BRD-K82580504_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

120 genes differentially expressed following the BRD-K82580504_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AHNAK AHNAK nucleoprotein
APOLD1 apolipoprotein L domain containing 1
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
ATF3 activating transcription factor 3
BEX4 brain expressed, X-linked 4
BTG2 BTG family, member 2
CADM1 cell adhesion molecule 1
CD24 CD24 molecule
CD9 CD9 molecule
CDC42 cell division cycle 42
CHIC2 cysteine-rich hydrophobic domain 2
CLIC4 chloride intracellular channel 4
CREB5 cAMP responsive element binding protein 5
CXADR coxsackie virus and adenovirus receptor
CYR61 cysteine-rich, angiogenic inducer, 61
EGR1 early growth response 1
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FGFR1 fibroblast growth factor receptor 1
FGFR3 fibroblast growth factor receptor 3
FHL2 four and a half LIM domains 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXC1 forkhead box C1
GAB2 GRB2-associated binding protein 2
GAS6 growth arrest-specific 6
GPR183 G protein-coupled receptor 183
HBEGF heparin-binding EGF-like growth factor
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IGF1R insulin-like growth factor 1 receptor
IL6 interleukin 6
INHBA inhibin, beta A
IRF6 interferon regulatory factor 6
KLF6 Kruppel-like factor 6
KLF7 Kruppel-like factor 7 (ubiquitous)
KLHL21 kelch-like family member 21
KLK5 kallikrein-related peptidase 5
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MCL1 myeloid cell leukemia 1
MPZL2 myelin protein zero-like 2
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1M metallothionein 1M
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAV2 neuron navigator 2
NEBL nebulette
NFIL3 nuclear factor, interleukin 3 regulated
NR4A1 nuclear receptor subfamily 4, group A, member 1
NXN nucleoredoxin
PDLIM4 PDZ and LIM domain 4
RAP1GAP2 RAP1 GTPase activating protein 2
RGCC regulator of cell cycle
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP1 secreted frizzled-related protein 1
SLIT2 slit homolog 2 (Drosophila)
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
STX3 syntaxin 3
SULF1 sulfatase 1
TACSTD2 tumor-associated calcium signal transducer 2
TGFBR3 transforming growth factor, beta receptor III
THBD thrombomodulin
THBS1 thrombospondin 1
TJP2 tight junction protein 2
TRIB1 tribbles pseudokinase 1
TUSC3 tumor suppressor candidate 3
XPO7 exportin 7
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
AMIGO2 adhesion molecule with Ig-like domain 2
ARGLU1 arginine and glutamate rich 1
AURKA aurora kinase A
BASP1 brain abundant, membrane attached signal protein 1
C1S complement component 1, s subcomponent
C2CD2 C2 calcium-dependent domain containing 2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDCA4 cell division cycle associated 4
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CXCL5 chemokine (C-X-C motif) ligand 5
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EED embryonic ectoderm development
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GOLGA8A golgin A8 family, member A
HLTF helicase-like transcription factor
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA8 heat shock 70kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGLV2-23 immunoglobulin lambda variable 2-23
IRS2 insulin receptor substrate 2
KANK2 KN motif and ankyrin repeat domains 2
KIAA0907 KIAA0907
MMP9 matrix metallopeptidase 9
PCDH9 protocadherin 9
PDGFC platelet derived growth factor C
PNISR PNN-interacting serine/arginine-rich protein
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RSRP1 arginine/serine-rich protein 1
TARDBP TAR DNA binding protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TRAK2 trafficking protein, kinesin binding 2
TRIM2 tripartite motif containing 2
TSPAN13 tetraspanin 13
Funding