BRD-K83794624_P8624_NPC_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

267 genes differentially expressed following the BRD-K83794624_P8624_NPC_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMDEC1 ADAM-like, decysin 1
AIM1 absent in melanoma 1
ANPEP alanyl (membrane) aminopeptidase
ANXA4 annexin A4
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
AZU1 azurocidin 1
BLNK B-cell linker
CA12 carbonic anhydrase XII
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPN2 calpain 2, (m/II) large subunit
CCND2 cyclin D2
CD44 CD44 molecule (Indian blood group)
CD52 CD52 molecule
CD9 CD9 molecule
CFD complement factor D (adipsin)
CLC Charcot-Leyden crystal galectin
CLEC2B C-type lectin domain family 2, member B
CLU clusterin
COL15A1 collagen, type XV, alpha 1
CRISP3 cysteine-rich secretory protein 3
CTSV cathepsin V
DACH1 dachshund family transcription factor 1
DPP4 dipeptidyl-peptidase 4
EFHD1 EF-hand domain family, member D1
EIF4A1 eukaryotic translation initiation factor 4A1
F11R F11 receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
FDX1 ferredoxin 1
GAGE3 G antigen 3
GATA3 GATA binding protein 3
GBP2 guanylate binding protein 2, interferon-inducible
GEM GTP binding protein overexpressed in skeletal muscle
GNLY granulysin
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPB8 heat shock 22kDa protein 8
IGHM immunoglobulin heavy constant mu
IL10RA interleukin 10 receptor, alpha
IL13RA1 interleukin 13 receptor, alpha 1
ITGB7 integrin, beta 7
KLF4 Kruppel-like factor 4 (gut)
KLF9 Kruppel-like factor 9
KLRB1 killer cell lectin-like receptor subfamily B, member 1
KRT18 keratin 18, type I
KRT19 keratin 19, type I
LGALS3 lectin, galactoside-binding, soluble, 3
LINC00341 long intergenic non-protein coding RNA 341
LOC100505650 uncharacterized LOC100505650
LRRC17 leucine rich repeat containing 17
MAST3 microtubule associated serine/threonine kinase 3
MIR22HG MIR22 host gene
MMP9 matrix metallopeptidase 9
MOSPD1 motile sperm domain containing 1
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
MYOF myoferlin
NDRG1 N-myc downstream regulated 1
NRGN neurogranin (protein kinase C substrate, RC3)
PCBP2 poly(rC) binding protein 2
PDZK1IP1 PDZK1 interacting protein 1
PEG3 paternally expressed 3
PERP PERP, TP53 apoptosis effector
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNP purine nucleoside phosphorylase
PPAP2A phosphatidic acid phosphatase type 2A
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBP4 retinol binding protein 4, plasma
REG1A regenerating islet-derived 1 alpha
RGCC regulator of cell cycle
RHOBTB3 Rho-related BTB domain containing 3
S100A10 S100 calcium binding protein A10
S100P S100 calcium binding protein P
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SH3YL1 SH3 and SYLF domain containing 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
STC1 stanniocalcin 1
TFPI2 tissue factor pathway inhibitor 2
TPBG trophoblast glycoprotein
TRBC1 T cell receptor beta constant 1
TWF1 twinfilin actin binding protein 1
TXNIP thioredoxin interacting protein
USP10 ubiquitin specific peptidase 10
VNN1 vanin 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WARS tryptophanyl-tRNA synthetase
ZNF331 zinc finger protein 331
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ACACA acetyl-CoA carboxylase alpha
ACOT7 acyl-CoA thioesterase 7
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALCAM activated leukocyte cell adhesion molecule
ANXA3 annexin A3
APOD apolipoprotein D
ARMCX6 armadillo repeat containing, X-linked 6
ASCC3 activating signal cointegrator 1 complex subunit 3
ASCL1 achaete-scute family bHLH transcription factor 1
ATPIF1 ATPase inhibitory factor 1
B3GNT1
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BCL6 B-cell CLL/lymphoma 6
BEX1 brain expressed, X-linked 1
BIRC5 baculoviral IAP repeat containing 5
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BUB3 BUB3 mitotic checkpoint protein
C14ORF1 chromosome 14 open reading frame 1
C2CD5 C2 calcium-dependent domain containing 5
CALCA calcitonin-related polypeptide alpha
CBX5 chromobox homolog 5
CCNA2 cyclin A2
CD164 CD164 molecule, sialomucin
CD81 CD81 molecule
CDC42 cell division cycle 42
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK4 cyclin-dependent kinase 4
CHGB chromogranin B
CLTC clathrin, heavy chain (Hc)
CNOT7 CCR4-NOT transcription complex, subunit 7
CSRP1 cysteine and glycine-rich protein 1
CTBP1 C-terminal binding protein 1
CXCL12 chemokine (C-X-C motif) ligand 12
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLD dihydrolipoamide dehydrogenase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DUSP4 dual specificity phosphatase 4
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
