BRD-K82024442_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

79 genes differentially expressed following the BRD-K82024442_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ALCAM activated leukocyte cell adhesion molecule
APMAP adipocyte plasma membrane associated protein
AREG amphiregulin
CASP2 caspase 2, apoptosis-related cysteine peptidase
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CTSO cathepsin O
CYB5A cytochrome b5 type A (microsomal)
CYFIP2 cytoplasmic FMR1 interacting protein 2
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DLK1 delta-like 1 homolog (Drosophila)
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EZR ezrin
GLDC glycine dehydrogenase (decarboxylating)
LDHB lactate dehydrogenase B
MAL mal, T-cell differentiation protein
MAP1A microtubule-associated protein 1A
MBP myelin basic protein
NTS neurotensin
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
RBP4 retinol binding protein 4, plasma
SCGB1D2 secretoglobin, family 1D, member 2
SRGN serglycin
TDO2 tryptophan 2,3-dioxygenase
TXNIP thioredoxin interacting protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)

decreased expression

Symbol Name
ASPN asporin
ATG3 autophagy related 3
CA2 carbonic anhydrase II
CCDC86 coiled-coil domain containing 86
CCNF cyclin F
CD58 CD58 molecule
CST3 cystatin C
CXCL14 chemokine (C-X-C motif) ligand 14
DCK deoxycytidine kinase
DEGS1 delta(4)-desaturase, sphingolipid 1
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
DOCK4 dedicator of cytokinesis 4
DPYSL2 dihydropyrimidinase-like 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5 eukaryotic translation initiation factor 5
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM57A family with sequence similarity 57, member A
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FXYD3 FXYD domain containing ion transport regulator 3
GATA3 GATA binding protein 3
HES1 hes family bHLH transcription factor 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1 hematological and neurological expressed 1
HSPB8 heat shock 22kDa protein 8
IGHM immunoglobulin heavy constant mu
KCTD12 potassium channel tetramerization domain containing 12
LMO2 LIM domain only 2 (rhombotin-like 1)
MAPK6 mitogen-activated protein kinase 6
MKNK2 MAP kinase interacting serine/threonine kinase 2
PDLIM3 PDZ and LIM domain 3
PLBD1 phospholipase B domain containing 1
PLK2 polo-like kinase 2
PLN phospholamban
PMP22 peripheral myelin protein 22
REG1A regenerating islet-derived 1 alpha
REG3A regenerating islet-derived 3 alpha
RFC2 replication factor C (activator 1) 2, 40kDa
SAMD4A sterile alpha motif domain containing 4A
SDC1 syndecan 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
SVIL supervillin
TACC2 transforming, acidic coiled-coil containing protein 2
TM4SF1 transmembrane 4 L six family member 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TUBB6 tubulin, beta 6 class V
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
YBX3 Y box binding protein 3
Funding