BRD-K83963101_MLN-8054_A375_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

90 genes differentially expressed following the BRD-K83963101_MLN-8054_A375_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACBD3 acyl-CoA binding domain containing 3
ADRB2 adrenoceptor beta 2, surface
ATF3 activating transcription factor 3
BAX BCL2-associated X protein
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
DDB2 damage-specific DNA binding protein 2, 48kDa
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EZR ezrin
FADS1 fatty acid desaturase 1
FAS Fas cell surface death receptor
FDXR ferredoxin reductase
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
GPRC5A G protein-coupled receptor, class C, group 5, member A
H2BFS H2B histone family, member S (pseudogene)
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
IER5 immediate early response 5
KIF20A kinesin family member 20A
LIMCH1 LIM and calponin homology domains 1
MID1 midline 1
PURA purine-rich element binding protein A
RPS27L ribosomal protein S27-like
SESN1 sestrin 1
TFF1 trefoil factor 1
TMEM87A transmembrane protein 87A
TPD52 tumor protein D52
TRIM22 tripartite motif containing 22
TSC22D2 TSC22 domain family, member 2
ZMAT3 zinc finger, matrin-type 3
ZNF274 zinc finger protein 274

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ANXA1 annexin A1
APOD apolipoprotein D
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
BAD BCL2-associated agonist of cell death
C1R complement component 1, r subcomponent
CD58 CD58 molecule
CD59 CD59 molecule, complement regulatory protein
CSRP1 cysteine and glycine-rich protein 1
CSTA cystatin A (stefin A)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL5 chemokine (C-X-C motif) ligand 5
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCK deoxycytidine kinase
DPT dermatopontin
DPYSL3 dihydropyrimidinase-like 3
DSCC1 DNA replication and sister chromatid cohesion 1
EIF5A eukaryotic translation initiation factor 5A
GAS1 growth arrest-specific 1
GRWD1 glutamate-rich WD repeat containing 1
HAT1 histone acetyltransferase 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IL17RB interleukin 17 receptor B
IQGAP2 IQ motif containing GTPase activating protein 2
ITM2A integral membrane protein 2A
KRT5 keratin 5, type II
LAPTM4B lysosomal protein transmembrane 4 beta
MCM6 minichromosome maintenance complex component 6
MMP7 matrix metallopeptidase 7
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1X metallothionein 1X
NFIB nuclear factor I/B
NR1H2 nuclear receptor subfamily 1, group H, member 2
OPN3 opsin 3
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PTN pleiotrophin
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBP1 retinol binding protein 1, cellular
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SFRP4 secreted frizzled-related protein 4
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SORBS1 sorbin and SH3 domain containing 1
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SRPX sushi-repeat containing protein, X-linked
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
THBS2 thrombospondin 2
TPM2 tropomyosin 2 (beta)
TUBB2A tubulin, beta 2A class IIa
Funding