EBP emopamil binding protein (sterol isomerase)
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELAVL1 ELAV like RNA binding protein 1
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EPHA3 EPH receptor A3
ERH enhancer of rudimentary homolog (Drosophila)
ETNK1 ethanolamine kinase 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAM134C family with sequence similarity 134, member C
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGG fibrinogen gamma chain
FKBP3 FK506 binding protein 3, 25kDa
FLOT2 flotillin 2
FSTL1 follistatin-like 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GAS1 growth arrest-specific 1
GLOD4 glyoxalase domain containing 4
GOLPH3 golgi phosphoprotein 3 (coat-protein)
GPX1 glutathione peroxidase 1
GSTP1 glutathione S-transferase pi 1
H2AFV H2A histone family, member V
HN1 hematological and neurological expressed 1
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HNRNPR heterogeneous nuclear ribonucleoprotein R
ICMT isoprenylcysteine carboxyl methyltransferase
IDI1 isopentenyl-diphosphate delta isomerase 1
IFITM2 interferon induced transmembrane protein 2
IGLL1 immunoglobulin lambda-like polypeptide 1
ILF3 interleukin enhancer binding factor 3, 90kDa
KPNB1 karyopherin (importin) beta 1
KRT7 keratin 7, type II
LAT2 linker for activation of T cells family, member 2
LBR lamin B receptor
LDLR low density lipoprotein receptor
LEPR leptin receptor
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LYRM4 LYR motif containing 4
MAGED1 melanoma antigen family D1
MAGED2 melanoma antigen family D2
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAPT microtubule-associated protein tau
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MCUR1 mitochondrial calcium uniporter regulator 1
MED24 mediator complex subunit 24
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MRPL12 mitochondrial ribosomal protein L12
MSL1 male-specific lethal 1 homolog (Drosophila)
MSMO1 methylsterol monooxygenase 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NDN necdin, melanoma antigen (MAGE) family member
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa
NDUFC1 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
NFIL3 nuclear factor, interleukin 3 regulated
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NME1 NME/NM23 nucleoside diphosphate kinase 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NNMT nicotinamide N-methyltransferase
NREP neuronal regeneration related protein
NUP62 nucleoporin 62kDa
NUTF2 nuclear transport factor 2
NXN nucleoredoxin
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PARP1 poly (ADP-ribose) polymerase 1
PCGF2 polycomb group ring finger 2
PCM1 pericentriolar material 1
PCNA proliferating cell nuclear antigen
PEBP1 phosphatidylethanolamine binding protein 1
PGAM1 phosphoglycerate mutase 1 (brain)
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PRMT1 protein arginine methyltransferase 1
PRSS23 protease, serine, 23
PSD3 pleckstrin and Sec7 domain containing 3
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PTOV1 prostate tumor overexpressed 1
PUF60 poly-U binding splicing factor 60KDa
PXMP2 peroxisomal membrane protein 2, 22kDa
QDPR quinoid dihydropteridine reductase
RBBP4 retinoblastoma binding protein 4
RPA1 replication protein A1, 70kDa
RPS11 ribosomal protein S11
SACS sacsin molecular chaperone
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEPT11 septin 11
SET SET nuclear proto-oncogene
SLIRP SRA stem-loop interacting RNA binding protein
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SNRPF small nuclear ribonucleoprotein polypeptide F
SORBS3 sorbin and SH3 domain containing 3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPOP speckle-type POZ protein
SREBF1 sterol regulatory element binding transcription factor 1
SRSF3 serine/arginine-rich splicing factor 3
SRSF9 serine/arginine-rich splicing factor 9
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLE4 transducin-like enhancer of split 4
TMEM2 transmembrane protein 2
TMEM97 transmembrane protein 97
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOP2A topoisomerase (DNA) II alpha 170kDa
TPI1 triosephosphate isomerase 1
TRA2B transformer 2 beta homolog (Drosophila)
TRIM28 tripartite motif containing 28
TUBB tubulin, beta class I
TUBB2B tubulin, beta 2B class IIb
TXLNA taxilin alpha
TYMS thymidylate synthetase
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X
USP22 ubiquitin specific peptidase 22
VCAM1 vascular cell adhesion molecule 1
WDR6 WD repeat domain 6
WDR61 WD repeat domain 61
WSB1 WD repeat and SOCS box containing 1
XPO1 exportin 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZMYM2 zinc finger, MYM-type 2
ZNF22 zinc finger protein 22
Funding