BRD-K81814927_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

258 genes differentially expressed following the BRD-K81814927_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADAM9 ADAM metallopeptidase domain 9
ADD3 adducin 3 (gamma)
AEBP1 AE binding protein 1
AQP1 aquaporin 1 (Colton blood group)
ARL4C ADP-ribosylation factor-like 4C
ASPN asporin
C3ORF14 chromosome 3 open reading frame 14
CADM1 cell adhesion molecule 1
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CD163 CD163 molecule
CD47 CD47 molecule
CD93 CD93 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH13 cadherin 13
CFB complement factor B
CFH complement factor H
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLDN3 claudin 3
CLEC2B C-type lectin domain family 2, member B
CLEC5A C-type lectin domain family 5, member A
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DIAPH2 diaphanous-related formin 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYD dihydropyrimidine dehydrogenase
DPYSL3 dihydropyrimidinase-like 3
EGFL6 EGF-like-domain, multiple 6
EGLN3 egl-9 family hypoxia-inducible factor 3
EID1 EP300 interacting inhibitor of differentiation 1
EMP1 epithelial membrane protein 1
ESRP1 epithelial splicing regulatory protein 1
FABP6 fatty acid binding protein 6, ileal
FCN3 ficolin (collagen/fibrinogen domain containing) 3
FLT1 fms-related tyrosine kinase 1
FOLR1 folate receptor 1 (adult)
FSD1 fibronectin type III and SPRY domain containing 1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
HAPLN1 hyaluronan and proteoglycan link protein 1
HIST1H2BD histone cluster 1, H2bd
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HP haptoglobin
HRSP12 heat-responsive protein 12
IGFBP5 insulin-like growth factor binding protein 5
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITM2C integral membrane protein 2C
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNK3 potassium channel, two pore domain subfamily K, member 3
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KDR kinase insert domain receptor
KIAA0226L KIAA0226-like
KIAA1462 KIAA1462
LDB2 LIM domain binding 2
LDOC1 leucine zipper, down-regulated in cancer 1
LRRC17 leucine rich repeat containing 17
LY96 lymphocyte antigen 96
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MAOA monoamine oxidase A
MEF2C myocyte enhancer factor 2C
MME membrane metallo-endopeptidase
MYOF myoferlin
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEBL nebulette
NPTX2 neuronal pentraxin II
P3H2 prolyl 3-hydroxylase 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PECAM1 platelet/endothelial cell adhesion molecule 1
PLVAP plasmalemma vesicle associated protein
PRUNE2 prune homolog 2 (Drosophila)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGCC regulator of cell cycle
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SCGB1D2 secretoglobin, family 1D, member 2
SCN3A sodium channel, voltage gated, type III alpha subunit
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFTPB surfactant protein B
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SNX10 sorting nexin 10
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
ST14 suppression of tumorigenicity 14 (colon carcinoma)
ST18 suppression of tumorigenicity 18, zinc finger
STC1 stanniocalcin 1
STK38L serine/threonine kinase 38 like
SULF1 sulfatase 1
TCF4 transcription factor 4
TEK TEK tyrosine kinase, endothelial
THBS2 thrombospondin 2
TMSB15A thymosin beta 15a
TP53TG1 TP53 target 1 (non-protein coding)
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TSPAN12 tetraspanin 12
VCAN versican
VSIG4 V-set and immunoglobulin domain containing 4
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ACBD3 acyl-CoA binding domain containing 3
ADGRG2 adhesion G protein-coupled receptor G2
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AQP3 aquaporin 3 (Gill blood group)
ARID4B AT rich interactive domain 4B (RBP1-like)
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1
ARPC5L actin related protein 2/3 complex, subunit 5-like
AURKA aurora kinase A
BASP1 brain abundant, membrane attached signal protein 1
BRD1 bromodomain containing 1
BRD3 bromodomain containing 3
BRPF1 bromodomain and PHD finger containing, 1
BST2 bone marrow stromal cell antigen 2
CCNA2 cyclin A2
CCNF cyclin F
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2AIP CDKN2A interacting protein
CDR2 cerebellar degeneration-related protein 2, 62kDa
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHERP calcium homeostasis endoplasmic reticulum protein
CRY1 cryptochrome circadian clock 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
ELF1 E74-like factor 1 (ets domain transcription factor)
FAM208B family with sequence similarity 208, member B
FAM46A family with sequence similarity 46, member A
FAM53C family with sequence similarity 53, member C
FASTKD5 FAST kinase domains 5
FNBP4 formin binding protein 4
FOSL1 FOS-like antigen 1
FOXO3 forkhead box O3
FSCN1 fascin actin-bundling protein 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GAS1 growth arrest-specific 1
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GGNBP2 gametogenetin binding protein 2
GOLGA8A golgin A8 family, member A
GPATCH8 G patch domain containing 8
GTPBP4 GTP binding protein 4
HEXIM1 hexamethylene bis-acetamide inducible 1
HNRNPL heterogeneous nuclear ribonucleoprotein L
HOMER1 homer scaffolding protein 1
HSF2 heat shock transcription factor 2
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IFRD2 interferon-related developmental regulator 2
IGFBP4 insulin-like growth factor binding protein 4
IGKV1-5 immunoglobulin kappa variable 1-5
INPP1 inositol polyphosphate-1-phosphatase
IRS2 insulin receptor substrate 2
JMJD6 jumonji domain containing 6
KRT10 keratin 10, type I
KRT14 keratin 14, type I
KRT17 keratin 17, type I
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAPK6 mitogen-activated protein kinase 6
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MCL1 myeloid cell leukemia 1
MYBPC1 myosin binding protein C, slow type
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCK1 NCK adaptor protein 1
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
PARP2 poly (ADP-ribose) polymerase 2
PCM1 pericentriolar material 1
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
PPIF peptidylprolyl isomerase F
PRKCA protein kinase C, alpha
PRPF4 pre-mRNA processing factor 4
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTX3 pentraxin 3, long
RANBP2 RAN binding protein 2
RBM15 RNA binding motif protein 15
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RHOF ras homolog family member F (in filopodia)
RNMT RNA (guanine-7-) methyltransferase
RPP38 ribonuclease P/MRP 38kDa subunit
S100P S100 calcium binding protein P
SACS sacsin molecular chaperone
SCAF8 SR-related CTD-associated factor 8
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SF1 splicing factor 1
SFN stratifin
SLC22A3 solute carrier family 22 (organic cation transporter), member 3
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMOX spermine oxidase
SOX4 SRY (sex determining region Y)-box 4
SPRY2 sprouty homolog 2 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRSF11 serine/arginine-rich splicing factor 11
STIL SCL/TAL1 interrupting locus
STOM stomatin
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNJ2 synaptojanin 2
TBC1D4 TBC1 domain family, member 4
TBP TATA box binding protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TCP1 t-complex 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TMEM11 transmembrane protein 11
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOB1 transducer of ERBB2, 1
TOB2 transducer of ERBB2, 2
TRAF4 TNF receptor-associated factor 4
TRIM29 tripartite motif containing 29
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
TSPYL5 TSPY-like 5
TXLNA taxilin alpha
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
USP1 ubiquitin specific peptidase 1
WDR82 WD repeat domain 82
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
WTAP Wilms tumor 1 associated protein
XBP1 X-box binding protein 1
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2
ZBTB11 zinc finger and BTB domain containing 11
ZCCHC2 zinc finger, CCHC domain containing 2
Funding