BRD-K82732294_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

140 genes differentially expressed following the BRD-K82732294_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
BAG3 BCL2-associated athanogene 3
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFB complement factor B
CFD complement factor D (adipsin)
CHEK2 checkpoint kinase 2
CISH cytokine inducible SH2-containing protein
CLDN3 claudin 3
CLDN7 claudin 7
CTSL cathepsin L
CXCL8 chemokine (C-X-C motif) ligand 8
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
EML3 echinoderm microtubule associated protein like 3
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GSE1 Gse1 coiled-coil protein
HCAR3 hydroxycarboxylic acid receptor 3
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ICAM1 intercellular adhesion molecule 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL1R1 interleukin 1 receptor, type I
IL6 interleukin 6
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KRT19 keratin 19, type I
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MLPH melanophilin
MME membrane metallo-endopeptidase
MMP1 matrix metallopeptidase 1
MMP12 matrix metallopeptidase 12
MMP3 matrix metallopeptidase 3
MPZL1 myelin protein zero-like 1
MT1M metallothionein 1M
MYC v-myc avian myelocytomatosis viral oncogene homolog
NID2 nidogen 2 (osteonidogen)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDGFRL platelet-derived growth factor receptor-like
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAU plasminogen activator, urokinase
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RGS4 regulator of G-protein signaling 4
S100A9 S100 calcium binding protein A9
SAT1 spermidine/spermine N1-acetyltransferase 1
SELENBP1 selenium binding protein 1
SFN stratifin
SFRP4 secreted frizzled-related protein 4
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SST somatostatin
STC1 stanniocalcin 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM176B transmembrane protein 176B
TXNRD1 thioredoxin reductase 1
TYMP thymidine phosphorylase
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein
ZNF274 zinc finger protein 274

decreased expression

Symbol Name
ACP6 acid phosphatase 6, lysophosphatidic
ADARB1 adenosine deaminase, RNA-specific, B1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
BAD BCL2-associated agonist of cell death
BEX1 brain expressed, X-linked 1
BMI1 BMI1 proto-oncogene, polycomb ring finger
C2CD5 C2 calcium-dependent domain containing 5
CA12 carbonic anhydrase XII
CALD1 caldesmon 1
CCND1 cyclin D1
CCNF cyclin F
CDC25B cell division cycle 25B
COG2 component of oligomeric golgi complex 2
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK3 dickkopf WNT signaling pathway inhibitor 3
ENOPH1 enolase-phosphatase 1
FABP7 fatty acid binding protein 7, brain
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FXYD2 FXYD domain containing ion transport regulator 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GPM6A glycoprotein M6A
HOPX HOP homeobox
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IPW imprinted in Prader-Willi syndrome (non-protein coding)
ITGAV integrin, alpha V
KIF20A kinesin family member 20A
KRT17 keratin 17, type I
KRT7 keratin 7, type II
LMNA lamin A/C
LUC7L3 LUC7-like 3 (S. cerevisiae)
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MARCKS myristoylated alanine-rich protein kinase C substrate
MGLL monoglyceride lipase
MTSS1 metastasis suppressor 1
NFIB nuclear factor I/B
PDGFC platelet derived growth factor C
PEG10 paternally expressed 10
PLCB4 phospholipase C, beta 4
PLK1 polo-like kinase 1
PNMA2 paraneoplastic Ma antigen 2
PODXL podocalyxin-like
PTHLH parathyroid hormone-like hormone
RBM34 RNA binding motif protein 34
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SMAD3 SMAD family member 3
SNX7 sorting nexin 7
SOBP sine oculis binding protein homolog (Drosophila)
SORBS3 sorbin and SH3 domain containing 3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SQLE squalene epoxidase
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TOB1 transducer of ERBB2, 1
TRIM9 tripartite motif containing 9
UBE3C ubiquitin protein ligase E3C
UPK1B uroplakin 1B
ZIC1 Zic family member 1