BRD-K83336168_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

137 genes differentially expressed following the BRD-K83336168_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
AGR2 anterior gradient 2
ASS1 argininosuccinate synthase 1
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CDKN2A cyclin-dependent kinase inhibitor 2A
CHMP4A charged multivesicular body protein 4A
CKB creatine kinase, brain
CLIC4 chloride intracellular channel 4
COCH cochlin
COTL1 coactosin-like F-actin binding protein 1
CST6 cystatin E/M
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EZR ezrin
FOS FBJ murine osteosarcoma viral oncogene homolog
FZD7 frizzled class receptor 7
GADD45B growth arrest and DNA-damage-inducible, beta
GADD45G growth arrest and DNA-damage-inducible, gamma
GAL galanin/GMAP prepropeptide
GSE1 Gse1 coiled-coil protein
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
KLF4 Kruppel-like factor 4 (gut)
LTF lactotransferrin
MAP7 microtubule-associated protein 7
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MYB v-myb avian myeloblastosis viral oncogene homolog
NPR3 natriuretic peptide receptor 3
PDLIM1 PDZ and LIM domain 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
RASA4 RAS p21 protein activator 4
REEP1 receptor accessory protein 1
RPL31 ribosomal protein L31
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFN stratifin
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SORD sorbitol dehydrogenase
SPON1 spondin 1, extracellular matrix protein
TFF3 trefoil factor 3 (intestinal)
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TGFBI transforming growth factor, beta-induced, 68kDa
TIMP3 TIMP metallopeptidase inhibitor 3
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TXNL4B thioredoxin-like 4B
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
ZNHIT1 zinc finger, HIT-type containing 1

decreased expression

Symbol Name
ACVR1 activin A receptor, type I
ADGRG6 adhesion G protein-coupled receptor G6
ADIPOR2 adiponectin receptor 2
AHR aryl hydrocarbon receptor
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
ARG2 arginase 2
ARHGAP32 Rho GTPase activating protein 32
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BCL6 B-cell CLL/lymphoma 6
CCL20 chemokine (C-C motif) ligand 20
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CPE carboxypeptidase E
CTNND1 catenin (cadherin-associated protein), delta 1
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL14 chemokine (C-X-C motif) ligand 14
DLC1 DLC1 Rho GTPase activating protein
DUSP6 dual specificity phosphatase 6
EIF5A eukaryotic translation initiation factor 5A
EPAS1 endothelial PAS domain protein 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F3 coagulation factor III (thromboplastin, tissue factor)
FABP4 fatty acid binding protein 4, adipocyte
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR2 fibroblast growth factor receptor 2
FOXO3 forkhead box O3
FZD6 frizzled class receptor 6
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GLIPR1 GLI pathogenesis-related 1
GNLY granulysin
GPC3 glypican 3
GPNMB glycoprotein (transmembrane) nmb
HOPX HOP homeobox
HSPA13 heat shock protein 70kDa family, member 13
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
KAT6A K(lysine) acetyltransferase 6A
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
LMO2 LIM domain only 2 (rhombotin-like 1)
LPAR6 lysophosphatidic acid receptor 6
LYZ lysozyme
MATN2 matrilin 2
MKL2 MKL/myocardin-like 2
MME membrane metallo-endopeptidase
MT1E metallothionein 1E
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH10 myosin, heavy chain 10, non-muscle
NCOA3 nuclear receptor coactivator 3
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRIP1 nuclear receptor interacting protein 1
OSBPL8 oxysterol binding protein-like 8
PEG10 paternally expressed 10
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PLLP plasmolipin
PRKCH protein kinase C, eta
PRKCI protein kinase C, iota
PRNP prion protein
PTPRE protein tyrosine phosphatase, receptor type, E
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RGS5 regulator of G-protein signaling 5
S100P S100 calcium binding protein P
SDC4 syndecan 4
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPRED2 sprouty-related, EVH1 domain containing 2
STX3 syntaxin 3
TF transferrin
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFRC transferrin receptor
TGFBR3 transforming growth factor, beta receptor III
TRIB1 tribbles pseudokinase 1
TRIM2 tripartite motif containing 2
Funding