulator of cytokinesis 1
PUF60 poly-U binding splicing factor 60KDa
PXMP2 peroxisomal membrane protein 2, 22kDa
S100A8 S100 calcium binding protein A8
SCUBE2 signal peptide, CUB domain, EGF-like 2
SELENBP1 selenium binding protein 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SNX7 sorting nexin 7
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TARP TCR gamma alternate reading frame protein
TLE4 transducin-like enhancer of split 4
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
VCAM1 vascular cell adhesion molecule 1
VCAN versican
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